Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei

An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes

(2022) James Budzak et al.   Nature Communications

Stage-specific transcription activator ESB1 regulates monoallelic antigen expression in Trypanosoma brucei

(2022) Lara López-Escobar et al.   Nature Microbiology

The Trypanosoma brucei subpellicular microtubule array is organized into functionally discrete subdomains defined by microtubule associated proteins

(2021) Amy N. Sinclair et al.   PLoS Pathogens

VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center

(2021) Beatrice Amos et al.   NUCLEIC ACIDS RESEARCH

Evolution and Natural History of Membrane Trafficking in Eukaryotes

(2020) Kira More et al.   CURRENT BIOLOGY

Evolutionary Dynamics of the Spindle Assembly Checkpoint in Eukaryotes

(2020) Geert J.P.L. Kops et al.   CURRENT BIOLOGY

Control of assembly of extra-axonemal structures: the paraflagellar rod of trypanosomes

(2020) Aline A. Alves et al.   JOURNAL OF CELL SCIENCE

Scaling of Subcellular Structures

(2020) Wallace F. Marshall   Annual Review of Cell and Developmental Biology

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

(2020) Manuel Saldivia et al.   Nature Microbiology

A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions

(2020) Konstantin Barylyuk et al.   Cell Host & Microbe

Leishmaniaflagellum attachment zone is critical for flagellar pocket shape, development in the sand fly, and pathogenicity in the host

(2019) Jack D. Sunter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mosaic origin of the eukaryotic kinetochore

(2019) Eelco C. Tromer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coordination of the Cell Cycle in Trypanosomes

(2019) Richard J. Wheeler et al.   Annual Review of Microbiology

The New Tree of Eukaryotes

(2019) Fabien Burki et al.   TRENDS IN ECOLOGY & EVOLUTION

Proteomic Analysis of the Cell Cycle of Procylic FormTrypanosoma brucei

(2018) Thomas W. M. Crozier et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of TOEFAZ1-interacting proteins reveals key regulators of Trypanosoma brucei cytokinesis

(2018) Nicholas A. Hilton et al.   MOLECULAR MICROBIOLOGY

Faithful chromosome segregation in Trypanosoma brucei requires a cohort of divergent spindle-associated proteins with distinct functions

(2018) Qing Zhou et al.   NUCLEIC ACIDS RESEARCH

Molecular model of the mitochondrial genome segregation machinery inTrypanosoma brucei

(2018) Anneliese Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direction of flagellum beat propagation is controlled by proximal/distal outer dynein arm asymmetry

(2018) Beatrice Freya Lucy Edwards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parasite motility is critical for virulence of African trypanosomes

(2018) Michelle M. Shimogawa et al.   Scientific Reports

Degradation of cyclin B is critical for nuclear division in Trypanosoma brucei

(2018) Hanako Hayashi et al.   Biology Open

The CIF1 protein is a master orchestrator of trypanosome cytokinesis that recruits several cytokinesis regulators to the cytokinesis-initiation site

(2018) Qing Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular landmarks of Trypanosoma brucei and Leishmania mexicana

(2018) Clare Halliday et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

OMIM.org: leveraging knowledge across phenotype–gene relationships

(2018) Joanna S Amberger et al.   NUCLEIC ACIDS RESEARCH

The Pfam protein families database in 2019

(2018) Sara El-Gebali et al.   NUCLEIC ACIDS RESEARCH

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The nuclear proteome of Trypanosoma brucei

(2017) Carina Goos et al.   PLoS One

Extensive flagellar remodeling during the complex life cycle ofParatrypanosoma, an early-branching trypanosomatid

(2017) Tomáš Skalický et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein diversity in discrete structures at the distal tip of the trypanosome flagellum

(2017) Vladimir Varga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A subcellular map of the human proteome

(2017) Peter J. Thul et al.   SCIENCE

TrypTag.org: A Trypanosome Genome-wide Protein Localisation Resource

(2017) Samuel Dean et al.   TRENDS IN PARASITOLOGY

Charting organellar importomes by quantitative mass spectrometry

(2017) Christian D. Peikert et al.   Nature Communications

The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes

(2017) Susanne Kramer   PLoS Pathogens

Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism

(2016) Andrew P. Jackson et al.   CURRENT BIOLOGY

High-throughput Gene Tagging in Trypanosoma brucei

(2016) Philip Dyer et al.   Jove-Journal of Visualized Experiments

A dynamic coordination of flagellum and cytoplasmic cytoskeleton assembly specifies cell morphogenesis in trypanosomes

(2015) J. D. Sunter et al.   JOURNAL OF CELL SCIENCE

Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in Trypanosoma brucei

(2015) Michael R. McAllaster et al.   MOLECULAR BIOLOGY OF THE CELL

γ-Tubulin complex inTrypanosoma brucei: molecular composition, subunit interdependence and requirement for axonemal central pair protein assembly

(2015) Qing Zhou et al.   MOLECULAR MICROBIOLOGY

The nucleoporin Mlp2 is involved in chromosomal distribution during mitosis in trypanosomatids

(2015) Christelle Morelle et al.   NUCLEIC ACIDS RESEARCH

A toolkit enabling efficient, scalable and reproducible gene tagging in trypanosomatids

(2015) S. Dean et al.   Open Biology

On the extent and role of the small proteome in the parasitic eukaryote Trypanosoma brucei

(2014) Megan Ericson et al.   BMC BIOLOGY

Discovery of Unconventional Kinetochores in Kinetoplastids

(2014) Bungo Akiyoshi et al.   CELL

Insect Stage-Specific Receptor Adenylate Cyclases Are Localized to Distinct Subdomains of the Trypanosoma brucei Flagellar Membrane

(2014) Edwin A. Saada et al.   EUKARYOTIC CELL

Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology

(2014) Polly Hayes et al.   JOURNAL OF CELL BIOLOGY

High-Confidence Glycosome Proteome for Procyclic Form Trypanosoma brucei by Epitope-Tag Organelle Enrichment and SILAC Proteomics

(2014) Maria Lucia S. Güther et al.   JOURNAL OF PROTEOME RESEARCH

Proteomic Analysis of Intact Flagella of ProcyclicTrypanosoma bruceiCells Identifies Novel Flagellar Proteins with Unique Sub-localization and Dynamics

(2014) Ines Subota et al.   MOLECULAR & CELLULAR PROTEOMICS

Antigenic variation in African trypanosomes

(2014) David Horn   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Evolution of parasitism in kinetoplastid flagellates

(2014) Julius Lukeš et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Motility and more: the flagellum of Trypanosoma brucei

(2014) Gerasimos Langousis et al.   NATURE REVIEWS MICROBIOLOGY

Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity

(2014) Sanaa E. Jehi et al.   NUCLEIC ACIDS RESEARCH

Identification of Paralogous Life-Cycle Stage Specific Cytoskeletal Proteins in the Parasite Trypanosoma brucei

(2014) Neil Portman et al.   PLoS One

Evolutionary cell biology: Two origins, one objective: Fig. 1.

(2014) Michael Lynch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen

(2014) Nathaniel G. Jones et al.   PLoS Pathogens

Proteomic Analysis of the Acidocalcisome, an Organelle Conserved from Bacteria to Human Cells

(2014) Guozhong Huang et al.   PLoS Pathogens

Tracking the Biogenesis and Inheritance of Subpellicular Microtubule inTrypanosoma bruceiwith Inducible YFP-α-Tubulin

(2014) Omar Sheriff et al.   Biomed Research International

Forward motility is essential for trypanosome infection in the tsetse fly

(2013) Brice Rotureau et al.   CELLULAR MICROBIOLOGY

Trypanosoma brucei Tb927.2.6100 Is an Essential Protein Associated with Kinetoplast DNA

(2013) Kirsten Beck et al.   EUKARYOTIC CELL

Cytokinesis inTrypanosoma bruceidiffers between bloodstream and tsetse trypomastigote forms: implications for microtubule-based morphogenesis and mutant analysis

(2013) Richard J. Wheeler et al.   MOLECULAR MICROBIOLOGY

Evolution of microtubule organizing centers across the tree of eukaryotes

(2013) Naoji Yubuki et al.   PLANT JOURNAL

Identification and Characterization of a Stage Specific Membrane Protein Involved in Flagellar Attachment in Trypanosoma brucei

(2013) Katherine Woods et al.   PLoS One

A Minimal Anaphase Promoting Complex/Cyclosome (APC/C) in Trypanosoma brucei

(2013) Mohamed Bessat et al.   PLoS One

Detailed interrogation of trypanosome cell biology via differential organelle staining and automated image analysis

(2012) Richard J Wheeler et al.   BMC BIOLOGY

Dynamic Localization of Trypanosoma brucei Mitochondrial DNA Polymerase ID

(2012) Jeniffer Concepción-Acevedo et al.   EUKARYOTIC CELL

Mitochondrial Outer Membrane Proteome ofTrypanosoma bruceiReveals Novel Factors Required to Maintain Mitochondrial Morphology

(2012) Moritz Niemann et al.   MOLECULAR & CELLULAR PROTEOMICS

A modular and optimized single marker system for generating Trypanosoma brucei cell lines expressing T7 RNA polymerase and the tetracycline repressor

(2012) S. K. Poon et al.   Open Biology

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

(2011) S. Alsford et al.   GENOME RESEARCH

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Reconstructing the evolutionary history of the centriole from protein components

(2010) M. E. Hodges et al.   JOURNAL OF CELL SCIENCE

Localization of gene products using a chromosomally tagged GFP-fusion library in the fission yeastSchizosaccharomyces pombe

(2009) Aki Hayashi et al.   GENES TO CELLS

The paraflagellar rod of kinetoplastid parasites: From structure to components and function

(2009) Neil Portman et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography

(2009) S. Lacomble et al.   JOURNAL OF CELL SCIENCE

Expression and cellular localisation of calpain-like proteins in Trypanosoma brucei

(2009) Wen Liu et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

The Cajal body

(2008) Glenn E. Morris   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2  phosphorylation at Thr169

(2008) S. Kramer et al.   JOURNAL OF CELL SCIENCE

McKusick's Online Mendelian Inheritance in Man (OMIM(R))

(2008) J. Amberger et al.   NUCLEIC ACIDS RESEARCH

The Chromosomal Passenger Complex and a Mitotic Kinesin Interact with the Tousled-Like Kinase in Trypanosomes to Regulate Mitosis and Cytokinesis

(2008) Ziyin Li et al.   PLoS One

A comprehensive analysis of Trypanosoma brucei mitochondrial proteome

(2008) Aswini K. Panigrahi et al.   PROTEOMICS

Asymmetric Cell Division as a Route to Reduction in Cell Length and Change in Cell Morphology in Trypanosomes

(2007) Reuben Sharma et al.   PROTIST