Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF

(2022) Xin Li et al.   Life Science Alliance

Biology of lung macrophages in health and disease

(2022) Helena Aegerter et al.   IMMUNITY

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

(2021) Els Wauters et al.   CELL RESEARCH

Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia

(2021) Rogan A. Grant et al.   NATURE

Does tissue imprinting restrict macrophage plasticity?

(2021) Martin Guilliams et al.   NATURE IMMUNOLOGY

Deciphering the state of immune silence in fatal COVID-19 patients

(2021) Pierre Bost et al.   Nature Communications

Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

(2021) Yu Zhao et al.   Science Immunology

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

(2021) Ryan S Thwaites et al.   Science Immunology

Single-cell multi-omics analysis of the immune response in COVID-19

(2021) Emily Stephenson et al.   NATURE MEDICINE

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COVID-19 disease severity and indicator of the need for mechanical ventilation, ARDS and mortality

(2021) Adeline Lim et al.   Annals of Intensive Care

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

(2021) Lina Ma et al.   Science Immunology

A specific low-density neutrophil population correlates with hypercoagulation and disease severity in hospitalized COVID-19 patients

(2021) Samantha M. Morrissey et al.   JCI Insight

SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19

(2021) Alba Grifoni et al.   Cell Host & Microbe

Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth

(2021) Julia Gschwend et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity

(2021) L. Vanderbeke et al.   Nature Communications

Mavrilimumab in patients with severe COVID-19 pneumonia and systemic hyperinflammation (MASH-COVID): an investigator initiated, multicentre, double-blind, randomised, placebo-controlled trial

(2021) Paul C Cremer et al.   Lancet Rheumatology

Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19

(2021) Daniel E. Leisman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A humanized mouse model of chronic COVID-19

(2021) Esen Sefik et al.   NATURE BIOTECHNOLOGY

Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial

(2021) Benjamin A Fisher et al.   Lancet Respiratory Medicine

Lenzilumab in hospitalised patients with COVID-19 pneumonia (LIVE-AIR): a phase 3, randomised, placebo-controlled trial

(2021) Zelalem Temesgen et al.   Lancet Respiratory Medicine

Dynamics of human monocytes and airway macrophages during healthy aging and after transplant

(2020) Adam J. Byrne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

(2020) Helena Aegerter et al.   NATURE IMMUNOLOGY

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients

(2020) Pierre Bost et al.   CELL

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

Serum KL‐6 concentrations as a novel biomarker of severe COVID19

(2020) Miriana d'Alessandro et al.   JOURNAL OF MEDICAL VIROLOGY

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

(2020) Runhong Zhou et al.   IMMUNITY

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

(2020) Robert Lorenz Chua et al.   NATURE BIOTECHNOLOGY

Sargramostim to treat patients with acute hypoxic respiratory failure due to COVID-19 (SARPAC): A structured summary of a study protocol for a randomised controlled trial

(2020) Cedric Bosteels et al.   Trials

Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities

(2020) Puja Mehta et al.   Lancet Respiratory Medicine

Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

(2020) Daniela Weiskopf et al.   Science Immunology

Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis

(2020) Arpan Sharma Neupane et al.   CELL

Growth Differentiation Factor-15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized with COVID-19

(2020) Peder L. Myhre et al.   CIRCULATION

Tissue-Specific Immunopathology in Fatal COVID-19

(2020) David A. Dorward et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

(2020) Sean X. Gu et al.   Nature Reviews Cardiology

Neutrophil GM‐CSF receptor dynamics in acute lung injury

(2019) Silvia Alessandris et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhaled GM-CSF for Pulmonary Alveolar Proteinosis

(2019) Ryushi Tazawa et al.   NEW ENGLAND JOURNAL OF MEDICINE

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts

(2018) Rosalie M. Sterner et al.   BLOOD

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

(2016) Lianne van de Laar et al.   IMMUNITY

The relative balance of GM-CSF and TGF-β1 regulates lung epithelial barrier function

(2015) Christian E. Overgaard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhaled Granulocyte/Macrophage Colony–Stimulating Factor as Treatment of Pneumonia-associated Acute Respiratory Distress Syndrome

(2014) Susanne Herold et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity

(2014) Kristin Westphalen et al.   NATURE

Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages

(2014) Christoph Schneider et al.   NATURE IMMUNOLOGY

Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes

(2013) Claudia Jakubzick et al.   IMMUNITY

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protecting Against Post-influenza Bacterial Pneumonia by Increasing Phagocyte Recruitment and ROS Production

(2013) R. Subramaniam et al.   JOURNAL OF INFECTIOUS DISEASES

GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells

(2012) Melanie Greter et al.   IMMUNITY

Alveolar epithelial cells orchestrate DC function in murine viral pneumonia

(2012) Barbara Unkel et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

GM-CSF provides autocrine protection for murine alveolar epithelial cells from oxidant-induced mitochondrial injury

(2011) Anne Sturrock et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

GM-CSF in the Lung Protects against Lethal Influenza Infection

(2011) Fang-Fang Huang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Down-regulation of granulocyte-macrophage colony-stimulating factor by 3C-like proteinase in transfected A549 human lung carcinoma cells

(2011) Hsien-Hua Liao et al.   BMC IMMUNOLOGY

A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury*

(2011) Robert Paine et al.   CRITICAL CARE MEDICINE

Mechanisms of suppression of alveolar epithelial cell GM-CSF expression in the setting of hyperoxic stress

(2009) Anne Sturrock et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Familial pulmonary alveolar proteinosis caused by mutations inCSF2RA

(2008) Takuji Suzuki et al.   JOURNAL OF EXPERIMENTAL MEDICINE