Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus

Viral determinants of influenza A virus host range

(2014) A. V. Cauldwell et al.   JOURNAL OF GENERAL VIROLOGY

Influenza A Virus Acquires Enhanced Pathogenicity and Transmissibility after Serial Passages in Swine

(2014) K. Wei et al.   JOURNAL OF VIROLOGY

Adaptation of a natural reassortant H5N2 avian influenza virus in mice

(2014) Qunhui Li et al.   VETERINARY MICROBIOLOGY

PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice

(2014) Kaihui Cheng et al.   VIROLOGY

Influenza A viruses with different amino acid residues at PB2-627 display distinct replication properties in vitro and in vivo : Revealing the sequence plasticity of PB2-627 position

(2014) Alex W.H. Chin et al.   VIROLOGY

Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts

(2014) Shufang Fan et al.   Nature Communications

Mammalian Adaptation in the PB2 Gene of Avian H5N1 Influenza Virus

(2013) J.-Y. Min et al.   JOURNAL OF VIROLOGY

Rapid emergence of a virulent PB2 E627K variant during adaptation of highly pathogenic avian influenza H7N7 virus to mice

(2013) Rineke MC de Jong et al.   Virology Journal

Transmission of influenza A/H5N1 viruses in mammals

(2013) M. Imai et al.   VIRUS RESEARCH

Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan

(2013) Weifeng Shi et al.   Protein & Cell

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

(2012) H. Thorvaldsdottir et al.   BRIEFINGS IN BIOINFORMATICS

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Genetic characterization of subtype H1 avian influenza viruses isolated from live poultry markets in Zhejiang Province, China, in 2011

(2012) Hai-bo Wu et al.   VIRUS GENES

Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse

(2011) Jihui Ping et al.   PLoS One

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

(2011) Gülsah Gabriel et al.   Nature Communications

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

PB2 Residue 271 Plays a Key Role in Enhanced Polymerase Activity of Influenza A Viruses in Mammalian Host Cells

(2010) K. A. Bussey et al.   JOURNAL OF VIROLOGY

PB2 Residue 158 Is a Pathogenic Determinant of Pandemic H1N1 and H5 Influenza A Viruses in Mice

(2010) B. Zhou et al.   JOURNAL OF VIROLOGY

Complete-Proteome Mapping of Human Influenza A Adaptive Mutations: Implications for Human Transmissibility of Zoonotic Strains

(2010) Olivo Miotto et al.   PLoS One

Characterization of H5N1 influenza viruses isolated from humans in vitro

(2010) Yong-Gang Li et al.   Virology Journal

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

(2010) Shinya Yamada et al.   PLoS Pathogens

Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue

(2009) Takashi Kuzuhara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational Analysis of Conserved Amino Acids in the Influenza A Virus Nucleoprotein

(2009) Z. Li et al.   JOURNAL OF VIROLOGY

The Polymerase Acidic Protein Gene of Influenza A Virus Contributes to Pathogenicity in a Mouse Model

(2009) M.-S. Song et al.   JOURNAL OF VIROLOGY

Hemagglutinin-Pseudotyped Green Fluorescent Protein-Expressing Influenza Viruses for the Detection of Influenza Virus Neutralizing Antibodies

(2009) L. Martinez-Sobrido et al.   JOURNAL OF VIROLOGY

Adaptive strategies of the influenza virus polymerase for replication in humans

(2009) Andrew Mehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2

(2009) Junwei Li et al.   VIRUS RESEARCH

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens

Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice

(2008) Shufang Fan et al.   VIROLOGY

Genetic characterization of avian influenza viruses isolated in Israel during 2000–2006

(2008) Natalia Golender et al.   VIRUS GENES