The Role of Ryanodine Receptors in Regulating Neuronal Activity and Its Connection to the Development of Alzheimer’s Disease

Role of the endoplasmic reticulum in synaptic transmission

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Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory

(2022) Florian Hiess et al.   Communications Biology

The RyR‐calstabin interaction stabilizer S107 protects hippocampal neurons from GABAergic synaptic alterations induced by Abeta42 oligomers

(2022) Enis Hidisoglu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Inhibitory conductance controls place field dynamics in the hippocampus

(2022) Manuel Valero et al.   Cell Reports

The Molecular Basis for the Calcium-Dependent Slow Afterhyperpolarization in CA1 Hippocampal Pyramidal Neurons

(2021) Giriraj Sahu et al.   Frontiers in Physiology

Amyloid β-protein and beyond: the path forward in Alzheimer’s disease

(2020) Dominic M Walsh et al.   CURRENT OPINION IN NEUROBIOLOGY

Amyloid Beta42 oligomers up‐regulate the excitatory synapses by potentiating presynaptic release while impairing postsynaptic NMDA receptors

(2020) Andrea Marcantoni et al.   JOURNAL OF PHYSIOLOGY-LONDON

Amyloid beta 42 oligomers induce neuronal and synaptic receptor dysfunctions

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Limiting RyR2 Open Time Prevents Alzheimer’s Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation

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Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer’s disease amyloidosis

(2019) Jan-Oliver Hollnagel et al.   PLoS One

Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate

(2019) Yang He et al.   Nature Communications

The Ever-Growing Puzzle of Asynchronous Release

(2019) Andrei Rozov et al.   Frontiers in Cellular Neuroscience

Alterations in spontaneous delta and gamma activity might provide clues to detect changes induced by amyloid-β administration

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Excitatory and Inhibitory Neurons Utilize Different Ca 2+ Sensors and Sources to Regulate Spontaneous Release

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Intracellular Ca2+stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer’s disease

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Ryanodine Receptor-Mediated Calcium Release Has a Key Role in Hippocampal LTD Induction

(2018) Alejandra Arias-Cavieres et al.   Frontiers in Cellular Neuroscience

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor

(2017) Renaud Bussiere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of RyRs in the ER Attenuates 6-OHDA-Induced Calcium Overload, Cellular Hypo-Excitability and Apoptosis in Dopaminergic Neurons

(2017) Lu Huang et al.   Frontiers in Cellular Neuroscience

Dantrolene, A Treatment for Alzheimer Disease?

(2015) Li Liang et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons

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Non- -blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure

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The storm before the quiet: neuronal hyperactivity and Aβ in the presymptomatic stages of Alzheimer's disease

(2015) Anita Stargardt et al.   NEUROBIOLOGY OF AGING

Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K+ current inhibition mediated by activation of caspases and GSK-3

(2015) Federico Scala et al.   NEUROBIOLOGY OF AGING

Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics

(2015) Friedrich W. Johenning et al.   PLOS BIOLOGY

The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease

(2014) Jie Liu et al.   Channels

Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+channels and ryanodine receptors

(2014) Danielle Mandikian et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Structure of a mammalian ryanodine receptor

(2014) Ran Zalk et al.   NATURE

Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release

(2013) Pascal S. Kaeser et al.   Annual Review of Physiology

L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner

(2013) Yue Wang et al.   NEUROBIOLOGY OF AGING

Firing properties of entorhinal cortex neurons and early alterations in an Alzheimer's disease transgenic model

(2013) Andrea Marcantoni et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels

(2013) Lucian Medrihan et al.   Nature Communications

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Synchronous and asynchronous modes of synaptic transmission utilize different calcium sources

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Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease

(2012) Olivier Thibault et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Early Presynaptic and Postsynaptic Calcium Signaling Abnormalities Mask Underlying Synaptic Depression in Presymptomatic Alzheimer's Disease Mice

(2012) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Ryanodine Receptor Blockade Reduces Amyloid-  Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

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Independent Vesicle Pools Underlie Different Modes of Release during Neuronal Development

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Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease

(2012) Shreaya Chakroborty et al.   PLoS One

Enhancement of Asynchronous Release from Fast-Spiking Interneuron in Human and Rat Epileptic Neocortex

(2012) Man Jiang et al.   PLOS BIOLOGY

Thalamic Ryanodine Receptors Are Involved in Controlling the Tonic Firing of Thalamocortical Neurons and Inflammatory Pain Signal Processing

(2011) E. Cheong et al.   JOURNAL OF NEUROSCIENCE

Intracellular Ca2+release-dependent inactivation of Ca2+currents in thalamocortical relay neurons

(2010) Vladan Rankovic et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

(2009) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities

(2009) Jin-Tai Yu et al.   PROGRESS IN NEUROBIOLOGY

Amyloid   Oligomers (A 1-42 Globulomer) Suppress Spontaneous Synaptic Activity by Inhibition of P/Q-Type Calcium Currents

(2008) V. Nimmrich et al.   JOURNAL OF NEUROSCIENCE

Dantrolene: Mechanisms of Neuroprotection and Possible Clinical Applications in the Neurointensive Care Unit

(2008) Susanne Muehlschlegel et al.   Neurocritical Care

Control of KCa Channels by Calcium Nano/Microdomains

(2008) Bernd Fakler et al.   NEURON

Nanodomain Coupling between Ca2+ Channels and Ca2+ Sensors Promotes Fast and Efficient Transmitter Release at a Cortical GABAergic Synapse

(2008) Iancu Bucurenciu et al.   NEURON

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE