Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma

(2014) Hae Yong Yoo et al.   NATURE GENETICS

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

(2014) Mamiko Sakata-Yanagimoto et al.   NATURE GENETICS

Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas

(2014) Teresa Palomero et al.   NATURE GENETICS

Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma

(2013) F. Asmar et al.   HAEMATOLOGICA

ROQUIN/RC3H1 Alterations Are Not Found in Angioimmunoblastic T-Cell Lymphoma

(2013) Tiphanie Auguste et al.   PLoS One

Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice

(2012) J. I. Ellyard et al.   BLOOD

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

(2012) F. Lemonnier et al.   BLOOD

The development and function of follicular helper T cells in immune responses

(2012) Maogen Chen et al.   Cellular & Molecular Immunology

5-Hydroxymethylcytosine – the elusive epigenetic mark in mammalian DNA

(2012) Edita Kriukienė et al.   CHEMICAL SOCIETY REVIEWS

Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation

(2012) M. A. Kroenke et al.   JOURNAL OF IMMUNOLOGY

TET2 is essential for survival and hematopoietic stem cell homeostasis

(2012) K Shide et al.   LEUKEMIA

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

TET2 Mutations Are Associated with Specific 5-Methylcytosine and 5-Hydroxymethylcytosine Profiles in Patients with Chronic Myelomonocytic Leukemia

(2012) Cristina Pérez et al.   PLoS One

Tet2 disruption leads to enhanced self-renewal and altered differentiation of fetal liver hematopoietic stem cells

(2012) Hiroyoshi Kunimoto et al.   Scientific Reports

The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression

(2011) Julia Robertson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

(2011) Z. Li et al.   BLOOD

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

(2011) Cyril Quivoron et al.   CANCER CELL

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

(2011) William A. Pastor et al.   NATURE

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

(2011) Gabriella Ficz et al.   NATURE

Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses

(2011) Emmanuel Eggermann et al.   NATURE REVIEWS NEUROSCIENCE

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

(2011) M. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Follicular helper T cells: implications in neoplastic hematopathology

(2011) Philippe Gaulard et al.   SEMINARS IN DIAGNOSTIC PATHOLOGY

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

DNA methylation prevents CTCF-mediated silencing of the oncogeneBCL6in B cell lymphomas

(2010) Anne Y. Lai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

(2010) Myunggon Ko et al.   NATURE

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Characterization of c-Maf Transcription Factor in Normal and Neoplastic Hematolymphoid Tissue and Its Relevance in Plasma Cell Neoplasia

(2009) Yasodha Natkunam et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

(2009) O. Abdel-Wahab et al.   BLOOD

Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms

(2009) A. M. Jankowska et al.   BLOOD

Advances in the understanding and management of angioimmunoblastic T-cell lymphoma

(2009) Laurence de Leval et al.   BRITISH JOURNAL OF HAEMATOLOGY

Follicular Helper T Cells: Lineage and Location

(2009) Nicolas Fazilleau et al.   IMMUNITY

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-β inhibits c-Maf-induced IL-21 production in CD4+ T cells

(2009) Yukiko Hiramatsu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

(2009) Pierre Fenaux et al.   LANCET ONCOLOGY

Acquired mutations in TET2 are common in myelodysplastic syndromes

(2009) Saskia M C Langemeijer et al.   NATURE GENETICS

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Characterization of Ayu17-449 gene expression and resultant kidney pathology in a knockout mouse model

(2008) Hua Tang et al.   TRANSGENIC RESEARCH

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY