Occurrence and Health Effects of Hexabromocyclododecane: An Updated Review

Brominated flame retardants effect in MCF-7 cells: Impact on vitamin D pathway

(2022) Sara Sousa et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Apoptotic p53 Gene Expression in the Regulation of Persistent Organic Pollutant (POP)-Induced Oxidative Stress in the Intertidal Crab Macrophthalmusjaponicus

(2022) Kiyun Park et al.   Antioxidants

Bioaccumulation and Biomagnification of Hexabromocyclododecane in Marine Biota from China: A Review

(2022) Ying Zhang et al.   Toxics

Hexabromocyclododecanes Are Dehalogenated by CYP168A1 from Pseudomonas aeruginosa Strain HS9

(2021) Ling Huang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Health toxicity effects of brominated flame retardants: From environmental to human exposure

(2021) Joana Feiteiro et al.   ENVIRONMENTAL POLLUTION

Role of Persistent Organic Pollutants in Breast Cancer Progression and Identification of Estrogen Receptor Alpha Inhibitors Using In-Silico Mining and Drug-Drug Interaction Network Approaches

(2021) Bibi Zainab et al.   Biology-Basel

Impact of brominated flame retardants on lipid metabolism: An in vitro approach

(2021) Maria Luz Maia et al.   ENVIRONMENTAL POLLUTION

Assessing the cytotoxic effect of hexabromocyclododecane (HBCD) on liver tissue cultures from fathead minnow (Pimephales promelas)

(2020) J.I. Bertucci et al.   AQUATIC TOXICOLOGY

Hexabromocyclododecanes promoted autophagy through the PI3K/Akt/mTOR pathway in L02 cells

(2019) Yingying Jin et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

Multi-generational effects and variations of stress response by hexabromocyclododecane (HBCD) exposure in the nematode Caenorhabditis elegans

(2019) Haibo Chen et al.   JOURNAL OF ENVIRONMENTAL MANAGEMENT

Diastereoisomer-specific neurotoxicity of hexabromocyclododecane in human SH-SY5Y neuroblastoma cells

(2019) Xiaoli Shi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The enrichment and purification of hexabromocyclododecanes and its effects on thyroid in zebrafish

(2019) Zhen Guo et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Exposure to HBCD promotes adipogenesis both in vitro and in vivo by interfering with Wnt6 expression

(2019) Xinni Xie et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Tetrabromobisphenol A and hexabromocyclododecane isomers in breast milk from the general population in Beijing, China: Contamination levels, temporal trends, nursing infant’s daily intake, and risk assessment

(2019) Morong Huang et al.   CHEMOSPHERE

Flame retardants, hexabromocyclododecane (HCBD) and tetrabromobisphenol a (TBBPA), alter secretion of tumor necrosis factor alpha (TNFα) from human immune cells

(2018) Sharia Yasmin et al.   ARCHIVES OF TOXICOLOGY

Bioconcentration and effects of hexabromocyclododecane exposure in crucian carp (Carassius auratus)

(2018) Huike Dong et al.   ECOTOXICOLOGY

In vitro effects of brominated flame retardants, selected metals and their mixtures on ethoxyresorufin-O-deethylase activity in Mossambica tilapia liver

(2018) Biyan Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

An overview of hexabromocyclododecane (HBCDs) in environmental media with focus on their potential risk and management in China

(2018) Xianghui Cao et al.   ENVIRONMENTAL POLLUTION

Antioxidant gene expression and metabolic responses of earthworms ( Eisenia fetida ) after exposure to various concentrations of hexabromocyclododecane

(2018) Yajuan Shi et al.   ENVIRONMENTAL POLLUTION

Responses of antioxidant and biotransformation enzymes in Carassius carassius exposed to hexabromocyclododecane

(2018) Huike Dong et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Low dose exposure to HBCD, CB-153 or TCDD induces histopathological and hormonal effects and changes in brain protein and gene expression in juvenile female BALB/c mice

(2018) J.D. Rasinger et al.   REPRODUCTIVE TOXICOLOGY

Effects of low-levels of three hexabromocyclododecane diastereomers on the metabolic profiles of pak choi leaves using high-throughput untargeted metabolomics approach

(2018) Yanwei Zhang et al.   ENVIRONMENTAL POLLUTION

Enantioselectivity in Biotransformation and Bioaccumulation Processes of Typical Chiral Contaminants

(2018) Chenye Xu et al.   ENVIRONMENTAL POLLUTION

Hepatic transcriptional dose-response analysis of male and female Fischer rats exposed to hexabromocyclododecane

(2018) Reza Farmahin et al.   FOOD AND CHEMICAL TOXICOLOGY

Roles of maize cytochrome P450 (CYP) enzymes in stereo-selective metabolism of hexabromocyclododecanes (HBCDs) as evidenced by in vitro degradation, biological response and in silico studies

(2018) Honglin Huang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Dietary exposure to brominated flame retardants and risk of type 2 diabetes in the French E3N cohort

(2018) Jeanne Sandrine Ongono et al.   ENVIRONMENT INTERNATIONAL

The “adaptive responses” of low concentrations of HBCD in L02 cells and the underlying molecular mechanisms

(2016) Jing An et al.   CHEMOSPHERE

In vitro study on the biotransformation and cytotoxicity of three hexabromocyclododecane diastereoisomers in liver cells

(2016) Xiaomei Huang et al.   CHEMOSPHERE

Hexabromocyclododecanes (HBCDDs) in surface soils from coastal cities in North China: Correlation between diastereoisomer profiles and industrial activities

(2016) Yueqing Zhang et al.   CHEMOSPHERE

Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture

(2016) David T. Szabo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Stereoselective Metabolism of α-, β-, and γ-Hexabromocyclododecanes (HBCDs) by Human Liver Microsomes and CYP3A4

(2016) Claudio Erratico et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Experimental and Theoretical Evidence for Diastereomer- and Enantiomer-Specific Accumulation and Biotransformation of HBCD in Maize Roots

(2016) Honglin Huang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

NMR- and LC–MS/MS-based urine metabolomic investigation of the subacute effects of hexabromocyclododecane in mice

(2016) Dezhen Wang et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice

(2016) Annette Bernhard et al.   FOOD AND CHEMICAL TOXICOLOGY

Accumulation and phytotoxicity of technical hexabromocyclododecane in maize

(2016) Tong Wu et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Hexabromocyclododecane exposure induces cardiac hypertrophy and arrhythmia by inhibiting miR-1 expression via up-regulation of the homeobox gene Nkx2.5

(2016) Meifang Wu et al.   JOURNAL OF HAZARDOUS MATERIALS

Indoor pollutant hexabromocyclododecane enhances house dust mite-induced activation of human monocyte-derived dendritic cells

(2016) Derya Canbaz et al.   Journal of Immunotoxicology

Advances in enantioselective analysis of chiral brominated flame retardants. Current status, limitations and future perspectives

(2016) Silviu-Laurentiu Badea et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Influence of hexabromocyclododecane and 4-nonylphenol on the regulation of cell growth, apoptosis and migration in prostatic cancer cells

(2016) Seung-Hee Kim et al.   TOXICOLOGY IN VITRO

Brominated flame retardants, hexabromocyclododecane and tetrabromobisphenol A, affect proinflammatory protein expression in human bronchial epithelial cells via disruption of intracellular signaling

(2016) Eiko Koike et al.   TOXICOLOGY IN VITRO

Assessing in-vitro estrogenic effects of currently-used flame retardants

(2016) Boris V. Krivoshiev et al.   TOXICOLOGY IN VITRO

Hexabromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyroid female rats

(2016) I. Miller et al.   TOXICOLOGY LETTERS

Gender specific differences in the liver proteome of rats exposed to short term and low-concentration hexabromocyclododecane (HBCD)

(2016) I. Miller et al.   Toxicology Research

Hexabromocyclododecane and tetrabromobisphenol A alter secretion of interferon gamma (IFN-γ) from human immune cells

(2015) Haifa Almughamsi et al.   ARCHIVES OF TOXICOLOGY

Diastereoisomer-specific effects of hexabromocyclododecanes on hepatic aryl hydrocarbon receptors and cytochrome P450s in zebrafish (Danio rerio)

(2015) Miaomiao Du et al.   CHEMOSPHERE

Hexabromocyclododecane affects benthic-pelagic coupling in an experimental ecosystem

(2015) Clare Bradshaw et al.   ENVIRONMENTAL POLLUTION

Review of hexabromocyclododecane (HBCD) with a focus on legislation and recent publications concerning toxicokinetics and -dynamics

(2015) Christoph Koch et al.   ENVIRONMENTAL POLLUTION

Comparative Metabolism Studies of Hexabromocyclododecane (HBCD) Diastereomers in Male Rats Following a Single Oral Dose

(2015) Heldur Hakk   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Tetrabromobisphenol A and hexabromocyclododecane alter secretion of IL-1βfrom human immune cells

(2015) Sharif Anisuzzaman et al.   Journal of Immunotoxicology

Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDD

(2015) Kelly R. Genskow et al.   NEUROTOXICOLOGY AND TERATOLOGY

HBCDD-induced sustained reduction in mitochondrial membrane potential, ATP and steroidogenesis in peripubertal rat Leydig cells

(2015) Svetlana Fa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Steroid hormone related effects of marine persistent organic pollutants in human H295R adrenocortical carcinoma cells

(2015) Myrthe W. van den Dungen et al.   TOXICOLOGY IN VITRO

Flame retardant associations between children’s handwipes and house dust

(2014) Heather M. Stapleton et al.   CHEMOSPHERE

Levels and trends of PBDEs and HBCDs in the global environment: Status at the end of 2012

(2014) Robin J. Law et al.   ENVIRONMENT INTERNATIONAL

Comparative antioxidant status in freshwater fish Carassius auratus exposed to six current-use brominated flame retardants: A combined experimental and theoretical study

(2013) Mingbao Feng et al.   AQUATIC TOXICOLOGY

Hexabromocyclododecanes in limnic and marine organisms and terrestrial plants from Tianjin, China: Diastereomer- and enantiomer-specific profiles, biomagnification, and human exposure

(2013) Yanwei Zhang et al.   CHEMOSPHERE

Hexabromocyclododecanes in surface sediments and a sediment core from Rivers and Harbor in the northern Chinese city of Tianjin

(2012) Yanwei Zhang et al.   CHEMOSPHERE

Emerging and historical brominated flame retardants in peregrine falcon ( Falco peregrinus ) eggs from Canada and Spain

(2012) Paula Guerra et al.   ENVIRONMENT INTERNATIONAL

Levels, isomer profiles and chiral signatures of particle-bound hexabromocyclododecanes in ambient air around Shanghai, China

(2012) Huiru Li et al.   ENVIRONMENTAL POLLUTION

Diastereoisomer- and Enantiomer-Specific Accumulation, Depuration, and Bioisomerization of Hexabromocyclododecanes in Zebrafish (Danio rerio)

(2012) Miaomiao Du et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Hexabromocyclododecane in consumer fish from South China: Implications for human exposure via dietary intake

(2012) Xiang-Zhou Meng et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Diastereomer-Specific Uptake, Translocation, and Toxicity of Hexabromocyclododecane Diastereoisomers to Maize

(2012) Tong Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tri-decabrominated diphenyl ethers and hexabromocyclododecane in indoor air and dust from Stockholm microenvironments 2: Indoor sources and human exposure

(2011) Cynthia A. de Wit et al.   ENVIRONMENT INTERNATIONAL

Hexabromocyclododecane: Current Understanding of Chemistry, Environmental Fate and Toxicology and Implications for Global Management

(2011) Christopher H. Marvin et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Do Temporal and Geographical Patterns of HBCD and PBDE Flame Retardants in U.S. Fish Reflect Evolving Industrial Usage?

(2011) Da Chen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Simultaneous determination of hexabromocyclododecane, tetrabromobisphenol A, and related compounds in sewage sludge and sediment samples from Ebro River basin (Spain)

(2010) Paula Guerra et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Hexabromocyclododecane determination in seafood samples collected from Japanese coastal areas

(2010) R. Nakagawa et al.   CHEMOSPHERE

Decabromodiphenylether and hexabromocyclododecane in wild birds from the United Kingdom, Sweden and The Netherlands: Screening and time trends

(2010) Heather A. Leslie et al.   CHEMOSPHERE

Hexabromocyclododecanes (HBCDs) in marine fishes along the Chinese coastline

(2010) Chonghuan Xia et al.   CHEMOSPHERE

Fate of tetrabromobisphenol A and hexabromocyclododecane brominated flame retardants in soil and uptake by plants

(2010) Yaning Li et al.   CHEMOSPHERE

Dust from U.K. Primary School Classrooms and Daycare Centers: The Significance of Dust As a Pathway of Exposure of Young U.K. Children to Brominated Flame Retardants and Polychlorinated Biphenyls

(2010) Stuart Harrad et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Biotransformation of HBCD in Biological Systems Can Confound Temporal-Trend Studies

(2010) Gregg T. Tomy et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Exposure to Hexabromocyclododecanes (HBCDs) via Dust Ingestion, but Not Diet, Correlates with Concentrations in Human Serum: Preliminary Results

(2009) Laurence Roosens et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Hexabromocyclododecane in Human Breast Milk: Levels and Enantiomeric Patterns

(2009) Ethel Eljarrat et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Current-Use Brominated Flame Retardants in Water, Sediment, and Fish from English Lakes

(2009) Stuart Harrad et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Dietary Exposure Assessment of Chinese Adults and Nursing Infants to Tetrabromobisphenol-A and Hexabromocyclododecanes: Occurrence Measurements in Foods and Human Milk

(2009) Zhi-Xiong Shi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Brominated flame retardants in the Arctic environment — trends and new candidates

(2009) Cynthia A. de Wit et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Enantiomer-specific accumulation of hexabromocyclododecanes in eggs of predatory birds

(2008) K. Janák et al.   CHEMOSPHERE

Serum Concentrations of Neutral and Phenolic Organohalogens in Pregnant Women and Some of Their Infants in The Netherlands

(2008) Lisethe Meijer et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Hexabromocyclododecanes and Tetrabromobisphenol-A in Indoor Air and Dust in Birmingham, UK: Implications for Human Exposure

(2008) Mohamed Abou-Elwafa Abdallah et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

BROMINATED AND CHLORINATED FLAME RETARDANTS IN LAKE ONTARIO, CANADA, LAKE TROUT (SALVELINUS NAMAYCUSH) BETWEEN 1979 AND 2004 AND POSSIBLE INFLUENCES OF FOOD-WEB CHANGES

(2008) Nargis Ismail et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Determination of brominated flame retardants in food by LC–MS/MS: diastereoisomer-specific hexabromocyclododecane and tetrabromobisphenol A

(2008) Malcolm Driffield et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Enantiomeric specific determination of hexabromocyclododecane by liquid chromatography–quadrupole linear ion trap mass spectrometry in sediment samples

(2008) Paula Guerra et al.   JOURNAL OF CHROMATOGRAPHY A

Dietary exposure to brominated flame retardants correlates with male blood levels in a selected group of Norwegians with a wide range of seafood consumption

(2008) Helle K. Knutsen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Temporal trends of polybrominated diphenyl ethers and hexabromocyclododecane in milk from Stockholm mothers, 1980–2004

(2008) Britta Fängström et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Exposure assessment of fetus and newborn to brominated flame retardants in France: preliminary data

(2008) Jean-Philippe Antignac et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats

(2008) Leo T.M. van der Ven et al.   TOXICOLOGY LETTERS

Concentrations and specific loads of brominated flame retardants in sewage sludge

(2007) Thomas Kupper et al.   CHEMOSPHERE