Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 161, Issue -, Pages 350-355Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2018.05.084
Keywords
In vitro; Toxic effect; Brominated flame retardants (BFRs); Metals; Mixtures; EROD activity
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Funding
- Scientific Research Foundation of Third Institute of Oceanography, State Oceanic Administration, China [2016044]
- Grand Research Foundation of Fujian Province, China [2014Y0044]
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The in vitro effects of individual brominated flame retardants (BFRs), selected metals, and their binary mixtures on ethoxyresorufin-O-deethylase (EROD) activity were evaluated using a plate-reader method. The BFRs, 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), decabromodiphenyl oxide (BDE-209), hexabromocyclododecane (HBCD), and tetrabromobisphenol A (TBBPA), were tested at doses ranging from 0.1 ng/L to 100 mu g/L. Selected metals (Cu2+, Cd2+, Hg2+, and Zn2+) were screened at doses of 0.1 mg/L to 50 mg/L. The activity of EROD was significantly induced by TBBPA, BDE-209, and Zn2+, while HBCD, Cu2+, Cd2+, and Hg2+ decreased EROD activity. Moreover, following exposure to binary mixtures of metals and BFRs, the EROD activity dose-response curves were similar to those of the metals alone, indicating that EROD activity was governed by the metals.
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