Steatosis and Metabolic Disorders Associated with Synergistic Activation of the CAR/RXR Heterodimer by Pesticides

The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders

(2022) Sheng Zhang et al.   Cell Death & Disease

Diagnosis and management of secondary causes of steatohepatitis

(2021) Roman Liebe et al.   JOURNAL OF HEPATOLOGY

Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures

(2020) Vanessa Delfosse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

(2020) Clémence Rives et al.   Biomolecules

Pregnane X receptor mediates steatotic effects of propiconazole and tebuconazole in human liver cell lines

(2019) Constanze Knebel et al.   ARCHIVES OF TOXICOLOGY

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor

(2018) Céline Lukowicz et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Role of Nuclear Receptors in the Pathophysiology, Natural Course, and Drug Treatment of NAFLD in Humans

(2016) Stefano Ballestri et al.   ADVANCES IN THERAPY

Nuclear receptors and nonalcoholic fatty liver disease 1 1This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie.

(2016) Matthew C. Cave et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Exposure to an environmentally relevant mixture of organochlorine compounds and polychlorinated biphenyls Promotes hepatic steatosis in male Ob/Ob mice

(2016) Charlee Mulligan et al.   ENVIRONMENTAL TOXICOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way

(2016) Alice Marmugi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mancozeb, a fungicide routinely used in agriculture, worsens nonalcoholic fatty liver disease in the human HepG2 cell model

(2016) Anna Virginia Adriana Pirozzi et al.   TOXICOLOGY LETTERS

Targeting xenobiotic receptors PXR and CAR in human diseases

(2015) Monimoy Banerjee et al.   DRUG DISCOVERY TODAY

Small-molecule modulators of the constitutive androstane receptor

(2015) Milu T Cherian et al.   Expert Opinion on Drug Metabolism & Toxicology

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

(2015) Vanessa Delfosse et al.   Nature Communications

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

(2015) Douglas J. Kojetin et al.   Nature Communications

Deciphering the roles of the constitutive androstane receptor in energy metabolism

(2014) Jiong Yan et al.   ACTA PHARMACOLOGICA SINICA

Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents

(2014) Laila Al-Eryani et al.   TOXICOLOGIC PATHOLOGY

Environmental Pollution: A Tangible Risk for NAFLD Pathogenesis

(2013) Mario Arciello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lessons from Mouse Models of High-Fat Diet-Induced NAFLD

(2013) Akinobu Nakamura et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of CAR and PXR in xenobiotic sensing and metabolism

(2012) Yue-Ming Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

Toxicant-associated Steatohepatitis

(2012) Banrida Wahlang et al.   TOXICOLOGIC PATHOLOGY

The retinoid X receptors and their ligands

(2011) Marcia I. Dawson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Non-alcoholic fatty liver disease

(2011) Briohny W. Smith et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Activation of RXR–PPAR heterodimers by organotin environmental endocrine disruptors

(2009) Albane le Maire et al.   EMBO REPORTS

PXR and CAR in energy metabolism

(2009) Taira Wada et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor

(2008) Tsuyoshi Nakanishi   JOURNAL OF TOXICOLOGICAL SCIENCES

Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. A review

(2007) Blanca Antizar-Ladislao   ENVIRONMENT INTERNATIONAL

Xenoreceptors CAR and PXR Activation and Consequences on Lipid Metabolism, Glucose Homeostasis, and Inflammatory Response

(2007) Amélie Moreau et al.   MOLECULAR PHARMACEUTICS