Therapeutic Manipulation of Macrophages Using Nanotechnological Approaches for the Treatment of Osteoarthritis

The role of macrophages in osteoarthritis and cartilage repair

(2020) C.-L. Wu et al.   OSTEOARTHRITIS AND CARTILAGE

Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee

(2020) K.N. Bailey et al.   OSTEOARTHRITIS AND CARTILAGE

Nanotechnological Strategies for Osteoarthritis Diagnosis, Monitoring, Clinical Management, and Regenerative Medicine: Recent Advances and Future Opportunities

(2020) Reza Mohammadinejad et al.   Current Rheumatology Reports

Combination of Hyaluronic Acid and PLGA Particles as Hybrid Systems for Viscosupplementation in Osteoarthritis

(2019) Ana Henriques Mota et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dexamethasone palmitate nanoparticles: An efficient treatment for rheumatoid arthritis

(2019) Mathilde Lorscheider et al.   JOURNAL OF CONTROLLED RELEASE

Antioxidant Properties of Fullerene Derivatives Depend on Their Chemical Structure: A Study of Two Fullerene Derivatives on HELFs

(2019) Vasilina Sergeeva et al.   Oxidative Medicine and Cellular Longevity

Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis

(2019) Quanbo Ji et al.   Nature Communications

A Phase 2 Trial of Lutikizumab, an Anti-Interleukin 1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis

(2019) Roy M. Fleischmann et al.   Arthritis & Rheumatology

Selenium Nanoparticles Dispersed in Phytochemical Exert Anti-Inflammatory Activity by Modulating Catalase, GPx1, and COX-2 Gene Expression in a Rheumatoid Arthritis Rat Model

(2019) Shi-Xiang Ren et al.   MEDICAL SCIENCE MONITOR

Liposome-encapsulated fish oil protein-tagged gold nanoparticles for intra-articular therapy in osteoarthritis

(2019) Amrita Sarkar et al.   Nanomedicine

Poly(ester amide) particles for controlled delivery of celecoxib

(2019) Ian J. Villamagna et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee

(2019) Jinwei Xie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Injectable biomaterials for delivery of interleukin-1 receptor antagonist: Toward improving its therapeutic effect

(2019) Anna E.B. Clements et al.   Acta Biomaterialia

The Interplay between Blood Proteins, Complement, and Macrophages on Nanomedicine Performance and Responses

(2019) Seyed Moein Moghimi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Osteoarthritis

(2019) David J Hunter et al.   LANCET

High Molecular Weight Hyaluronan Suppresses Macrophage M1 Polarization and Enhances IL-10 Production in PM2.5-Induced Lung Inflammation

(2019) Qiwen Shi et al.   MOLECULES

Therapeutic options for targeting inflammatory osteoarthritis pain

(2019) Philip G. Conaghan et al.   Nature Reviews Rheumatology

Active Nano-targeting of Macrophages

(2019) Natasa Gaspar et al.   CURRENT PHARMACEUTICAL DESIGN

Antioxidative nanofullerol inhibits macrophage activation and development of osteoarthritis in rats

(2019) Yilun Pei et al.   International Journal of Nanomedicine

Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee

(2019) Thomas J. Schnitzer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

(2019) R.R. Bannuru et al.   OSTEOARTHRITIS AND CARTILAGE

Co-culture of osteochondral explants and synovial membrane as in vitro model for osteoarthritis

(2019) Eva Haltmayer et al.   PLoS One

Adenosine-Functionalized Biodegradable PLA-b-PEG Nanoparticles Ameliorate Osteoarthritis in Rats

(2019) Xiuling Liu et al.   Scientific Reports

The Efficacy, Tolerability and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Double-blind, Placebo-controlled, Randomized Clinical Trial

(2019) Paula Dakin et al.   Arthritis & Rheumatology

Dissecting the Dual Nature of Hyaluronan in the Tumor Microenvironment

(2019) Muhan Liu et al.   Frontiers in Immunology

Could GILZ Be the Answer to Glucocorticoid Toxicity in Lupus?

(2019) Jacqueline K. Flynn et al.   Frontiers in Immunology

Injectable mechanical pillows for attenuation of load-induced post-traumatic osteoarthritis

(2019) Derek T Holyoak et al.   Regenerative Biomaterials

Carbohydrate-based nanocarriers and their application to target macrophages and deliver antimicrobial agents

(2019) Tamim Mosaiab et al.   ADVANCED DRUG DELIVERY REVIEWS

Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2

(2019) Huimin Li et al.   ADVANCED MATERIALS

Triamcinolone acetonide-loaded PLA/PEG-PDL microparticles for effective intra-articular delivery: synthesis, optimization, in vitro and in vivo evaluation

(2019) May Abou-ElNour et al.   JOURNAL OF CONTROLLED RELEASE

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Nanoparticles Targeting Macrophages as Potential Clinical Therapeutic Agents Against Cancer and Inflammation

(2019) Guorong Hu et al.   Frontiers in Immunology

Treatment with synthetic glucocorticoid impairs bone metabolism, as revealed by in vivo imaging of osteoblasts and osteoclasts in medaka fish

(2019) Yuki Azetsu et al.   BIOMEDICINE & PHARMACOTHERAPY

Non-operative treatment options for knee osteoarthritis

(2019) Michael DeRogatis et al.   Annals of Translational Medicine

Modified ZIF-8 Nanoparticles Attenuate Osteoarthritis by Reprogramming the Metabolic Pathway of Synovial Macrophages

(2019) Feng Zhou et al.   ACS Applied Materials & Interfaces

Sustained low-dose dexamethasone delivery via a PLGA microsphere-embedded agarose implant for enhanced osteochondral repair

(2019) Robert M. Stefani et al.   Acta Biomaterialia

Acid-activatable polymeric curcumin nanoparticles as therapeutic agents for osteoarthritis

(2019) Changsun Kang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Osteogenesis potential of different titania nanotubes in oxidative stress microenvironment

(2018) Yonglin Yu et al.   BIOMATERIALS

Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes

(2018) Meilu Dai et al.   BIOMATERIALS

Chondroprotective Effects of Hyaluronic Acid-Chitosan Nanoparticles Containing Plasmid DNA Encoding Cytokine Response Modifier A in a Rat Knee Osteoarthritis Model

(2018) Pang-hu Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mixed Treatment Comparisons for Nonsurgical Treatment of Knee Osteoarthritis

(2018) David S. Jevsevar et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis – the HUMOR trial

(2018) D. Aitken et al.   OSTEOARTHRITIS AND CARTILAGE

Non-variceal upper gastrointestinal bleeding

(2018) Angel Lanas et al.   Nature Reviews Disease Primers

Biomimetic nanoparticles for inflammation targeting

(2018) Kai Jin et al.   Acta Pharmaceutica Sinica B

Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis

(2018) Weifeng Duan et al.   JOURNAL OF NANOBIOTECHNOLOGY

Restoration Effect and Tribological Behavior of Hyaluronic Acid Reinforced with Graphene Oxide in Osteoarthritis

(2018) Aifeng Liu et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

In Vitro Evaluation of Hybrid Cooperative Complexes of Hyaluronic Acid as a Potential New Ophthalmic Treatment

(2018) Annalisa La Gatta et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Models of osteoarthritis: the good, the bad and the promising

(2018) P.J. Cope et al.   OSTEOARTHRITIS AND CARTILAGE

The contribution of synovial macrophages to rat advanced osteoarthritis pain resistant to cyclooxygenase inhibitors

(2018) Yusuke Sakurai et al.   PAIN

Imbalance of M1/M2 macrophages is linked to severity level of knee osteoarthritis

(2018) Baolong Liu et al.   Experimental and Therapeutic Medicine

Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential

(2017) Yeon Kyung Lee et al.   International Journal of Nanomedicine

Delivery of anti-inflammatory peptides from hollow PEGylated poly(NIPAM) nanoparticles reduces inflammation in an ex vivo osteoarthritis model

(2017) James McMasters et al.   JOURNAL OF CONTROLLED RELEASE

Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: An open-label randomized controlled trial

(2017) Jianping Wang   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

(2017) Peter Popp Wibroe et al.   Nature Nanotechnology

The STR/ort mouse model of spontaneous osteoarthritis – an update

(2017) K.A. Staines et al.   OSTEOARTHRITIS AND CARTILAGE

Targeting tumor associated macrophages: The new challenge for nanomedicine

(2017) Fernando Torres Andón et al.   SEMINARS IN IMMUNOLOGY

Nanoparticles and innate immunity: new perspectives on host defence

(2017) Diana Boraschi et al.   SEMINARS IN IMMUNOLOGY

Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression

(2017) Carmen Corciulo et al.   Nature Communications

Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis

(2016) Mi-Lan Kang et al.   Acta Biomaterialia

Prevention of Renal Complications Induced by Non- Steroidal Anti-Inflammatory Drugs

(2016) Sonja Vu|kovi| et al.   CURRENT MEDICINAL CHEMISTRY

Hyaluronic acid: Perspectives in dentistry. A systematic review

(2016) Manuele Casale et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Development and optimization of self-assembling nanosystem for intra-articular delivery of indomethacin

(2016) Rabab Kamel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mineralization Effect of Hyaluronan on Dental Pulp Cells via CD44

(2016) Kuan-Liang Chen et al.   JOURNAL OF ENDODONTICS

Regenerative approaches for the treatment of early OA

(2016) L. de Girolamo et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Theo Vos et al.   LANCET

Poly (caprolactone) microparticles and chitosan thermogels based injectable formulation of etoricoxib for the potential treatment of osteoarthritis

(2016) P. Arunkumar et al.   Materials Science & Engineering C-Materials for Biological Applications

Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time-dependent manner: proposed model-specific scoring systems

(2016) M. Udo et al.   OSTEOARTHRITIS AND CARTILAGE

Direct in vivo evidence of activated macrophages in human osteoarthritis

(2016) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Efficacy and safety of oral NSAIDs and analgesics in the management of osteoarthritis: Evidence from real-life setting trials and surveys

(2016) Jean-Pierre Pelletier et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Detection and treatment of atherosclerosis using nanoparticles

(2016) Jia Zhang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection

(2016) Sung Rae Kim et al.   Drug Design Development and Therapy

Hyaluronic acid compared with corticosteroid injections for the treatment of osteoarthritis of the knee: a randomized control trail

(2016) Alireza Askari et al.   SpringerPlus

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages

(2015) Tomasz Olszowski et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Is osteoarthritis a metabolic disorder?

(2015) S. Kluzek et al.   BRITISH MEDICAL BULLETIN

State of the evidence

(2015) Kelli D. Allen et al.   CURRENT OPINION IN RHEUMATOLOGY

Synthesis of self-assembled IL-1Ra-presenting nanoparticles for the treatment of osteoarthritis

(2015) Rachit Agarwal et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

Efficacy of Direct Injection of Etanercept into Knee Joints for Pain in Moderate and Severe Knee Osteoarthritis

(2015) Seiji Ohtori et al.   YONSEI MEDICAL JOURNAL

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials-Science & Engineering

The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation

(2015) Youngmi Kim et al.   Frontiers in Immunology

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials Science & Engineering

Polyethylene-Glycol-Modified Single-Walled Carbon Nanotubes for Intra-Articular Delivery to Chondrocytes

(2014) Cristiano Sacchetti et al.   ACS Nano

Detection of Mycobacterium tuberculosis based on H37Rv binding peptides using surface functionalized magnetic microspheres coupled with quantum dots – a nano detection method for Mycobacterium tuberculosis

(2014) Hua Yang et al.   International Journal of Nanomedicine

Liposomal encapsulation of dexamethasone modulates cytotoxicity, inflammatory cytokine response, and migratory properties of primary human macrophages

(2014) Matthias Bartneck et al.   Nanomedicine-Nanotechnology Biology and Medicine

Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state

(2014) N. Fahy et al.   OSTEOARTHRITIS AND CARTILAGE

Effects of CD14 Macrophages and Proinflammatory Cytokines on Chondrogenesis in Osteoarthritic Synovium-Derived Stem Cells

(2014) Sun Ae Han et al.   TISSUE ENGINEERING PART A

Interleukin 6 and Rheumatoid Arthritis

(2014) Yuji Yoshida et al.   Biomed Research International

New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases

(2014) Ersilia Nigro et al.   Biomed Research International

Is osteoarthritis a metabolic disease?

(2013) Jérémie Sellam et al.   JOINT BONE SPINE

Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials

(2012) Fernando Torres Andón et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hemocompatible Poly(NIPAm-MBA-AMPS) Colloidal Nanoparticles as Carriers of Anti-inflammatory Cell Penetrating Peptides

(2012) Rush L Bartlett et al.   BIOMACROMOLECULES

Tumor Necrosis Factor-α Signaling in Macrophages

(2012) Narayanan Parameswaran et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Diabetes Is an Independent Predictor for Severe Osteoarthritis: Results from a longitudinal cohort study

(2012) G. Schett et al.   DIABETES CARE

Intra-articular delivery of liposomal celecoxib–hyaluronate combination for the treatment of osteoarthritis in rabbit model

(2012) Ji Dong et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cell-penetrating peptides released from thermosensitive nanoparticles suppress pro-inflammatory cytokine response by specifically targeting inflamed cartilage explants

(2012) Rush L. Bartlett et al.   Nanomedicine-Nanotechnology Biology and Medicine

COX-2 Inhibitors and Cardiovascular Risk

(2012) C. P. Cannon et al.   SCIENCE

Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography/computed tomography

(2011) Tom M. Piscaer et al.   ARTHRITIS AND RHEUMATISM

Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis

(2010) Rebecca Anderson et al.   ARTHRITIS RESEARCH & THERAPY

Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-InducedPGE2, IL-6, and IL-8 Production

(2009) Katriina Vuolteenaho et al.   MEDIATORS OF INFLAMMATION

Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer

(2009) Yogeshkumar Malam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

(2008) Bharat B. Aggarwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY