Glaucoma Heritability: Molecular Mechanisms of Disease

Glial Cells in Glaucoma: Friends, Foes, and Potential Therapeutic Targets

(2021) Mariana Y. García-Bermúdez et al.   Frontiers in Neurology

Use of Gene Therapy in Retinal Ganglion Cell Neuroprotection: Current Concepts and Future Directions

(2021) Jess Rhee et al.   Biomolecules

Large-scale machine-learning-based phenotyping significantly improves genomic discovery for optic nerve head morphology

(2021) Babak Alipanahi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in >280,000 images from UKB and CLSA

(2021) Xikun Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gene Therapy for Glaucoma by Ciliary Body Aquaporin 1 Disruption Using CRISPR-Cas9

(2020) Jiahui Wu et al.   MOLECULAR THERAPY

TheAtoh7remote enhancer provides transcriptional robustness during retinal ganglion cell development

(2020) Joel B. Miesfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Genetics of Glaucoma: Subtype and Ethnicity Considerations

(2020) Ryan Zukerman et al.   Genes

Retinal and optic nerve degeneration in liver X receptor β knockout mice

(2019) Xiao-yu Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heritability of glaucoma and glaucoma-related endophenotypes: Systematic review and meta-analysis

(2019) Nigus Gebremedhin Asefa et al.   SURVEY OF OPHTHALMOLOGY

Genome-wide association analysis of 95,549 individuals identifies novel loci and genes influencing optic disc morphology

(2019) Xikun Han et al.   HUMAN MOLECULAR GENETICS

Genome-wide association analyses identify new loci influencing intraocular pressure

(2018) X Raymond Gao et al.   HUMAN MOLECULAR GENETICS

Genetic Risk Score Is Associated with Vertical Cup-to-Disc Ratio and Improves Prediction of Primary Open-Angle Glaucoma in Latinos

(2018) Drew R. Nannini et al.   OPHTHALMOLOGY

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

(2018) Hélène Choquet et al.   Nature Communications

Reduced Annexin A1 Secretion by ABCA1 Causes Retinal Inflammation and Ganglion Cell Apoptosis in a Murine Glaucoma Model

(2018) Lu Li et al.   Frontiers in Cellular Neuroscience

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: a multi-cohort analysis

(2017) Hugues Aschard et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics.

(2017) Henriët Springelkamp et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

(2017) Beatrice S Melin et al.   NATURE GENETICS

Atoh7 promotes the differentiation of Müller cells-derived retinal stem cells into retinal ganglion cells in a rat model of glaucoma

(2015) Wei-tao Song et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Activation of Liver X Receptor Protects Inner Retinal Damage Induced by N-methyl-D-aspartate

(2015) S. Zheng et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Septin Form and Function at the Cell Cortex

(2015) Andrew A. Bridges et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological interpretation of genome-wide association studies using predicted gene functions

(2015) Tune H. Pers et al.   Nature Communications

ABCA1 and nascent HDL biogenesis

(2014) Shuhui Wang et al.   BIOFACTORS

The Pathophysiology and Treatment of Glaucoma

(2014) Robert N. Weinreb et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma

(2014) Puya Gharahkhani et al.   NATURE GENETICS

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

(2014) Pirro G Hysi et al.   NATURE GENETICS

Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma

(2014) Yuhong Chen et al.   NATURE GENETICS

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

(2014) Henriët. Springelkamp et al.   Nature Communications

A Dominant-Negative Mutation of Mouse Lmx1b Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation

(2014) Sally H. Cross et al.   PLoS Genetics

From observational to dynamic genetics

(2014) Claire M. A. Haworth et al.   Frontiers in Genetics

Comparative Effectiveness of Treatments for Open-Angle Glaucoma: A Systematic Review for the U.S. Preventive Services Task Force

(2013) Michael V. Boland et al.   ANNALS OF INTERNAL MEDICINE

Do Findings on Routine Examination Identify Patients at Risk for Primary Open-Angle Glaucoma?

(2013) Hussein Hollands et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The heritability of human disease: estimation, uses and abuses

(2013) Albert Tenesa et al.   NATURE REVIEWS GENETICS

Glaucomatous neurodegeneration: An eye on tumor necrosis factor-alpha

(2012) Renu Agarwal et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

Normal-tension glaucoma (Low-tension glaucoma)

(2010) DouglasR Anderson   INDIAN JOURNAL OF OPHTHALMOLOGY

A Genome-Wide Association Study of Optic Disc Parameters

(2010) Wishal D. Ramdas et al.   PLoS Genetics

The presence and distribution of elastin in the posterior and retrobulbar regions of the mouse eye

(2009) Scott Gelman et al.   EXPERIMENTAL EYE RESEARCH

The Relationship between Intraocular Pressure and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma

(2009) Felipe A. Medeiros et al.   OPHTHALMOLOGY

Direct Interaction of Nuclear Liver X Receptor-β with ABCA1 Modulates Cholesterol Efflux

(2008) Masako Hozoji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY