FXYD2 antisense oligonucleotide provides an efficient approach for long-lasting relief of chronic peripheral pain

Targeting T-type/CaV3.2 channels for chronic pain

(2021) Song Cai et al.   Translational Research

Long-lasting analgesia via targeted in situ repression of NaV1.7 in mice

(2021) Ana M. Moreno et al.   Science Translational Medicine

The Challenges and Strategies of Antisense Oligonucleotide Drug Delivery

(2021) Maria Gagliardi et al.   Biomedicines

Phosphorothioate modified oligonucleotide–protein interactions

(2020) Stanley T Crooke et al.   NUCLEIC ACIDS RESEARCH

Antisense Drugs Make Sense for Neurological Diseases

(2020) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects

(2020) Jérôme Busserolles et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

(2020) William Renthal et al.   NEURON

Bioconjugated oligonucleotides: recent developments and therapeutic applications

(2019) sebastien benizri et al.   BIOCONJUGATE CHEMISTRY

Therapeutic Antisense Oligonucleotides Are Coming of Age

(2019) C. Frank Bennett   Annual Review of Medicine

Metabolism and Disposition of Volanesorsen, a 2′ MOE Antisense Oligonucleotide, Across Species

(2019) Noah Post et al.   DRUG METABOLISM AND DISPOSITION

Antisense oligonucleotides selectively suppress target RNA in nociceptive neurons of the pain system and can ameliorate mechanical pain

(2018) Apoorva Mohan et al.   PAIN

OUP accepted manuscript

(2018)   PAIN MEDICINE

Selective neuronal silencing using synthetic botulinum molecules alleviates chronic pain in mice

(2018) Maria Maiarù et al.   Science Translational Medicine

Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice

(2018) Cyril Rivat et al.   Nature Communications

Chronic pain as a symptom or a disease

(2018) Rolf-Detlef Treede et al.   PAIN

Advances in Achieving Opioid Analgesia Without Side Effects

(2018) Halina Machelska et al.   Frontiers in Pharmacology

Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer

(2017) Sara Karaki et al.   JOURNAL OF CONTROLLED RELEASE

Oligonucleotide therapies for disorders of the nervous system

(2017) Olga Khorkova et al.   NATURE BIOTECHNOLOGY

Breaking barriers to novel analgesic drug development

(2017) Ajay S. Yekkirala et al.   NATURE REVIEWS DRUG DISCOVERY

Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

(2017) Richard S. Finkel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

(2016) Edward C Emery et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Genetic causes of hypomagnesemia, a clinical overview

(2016) Daan H. H. M Viering et al.   PEDIATRIC NEPHROLOGY

Systematic study of the dynamics and half-lives of newly synthesized proteins in human cells

(2016) Weixuan Chen et al.   Chemical Science

Fxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain

(2016) Stéphanie Ventéo et al.   Scientific Reports

Antisense oligonucleotides in therapy for neurodegenerative disorders

(2015) Melvin M. Evers et al.   ADVANCED DRUG DELIVERY REVIEWS

FXYD2, a γ subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammation

(2015) Feng Wang et al.   CELL RESEARCH

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

(2013) Timothy M Miller et al.   LANCET NEUROLOGY

Single intrathecal administration of the transcription factor decoy AYX1 prevents acute and chronic pain after incisional, inflammatory, or neuropathic injury

(2013) Julien Mamet et al.   PAIN

Neuropathic pain in the general population: A systematic review of epidemiological studies

(2013) O. van Hecke et al.   PAIN

Lipid oligonucleotide conjugates as responsive nanomaterials for drug delivery

(2013) Oleksandr Pokholenko et al.   Journal of Materials Chemistry B

An Evaluation of the Antinociceptive Effects of Phα1β, a Neurotoxin from the Spider Phoneutria nigriventer, and ω-Conotoxin MVIIA, a Cone Snail Conus magus Toxin, in Rat Model of Inflammatory and Neuropathic Pain

(2012) Alessandra Hubner de Souza et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Regulation of the Na,K-ATPase Gamma-Subunit FXYD2 by Runx1 and Ret Signaling in Normal and Injured Non-Peptidergic Nociceptive Sensory Neurons

(2012) Stéphanie Ventéo et al.   PLoS One

A population-based survey of chronic pain and its treatment with prescription drugs

(2011) Robin L. Toblin et al.   PAIN

Pain market

(2010) Irena Melnikova   NATURE REVIEWS DRUG DISCOVERY

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain

(2009) Roger Chou et al.   JOURNAL OF PAIN

Sensitive liposomes encoded with oligonucleotide amphiphiles: a biocompatible switch

(2008) Arnaud Gissot et al.   CHEMICAL COMMUNICATIONS

ASIC3, a sensor of acidic and primary inflammatory pain

(2008) Emmanuel Deval et al.   EMBO JOURNAL