Motility and more: the flagellum of Trypanosoma brucei

Meiosis and Haploid Gametes in the Pathogen Trypanosoma brucei

(2014) Lori Peacock et al.   CURRENT BIOLOGY

The endocytic activity of the flagellar pocket inTrypanosoma bruceiis regulated by an adjacent phosphatidylinositol phosphate kinase

(2014) Lars Demmel et al.   JOURNAL OF CELL SCIENCE

Modes of flagellar assembly in Chlamydomonas reinhardtii and Trypanosoma brucei

(2014) Johanna L Höög et al.   eLife

The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport

(2014) Diego Huet et al.   eLife

Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

(2013) Matthew K. Gould et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Forward motility is essential for trypanosome infection in the tsetse fly

(2013) Brice Rotureau et al.   CELLULAR MICROBIOLOGY

Mouse infection and pathogenesis byTrypanosoma bruceimotility mutants

(2013) Neville K. Kisalu et al.   CELLULAR MICROBIOLOGY

CMF22 Is a Broadly Conserved Axonemal Protein and Is Required for Propulsive Motility in Trypanosoma brucei

(2013) HoangKim T. Nguyen et al.   EUKARYOTIC CELL

The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility

(2013) Ryosuke Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Flagellar adhesion in Trypanosoma brucei relies on interactions between different skeletal structures in the flagellum and cell body

(2013) B. Rotureau et al.   JOURNAL OF CELL SCIENCE

A cell-body groove housing the new flagellum tip suggests an adaptation of cellular morphogenesis for parasitism in the bloodstream form of Trypanosoma brucei

(2013) Louise Hughes et al.   JOURNAL OF CELL SCIENCE

Stable transformation of pleomorphic bloodstream form Trypanosoma brucei

(2013) Paula MacGregor et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes

(2013) Raqual Bower et al.   MOLECULAR BIOLOGY OF THE CELL

Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

(2013) Binny M. Mony et al.   NATURE

The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans

(2013) Maureen Wirschell et al.   NATURE GENETICS

Genomics of Loa loa, a Wolbachia-free filarial parasite of humans

(2013) Christopher A Desjardins et al.   NATURE GENETICS

Beyond insecticides: new thinking on an ancient problem

(2013) Elizabeth A. McGraw et al.   NATURE REVIEWS MICROBIOLOGY

Identification and Characterization of a Stage Specific Membrane Protein Involved in Flagellar Attachment in Trypanosoma brucei

(2013) Katherine Woods et al.   PLoS One

High-speed holographic microscopy of malaria parasites reveals ambidextrous flagellar waveforms

(2013) L. G. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avalanche-like behavior in ciliary import

(2013) W. B. Ludington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calmodulin is Required for Paraflagellar Rod Assembly and Flagellum-Cell Body Attachment in Trypanosomes

(2013) Michael L. Ginger et al.   PROTIST

Determinants of GPI-PLC Localisation to the Flagellum and Access to GPI-Anchored Substrates in Trypanosomes

(2013) Jack Sunter et al.   PLoS Pathogens

A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei

(2012) Helen P. Price et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The ciliary pocket

(2012) Alexandre Benmerah   CURRENT OPINION IN CELL BIOLOGY

Cytokinesis in trypanosomes

(2012) Helen Farr et al.   Cytoskeleton

A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly

(2012) B. Rotureau et al.   DEVELOPMENT

An intracellular membrane junction consisting of flagellum adhesion glycoproteins links flagellum biogenesis to cell morphogenesis in Trypanosoma brucei

(2012) S. Y. Sun et al.   JOURNAL OF CELL SCIENCE

Intraflagellar transport proteins cycle between the flagellum and its base

(2012) Johanna Buisson et al.   JOURNAL OF CELL SCIENCE

Polo-like kinase is necessary for flagellum inheritance in Trypanosoma brucei

(2012) Kyojiro N. Ikeda et al.   JOURNAL OF CELL SCIENCE

Comparative structural analysis of eukaryotic flagella and cilia from Chlamydomonas, Tetrahymena, and sea urchins

(2012) Gaia Pigino et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cryo-electron tomography and 3-D analysis of the intact flagellum in Trypanosoma brucei

(2012) Johanna L. Höög et al.   JOURNAL OF STRUCTURAL BIOLOGY

Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)

(2012) Peter GE Kennedy   LANCET NEUROLOGY

The CSC connects three major axonemal complexes involved in dynein regulation

(2012) Thomas Heuser et al.   MOLECULAR BIOLOGY OF THE CELL

Late Stage Infection in Sleeping Sickness

(2012) Hartwig Wolburg et al.   PLoS One

Three-Dimensional Structure of the Trypanosome Flagellum Suggests that the Paraflagellar Rod Functions as a Biomechanical Spring

(2012) Louise C. Hughes et al.   PLoS One

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

Early Invasion of Brain Parenchyma by African Trypanosomes

(2012) Ute Frevert et al.   PLoS One

Adenylate Cyclases of Trypanosoma brucei Inhibit the Innate Immune Response of the Host

(2012) D. Salmon et al.   SCIENCE

Developmental Progression to Infectivity in Trypanosoma brucei Triggered by an RNA-Binding Protein

(2012) N. G. Kolev et al.   SCIENCE

Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal

(2012) Vincent Jamonneau et al.   PLoS Neglected Tropical Diseases

Trypanosome Motion Represents an Adaptation to the Crowded Environment of the Vertebrate Bloodstream

(2012) Niko Heddergott et al.   PLoS Pathogens

Transmission Stages Dominate Trypanosome Within-Host Dynamics during Chronic Infections

(2011) Paula MacGregor et al.   Cell Host & Microbe

Structure-Function Analysis of Dynein Light Chain 1 Identifies Viable Motility Mutants in Bloodstream-Form Trypanosoma brucei

(2011) Katherine S. Ralston et al.   EUKARYOTIC CELL

Building Blocks of the Nexin-Dynein Regulatory Complex inChlamydomonasFlagella

(2011) Jianfeng Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trypanosoma bruceiMetacaspase 4 Is a Pseudopeptidase and a Virulence Factor

(2011) William R. Proto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tracing the origins of centrioles, cilia, and flagella

(2011) Zita Carvalho-Santos et al.   JOURNAL OF CELL BIOLOGY

A coiled-coil- and C2-domain-containing protein is required for FAZ assembly and cell morphology in Trypanosoma brucei

(2011) Q. Zhou et al.   JOURNAL OF CELL SCIENCE

Independent Analysis of the Flagellum Surface and Matrix Proteomes Provides Insight into Flagellum Signaling in Mammalian-infectiousTrypanosoma brucei

(2011) Michael Oberholzer et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of the meiotic life cycle stage ofTrypanosoma bruceiin the tsetse fly

(2011) Lori Peacock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Trypanosoma brucei flagellum accounts for its bihelical motion

(2011) A. Y. Koyfman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Microscopic Motility on the Swimming Behavior of Parasites: Straighter Trypanosomes are More Directional

(2011) Sravanti Uppaluri et al.   PLoS Computational Biology

The Genome of Naegleria gruberi Illuminates Early Eukaryotic Versatility

(2010) Lillian K. Fritz-Laylin et al.   CELL

Molecular bases of cytoskeleton plasticity during the Trypanosoma brucei parasite cycle

(2010) Brice Rotureau et al.   CELLULAR MICROBIOLOGY

Composition and sensory function of the trypanosome flagellar membrane

(2010) Danijela Maric et al.   CURRENT OPINION IN MICROBIOLOGY

Assembly of the flagellum and its role in cell morphogenesis in Trypanosoma brucei

(2010) Sue Vaughan   CURRENT OPINION IN MICROBIOLOGY

Calflagin Inhibition Prolongs Host Survival and Suppresses Parasitemia in Trypanosoma brucei Infection

(2010) Brian T. Emmer et al.   EUKARYOTIC CELL

CMF70 is a subunit of the dynein regulatory complex

(2010) Z. P. Kabututu et al.   JOURNAL OF CELL SCIENCE

Sensory reception is an attribute of both primary cilia and motile cilia

(2010) R. A. Bloodgood   JOURNAL OF CELL SCIENCE

Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor

(2010) R. Kieft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trypanosoma brucei Modifies the Tsetse Salivary Composition, Altering the Fly Feeding Behavior That Favors Parasite Transmission

(2010) Jan Van Den Abbeele et al.   PLoS Pathogens

Social Motility in African Trypanosomes

(2010) Michael Oberholzer et al.   PLoS Pathogens

The Trypanosoma brucei Flagellum: Moving Parasites in New Directions

(2009) Katherine S. Ralston et al.   Annual Review of Microbiology

The Vertebrate Primary Cilium in Development, Homeostasis, and Disease

(2009) Jantje M. Gerdes et al.   CELL

The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?

(2009) Brice Rotureau et al.   CELLULAR MICROBIOLOGY

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

The paraflagellar rod of kinetoplastid parasites: From structure to components and function

(2009) Neil Portman et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Kinesin 9 family members perform separate functions in the trypanosome flagellum

(2009) Raphaël Demonchy et al.   JOURNAL OF CELL BIOLOGY

The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella

(2009) Thomas Heuser et al.   JOURNAL OF CELL BIOLOGY

Identification of a palmitoyl acyltransferase required for protein sorting to the flagellar membrane

(2009) B. T. Emmer et al.   JOURNAL OF CELL SCIENCE

Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography

(2009) S. Lacomble et al.   JOURNAL OF CELL SCIENCE

Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans

(2009) Brian J. Haas et al.   NATURE

Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

(2009) Francesca Finetti et al.   NATURE CELL BIOLOGY

The trypanosome flagellar pocket

(2009) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Membrane domains and flagellar pocket boundaries are influenced by the cytoskeleton in African trypanosomes

(2009) C. Gadelha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Propulsion of African trypanosomes is driven by bihelical waves with alternating chirality separated by kinks

(2009) J. A. Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly

(2009) Reuben Sharma et al.   TRENDS IN PARASITOLOGY

The Aurora Kinase in Trypanosoma brucei Plays Distinctive Roles in Metaphase-Anaphase Transition and Cytokinetic Initiation

(2009) Ziyin Li et al.   PLoS Pathogens

Combining RNA Interference Mutants and Comparative Proteomics to Identify Protein Components and Dependences in a Eukaryotic Flagellum

(2008) Neil Portman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetoplastids: related protozoan pathogens, different diseases

(2008) Ken Stuart et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a Novel Chromosomal Passenger Complex and Its Unique Localization during Cytokinesis in Trypanosoma brucei

(2008) Ziyin Li et al.   PLoS One

A Haptoglobin-Hemoglobin Receptor Conveys Innate Immunity to Trypanosoma brucei in Humans

(2008) B. Vanhollebeke et al.   SCIENCE

Biogenesis of the Trypanosome Endo-Exocytotic Organelle Is Cytoskeleton Mediated

(2008) Mélanie Bonhivers et al.   PLOS BIOLOGY

Eliminating Human African Trypanosomiasis: Where Do We Stand and What Comes Next?

(2008) Pere P Simarro et al.   PLOS MEDICINE

Intraflagellar Transport and Functional Analysis of Genes Required for Flagellum Formation in Trypanosomes

(2007) Sabrina Absalon et al.   MOLECULAR BIOLOGY OF THE CELL

Asymmetric Cell Division as a Route to Reduction in Cell Length and Change in Cell Morphology in Trypanosomes

(2007) Reuben Sharma et al.   PROTIST

A Repetitive Protein Essential for the Flagellum Attachment Zone Filament Structure and Function in Trypanosoma brucei

(2007) Sue Vaughan et al.   PROTIST