Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma

Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury

(2022) Qiyu Qin et al.   Cell Death & Disease

Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma

(2022) Fei Yao et al.   CELL DEATH AND DIFFERENTIATION

Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model

(2022) Dan Ye et al.   JOURNAL OF PINEAL RESEARCH

Modulating antioxidant systems as a therapeutic approach to retinal degeneration

(2022) Xiaoyuan Ren et al.   Redox Biology

Mitochondrial Dysfunction in a High Intraocular Pressure-Induced Retinal Ischemia Minipig Model

(2022) Michael Pasák et al.   Biomolecules

Role of CAST-Drp1 Pathway in Retinal Neuron-Regulated Necrosis in Experimental Glaucoma

(2022) Su-mei Liu et al.   Current Medical Science

Dephosphorylation of ERK1/2 and DRP1 S585 regulates mitochondrial dynamics in glutamate toxicity of retinal neurons in vitro

(2022) Zhou Zeng et al.   EXPERIMENTAL EYE RESEARCH

Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma

(2022) Henrik Tonner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PANoptosis: new insights in regulated cell death in ischemia/reperfusion models

(2022) Arsenio Fernández-López et al.   Neural Regeneration Research

Glaucoma in Adults—Screening, Diagnosis, and Management

(2021) Joshua D. Stein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Glaucoma Heritability: Molecular Mechanisms of Disease

(2021) Ryan Zukerman et al.   Genes

Imbalanced GSH/ROS and sequential cell death

(2021) Ting Liu et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The cell biology of mitochondrial membrane dynamics

(2020) Marta Giacomello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells

(2020) Genea Edwards et al.   Cell Death & Disease

Optogenetic stimulation of phosphoinositides reveals a critical role of primary cilia in eye pressure regulation

(2020) Philipp P. Prosseda et al.   Science Advances

The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Parimal Samir et al.   Frontiers in Cellular and Infection Microbiology

Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy

(2020) Rong Rong et al.   Cell Death & Disease

LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury

(2019) Peixing Wan et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Dynamics and Its Involvement in Disease

(2019) David C. Chan   Annual Review of Pathology-Mechanisms of Disease

Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy

(2018) Niina Piippo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Kaempferol attenuates retinal ganglion cell death by suppressing NLRP1/NLRP3 inflammasomes and caspase-8 via JNK and NF-κB pathways in acute glaucoma

(2018) Chaobin Lin et al.   EYE

GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

(2018) Huazhang Zhu et al.   Molecular Neurodegeneration

A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model

(2017) Yun-Ju Do et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial fusion, fission, and mitochondrial toxicity

(2017) Joel N. Meyer et al.   TOXICOLOGY

Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt

(2016) Dejuan Kong et al.   EXPERIMENTAL EYE RESEARCH

CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death

(2015) Arezu Jahani-Asl et al.   HUMAN MOLECULAR GENETICS

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

(2015) Y Ha et al.   Cell Death & Disease

DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma

(2015) K-Y Kim et al.   Cell Death & Disease

The Pathophysiology and Treatment of Glaucoma

(2014) Robert N. Weinreb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

RNAi screening identifies GSK3β as a regulator of DRP1 and the neuroprotection of lithium chloride against elevated pressure involved in downregulation of DRP1

(2013) Ji-Hong Wu et al.   NEUROSCIENCE LETTERS

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH