Lessons from Mouse Models of High-Fat Diet-Induced NAFLD

Increasing Incidence of Intrahepatic Cholangiocarcinoma and its Relationship to Chronic Viral Hepatitis

(2017) Kwang-Yu Chang et al.   Journal of the National Comprehensive Cancer Network

Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice

(2013) K. Tajima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment

(2013) Jason R. Clapper et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals

(2013) Howard C. Masuoka et al.   Annals of the New York Academy of Sciences

Statins in Nonalcoholic Fatty Liver Disease and Steatohepatitis: Updated Review

(2013) William Nseir et al.   Current Atherosclerosis Reports

In Vitro and in Vivo Models of Non-Alcoholic Fatty Liver Disease (NAFLD)

(2013) Giridhar Kanuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

(2013) Derrick M. Van Rooyen et al.   JOURNAL OF HEPATOLOGY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr−/− Mice

(2013) Marijana Radonjic et al.   PLoS One

What about non-alcoholic fatty liver disease as a new criterion to define metabolic syndrome?

(2013) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

SnapShot: Insulin Signaling Pathways

(2012) Takashi Kadowaki et al.   CELL

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance

(2012) Robert V. Farese et al.   Cell Metabolism

Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2012) S. E. Inzucchi et al.   DIABETES CARE

By the numbers: New estimates from the IDF Diabetes Atlas Update for 2012

(2012) Leonor Guariguata   DIABETES RESEARCH AND CLINICAL PRACTICE

Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance

(2012) A. Nakamura et al.   DIABETOLOGIA

Diabetes and cancer (1): evaluating the temporal relationship between type 2 diabetes and cancer incidence

(2012) J. A. Johnson et al.   DIABETOLOGIA

Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials

(2012) G. Musso et al.   DIABETOLOGIA

Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?

(2012) Lokpal S. Bhatia et al.   EUROPEAN HEART JOURNAL

The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

(2012) Naga Chalasani et al.   GASTROENTEROLOGY

Metformin for Liver Cancer Prevention in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

(2012) Zhi-Jiang Zhang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma

(2012) William C. Palmer et al.   JOURNAL OF HEPATOLOGY

Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis

(2012) Hiroshi Noto et al.   PLoS One

Large-Scale Long-Term Follow-Up Study of Japanese Patients With Non-Alcoholic Fatty Liver Disease for the Onset of Hepatocellular Carcinoma

(2011) Yusuke Kawamura et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Ablation of PI3K p110-  Prevents High-Fat Diet-Induced Liver Steatosis

(2011) M. Chattopadhyay et al.   DIABETES

Reduced Risk of Colorectal Cancer With Metformin Therapy in Patients With Type 2 Diabetes: A meta-analysis

(2011) Z.-J. Zhang et al.   DIABETES CARE

Association of thiazolidinediones with liver cancer and colorectal cancer in type 2 diabetes mellitus

(2011) Chia-Hsuin Chang et al.   HEPATOLOGY

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and treatment

(2011) Briohny W. Smith et al.   Nature Reviews Endocrinology

Unmasking Differential Effects of Rosiglitazone and Pioglitazone in the Combination Treatment with n-3 Fatty Acids in Mice Fed a High-Fat Diet

(2011) Vladimir Kus et al.   PLoS One

Impact of glucose tolerance on the severity of non-alcoholic steatohepatitis

(2011) Akinobu Nakamura et al.   Journal of Diabetes Investigation

Nonalcoholic Fatty Liver Disease Increases Risk of Death Among Patients With Diabetes: A Community-Based Cohort Study

(2010) Leon A Adams et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Down-Regulation of Adipogenesis and Hyperglycemia in Diet-Induced Obesity Mouse Model by Aloe QDM

(2010) Hyun-Seok Kong et al.   Biomolecules & Therapeutics

Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma

(2010) Manal M. Hassan et al.   CANCER

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

(2010) A. DeCensi et al.   Cancer Prevention Research

Adipose Tissue Dysfunction Signals Progression of Hepatic Steatosis Towards Nonalcoholic Steatohepatitis in C57Bl/6 Mice

(2010) C. Duval et al.   DIABETES

Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials

(2010) J. A. Johnson et al.   DIABETOLOGIA

Insulin, glucose and the increased risk of cancer in patients with type 2 diabetes

(2010) J. A. Johnson et al.   DIABETOLOGIA

Metformin: Taking away the candy for cancer?

(2010) Mathilde Jalving et al.   EUROPEAN JOURNAL OF CANCER

Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years

(2010) V. W.-S. Wong et al.   GUT

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease

(2010) Giovanni Musso et al.   HEPATOLOGY

Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: An open-label, pilot study

(2010) Masato Yoneda et al.   HEPATOLOGY RESEARCH

Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet

(2010) Tomonori Muraoka et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance

(2010) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

High Fat Diet Induced Hepatic Steatosis Establishes a Permissive Microenvironment for Colorectal Metastases and Promotes Primary Dysplasia in a Murine Model

(2009) Michael Nathan VanSaun et al.   AMERICAN JOURNAL OF PATHOLOGY

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

(2009) Karla F. Leavens et al.   Cell Metabolism

Diet-induced hepatocellular carcinoma in genetically predisposed mice

(2009) A. E. Hill-Baskin et al.   HUMAN MOLECULAR GENETICS

A Pilot Study Using Simvastatin in the Treatment of Nonalcoholic Steatohepatitis

(2009) Austin Nelson et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease

(2009) Yuichi Nozaki et al.   JOURNAL OF HEPATOLOGY

The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis

(2009) S. Guo et al.   MOLECULAR AND CELLULAR BIOLOGY

Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese

(2008) Chong Yew Tan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pioglitazone retrieves hepatic antioxidant DNA repair in a mice model of high fat diet

(2008) Pi-Jung Hsiao et al.   BMC MOLECULAR BIOLOGY

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding

(2008) Naoto Kubota et al.   Cell Metabolism

Selective versus Total Insulin Resistance: A Pathogenic Paradox

(2008) Michael S. Brown et al.   Cell Metabolism

Crucial role of insulin receptor substrate-2 in compensatory β-cell hyperplasia in response to high fat diet-induced insulin resistance

(2008) I. Takamoto et al.   DIABETES OBESITY & METABOLISM

Impact of Small-Molecule Glucokinase Activator on Glucose Metabolism and β-Cell Mass

(2008) Akinobu Nakamura et al.   ENDOCRINOLOGY

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

(2008) Mary E. Rinella et al.   JOURNAL OF LIPID RESEARCH

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome

(2008) M.-Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epidemiology of Nonalcoholic Fatty Liver Disease: A Global Perspective

(2008) Mariana Lazo et al.   SEMINARS IN LIVER DISEASE