Dampening type 2 properties of group 2 innate lymphoid cells by a gammaherpesvirus infection reprograms alveolar macrophages

Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection

(2022) Fengqi Li et al.   Science Immunology

Ly6C hi monocytes balance regulatory and cytotoxic CD4 T cell responses to control virus-induced immunopathology

(2022) Céline Maquet et al.   Science Immunology

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

(2022) Cedric Bosteels et al.   Cell Reports Medicine

The basic immunology of asthma

(2021) Hamida Hammad et al.   CELL

Role of ILC2 in Viral-Induced Lung Pathogenesis

(2021) Wendy Fonseca et al.   Frontiers in Immunology

Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth

(2021) Julia Gschwend et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation

(2020) Yifei Dong et al.   Frontiers in Immunology

BATF acts as an essential regulator of IL-25–responsive migratory ILC2 cell fate and function

(2020) Mindy M. Miller et al.   Science Immunology

Establishment and Maintenance of the Macrophage Niche

(2020) Martin Guilliams et al.   IMMUNITY

House Dust Mite Induces Bone Marrow IL-33-Responsive ILC2s and TH Cells

(2020) Emma Boberg et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

(2020) Doumet Georges Helou et al.   Nature Communications

In Situ Maturation and Tissue Adaptation of Type 2 Innate Lymphoid Cell Progenitors

(2020) Patrice Zeis et al.   IMMUNITY

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2020) Theo Vos et al.   LANCET

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches

(2019) Madelene W. Dahlgren et al.   IMMUNITY

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation

(2019) Freya R. Svedberg et al.   NATURE IMMUNOLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

(2019) Johnny Bonnardel et al.   IMMUNITY

NicheNet: modeling intercellular communication by linking ligands to target genes

(2019) Robin Browaeys et al.   NATURE METHODS

All along the watchtower: group 2 innate lymphoid cells in allergic responses

(2018) Madelene W Dahlgren et al.   CURRENT OPINION IN IMMUNOLOGY

The hygiene hypothesis: immunological mechanisms of airway tolerance

(2018) Eline Haspeslagh et al.   CURRENT OPINION IN IMMUNOLOGY

T cells and ILC2s are major effector cells in influenza-induced exacerbation of allergic airway inflammation in mice

(2018) Bobby W. S. Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Innate Lymphoid Cells: Diversity, Plasticity, and Unique Functions in Immunity

(2018) Marco Colonna   IMMUNITY

Why Innate Lymphoid Cells?

(2018) Maya E. Kotas et al.   IMMUNITY

Epigenome analysis links gene regulatory elements in group 2 innate lymphocytes to asthma susceptibility

(2018) Ralph Stadhouders et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense

(2018) Yuefeng Huang et al.   SCIENCE

Pulmonary neuroendocrine cells amplify allergic asthma responses

(2018) Pengfei Sui et al.   SCIENCE

Group 2 Innate Lymphoid Cells in Pulmonary Immunity and Tissue Homeostasis

(2018) Barbara C. Mindt et al.   Frontiers in Immunology

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Trained Immunity and Local Innate Immune Memory in the Lung

(2018) Mihai G. Netea et al.   CELL

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

(2018) Merav Cohen et al.   CELL

Innate immune crosstalk in asthmatic airways: Innate lymphoid cells coordinate polarization of lung macrophages

(2018) Jihyun Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Role of viral infections in the development and exacerbation of asthma in children

(2017) Tuomas Jartti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PD-1 regulates KLRG1+group 2 innate lymphoid cells

(2017) Samuel Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-γ increases susceptibility to influenza A infection through suppression of group II innate lymphoid cells

(2017) D Califano et al.   Mucosal Immunology

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

(2017) Christoph S. N. Klose et al.   NATURE

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

(2017) Vânia Cardoso et al.   NATURE

Nextflow enables reproducible computational workflows

(2017) Paolo Di Tommaso et al.   NATURE BIOTECHNOLOGY

First-Breath-Induced Type 2 Pathways Shape the Lung Immune Environment

(2017) Simona Saluzzo et al.   Cell Reports

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin

(2016) Matthew T. Stier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s

(2016) Jakob von Moltke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity

(2016) Yoichiro Ohne et al.   NATURE IMMUNOLOGY

IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs

(2016) Suzanne M Bal et al.   NATURE IMMUNOLOGY

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

(2016) Jonathan S Silver et al.   NATURE IMMUNOLOGY

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

BubbleGUM: automatic extraction of phenotype molecular signatures and comprehensive visualization of multiple Gene Set Enrichment Analyses

(2015) Lionel Spinelli et al.   BMC GENOMICS

Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

(2015) Heinrich Schlums et al.   IMMUNITY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

Barrier Epithelial Cells and the Control of Type 2 Immunity

(2015) Hamida Hammad et al.   IMMUNITY

Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33

(2015) Christina A. Christianson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

(2015) Timotheus Y F Halim et al.   NATURE IMMUNOLOGY

Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

(2015) Claudia U Duerr et al.   NATURE IMMUNOLOGY

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

(2015) Kazuyo Moro et al.   NATURE IMMUNOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

(2015) M. J. Schuijs et al.   SCIENCE

circlize implements and enhances circular visualization in R

(2014) Zuguang Gu et al.   BIOINFORMATICS

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

(2014) Christopher J. Oliphant et al.   IMMUNITY

Enhanced innate type 2 immune response in peripheral blood from patients with asthma

(2014) Kathleen R. Bartemes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures

(2014) Matthew J. Gold et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation

(2014) J. Beale et al.   Science Translational Medicine

Recognition Strategies of Group 3 Innate Lymphoid Cells

(2014) Monica Killig et al.   Frontiers in Immunology

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

TH2, allergy and group 2 innate lymphoid cells

(2013) Paula Licona-Limón et al.   NATURE IMMUNOLOGY

A Gammaherpesvirus Uses Alternative Splicing to Regulate Its Tropism and Its Sensitivity to Neutralization

(2013) Bénédicte Machiels et al.   PLoS Pathogens

The Transcription Factor GATA-3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells

(2012) Thomas Hoyler et al.   IMMUNITY

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

New Paradigms in Type 2 Immunity

(2012) B. Pulendran et al.   SCIENCE

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Role of viral respiratory infections in asthma and asthma exacerbations

(2010) William W Busse et al.   LANCET

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Early-life EBV infection protects against persistent IgE sensitization

(2009) Shanie Saghafian-Hedengren et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY