Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis

Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment

(2022) Mi Zhang et al.   Materials Today Bio

Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome

(2022) Lei Zhang et al.   ADVANCED MATERIALS

Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage

(2021) Sean K. Bedingfield et al.   Nature Biomedical Engineering

Enhanced cancer therapeutic efficiency of NO combined with siRNA by caspase-3 responsive polymers

(2021) Yi Yan et al.   JOURNAL OF CONTROLLED RELEASE

Macrophages regulate the progression of osteoarthritis

(2020) H. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Intra-articular corticosteroid injections increase the risk of requiring knee arthroplasty

(2020) Stan R. W. Wijn et al.   Bone & Joint Journal

Therapeutic Manipulation of Macrophages Using Nanotechnological Approaches for the Treatment of Osteoarthritis

(2020) Aldo Ummarino et al.   Nanomaterials

Biological activities of siRNA-loaded lanthanum phosphate nanoparticles on colorectal cancer

(2020) Piao-Piao Li et al.   JOURNAL OF CONTROLLED RELEASE

Degenerative osteoarthritis a reversible chronic disease

(2020) V. Di Nicola   Regenerative Therapy

Hyaluronic Acid-Based Activatable Nanomaterials for Stimuli-Responsive Imaging and Therapeutics: Beyond CD44-Mediated Drug Delivery

(2019) Ki Young Choi et al.   ADVANCED MATERIALS

Organic Photodynamic Nanoinhibitor for Synergistic Cancer Therapy

(2019) Yuyan Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Targeted delivery of hesperetin to cartilage attenuates osteoarthritis by bimodal imaging with Gd2(CO3)3@PDA nanoparticles via TLR-2/NF-κB/Akt signaling

(2019) Zhengxiao Ouyang et al.   BIOMATERIALS

Macrophage M1/M2 polarization and rheumatoid arthritis: A systematic review

(2019) Samuele Tardito et al.   AUTOIMMUNITY REVIEWS

Articular Cartilage Regeneration in Osteoarthritis

(2019) Livia Roseti et al.   Cells

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

(2019) Yue Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Treatment of hip osteoarthritis with glucocorticoids

(2018) Jian Zhou et al.   ANNALS OF THE RHEUMATIC DISEASES

Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes

(2018) Meilu Dai et al.   BIOMATERIALS

Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers

(2018) Miaorong Yu et al.   Nature Communications

Redox and NF-κB signaling in osteoarthritis

(2018) Panagiotis Lepetsos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decursinol Angelate Inhibits LPS-Induced Macrophage Polarization through Modulation of the NFκB and MAPK Signaling Pathways

(2018) Salman Islam et al.   MOLECULES

Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach

(2017) Hyo Sung Jung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The minor collagens in articular cartilage

(2017) Yunyun Luo et al.   Protein & Cell

Injectable and thermosensitive TGF-β1-loaded PCEC hydrogel system for in vivo cartilage repair

(2017) Tengfei Zhou et al.   Scientific Reports

Advances in Hyaluronic Acid-Based Drug Delivery Systems

(2016) Yan Jiao et al.   CURRENT DRUG TARGETS

Dexamethasone downregulates expression of carbonic anhydrase IX via HIF-1α and NF-κB-dependent mechanisms

(2016) Veronika Simko et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Systemic delivery of siRNA by hyaluronan-functionalized calcium phosphate nanoparticles for tumor-targeted therapy

(2016) Chong Qiu et al.   Nanoscale

Direct in vivo evidence of activated macrophages in human osteoarthritis

(2016) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future

(2016) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Type II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-β1

(2015) Hyun Joo Yoon et al.   BMC MUSCULOSKELETAL DISORDERS

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

(2015) E. W. Orlowsky et al.   JOURNAL OF RHEUMATOLOGY

Viscosupplementation for Osteoarthritis of the Knee

(2015) David J. Hunter   NEW ENGLAND JOURNAL OF MEDICINE

Arthritic and non-arthritic synovial fluids modulate IL10 and IL1RA gene expression in differentially activated primary human monocytes

(2015) S. Lopa et al.   OSTEOARTHRITIS AND CARTILAGE

Tunable Rigidity of (Polymeric Core)-(Lipid Shell) Nanoparticles for Regulated Cellular Uptake

(2014) Jiashu Sun et al.   ADVANCED MATERIALS

MMP13 is a critical target gene during the progression of osteoarthritis

(2013) Meina Wang et al.   ARTHRITIS RESEARCH & THERAPY

Nitric Oxide Turn-on Fluorescent Probe Based on Deamination of Aromatic Primary Monoamines

(2012) Tsun-Wei Shiue et al.   INORGANIC CHEMISTRY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

(2011) Y. Lou et al.   CANCER RESEARCH

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee

(2011) J.S. Lewis et al.   OSTEOARTHRITIS AND CARTILAGE

Control of Macrophage Activation and Function by PPARs

(2010) Ajay Chawla   CIRCULATION RESEARCH

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rat

(2010) N. Gerwin et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY