Panax notoginseng saponins inhibits NLRP3 inflammasome-mediated pyroptosis by downregulating lncRNA-ANRIL in cardiorenal syndrome type 4

METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA

(2022) Liping Meng et al.   Cell Death & Disease

Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation

(2022) Chenyang Zhang et al.   Journal of the American Heart Association

The Effect of Sacubitril/Valsartan Treatment on Cardiac and Renal Functions of a Patient With Cardiorenal Syndrome Type 4 and Stage 5 CKD After More Than Three Years of Follow-Up

(2022) Shuiqin Cheng et al.   Frontiers in Medicine

LncRNA ANRIL mediates endothelial dysfunction through BDNF downregulation in chronic kidney disease

(2022) Hong Su et al.   Cell Death & Disease

Panax notoginseng extract and total saponin suppress diet-induced obesity and endoplasmic reticulum stress in epididymal white adipose tissue in mice

(2022) Yi Tan et al.   Chinese Medicine

Efficacy and Safety of Wuling Powder in the Treatment of Patients with Diabetic Nephropathy: A Systematic Review and Meta-Analysis

(2022) Yunyi Yang et al.   Evidence-based Complementary and Alternative Medicine

LncRNA ANRIL-mediated miR-181b-5p/S1PR1 axis is involved in the progression of uremic cardiomyopathy through activating T cells

(2022) Ying Xu et al.   Scientific Reports

Panax notoginseng saponins alleviate damage to the intestinal barrier and regulate levels of intestinal microbes in a rat model of chronic kidney disease

(2022) Jing Xie et al.   RENAL FAILURE

Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

(2021) Yuanjie Li et al.   Journal of Neuroinflammation

lncRNA‑MALAT1 promotes high glucose‑induced H9C2 cardiomyocyte pyroptosis by downregulating miR‑141‑3p expression

(2021) Aishan Wu et al.   Molecular Medicine Reports

Soluble Epoxide Hydrolase Inhibition Prevents Experimental Type 4 Cardiorenal Syndrome

(2021) Mouad Hamzaoui et al.   Frontiers in Molecular Biosciences

Cardioprotection of Panax Notoginseng saponins against acute myocardial infarction and heart failure through inducing autophagy

(2021) Dandan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury

(2021) Huairui Shi et al.   CIRCULATION RESEARCH

Panax notoginseng saponins protect H9c2 cells from hypoxia-reoxygenation injury through FOXO3a/HIF-1α cell signaling pathway

(2021) Xin-Wen Liu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Mechanism of lncRNA-ANRIL/miR-181b in autophagy of cardiomyocytes in mice with uremia by targeting ATG5

(2021) Ying Xu et al.   PLoS One

Effect of the combination of astragaloside IV and Panax notoginseng saponins on pyroptosis and necroptosis in rat models of cerebral ischemia‑reperfusion

(2021) Biao Tang et al.   Experimental and Therapeutic Medicine

Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease

(2021) Nan Ji et al.   Journal of Inflammation Research

LncRNA PVT1 Knockdown Ameliorates Myocardial Ischemia Reperfusion Damage via Suppressing Gasdermin D-Mediated Pyroptosis in Cardiomyocytes

(2021) Cuizhi Li et al.   Frontiers in Cardiovascular Medicine

Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway

(2021) Qingqing Li et al.   BIOMEDICINE & PHARMACOTHERAPY

The Role of the Inflammasome in Heart Failure

(2021) Jimin Wu et al.   Frontiers in Physiology

BMP-7 Attenuates Inflammation-Induced Pyroptosis and Improves Cardiac Repair in Diabetic Cardiomyopathy

(2021) Ibrahim Elmadbouh et al.   Cells

MiR-30c-5p mediates the effects of panax notoginseng saponins in myocardial ischemia reperfusion injury by inhibiting oxidative stress-induced cell damage

(2020) Linli Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury

(2020) Yuan Chang et al.   Journal of Neuroinflammation

Long non-coding RNAs: from disease code to drug role

(2020) Yuanyuan Chen et al.   Acta Pharmaceutica Sinica B

Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway

(2020) Jing Zhang et al.   Aging-US

Global gene expression analysis using RNA-seq reveals the new roles of Panax notoginseng Saponins in ischemic cardiomyocytes

(2020) Shaoxian Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Panax Notoginseng Saponins Protect Cardiac Myocytes Against Endoplasmic Reticulum Stress and Associated Apoptosis Through Mediation of Intracellular Calcium Homeostasis

(2019) Jun Chen et al.   Frontiers in Pharmacology

LncRNA ANRIL knockdown relieves myocardial cell apoptosis in acute myocardial infarction by regulating IL-33/ST2

(2019) Jinhua Yang et al.   CELL CYCLE

LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis

(2019) Qing Mao et al.   Stem Cell Research & Therapy

Role of pyroptosis in cardiovascular disease

(2018) Zeng Zhaolin et al.   CELL PROLIFERATION

Mechanisms and Modulation of Oxidative/Nitrative Stress in Type 4 Cardio-Renal Syndrome and Renal Sarcopenia

(2018) Márta Sárközy et al.   Frontiers in Physiology

Simvastatin Ameliorates Diabetic Cardiomyopathy by Attenuating Oxidative Stress and Inflammation in Rats

(2017) Nawal M. Al-Rasheed et al.   Oxidative Medicine and Cellular Longevity

Visualizing myocardial inflammation in a rat model of type 4 cardiorenal syndrome by dual-modality molecular imaging

(2015) Di Chang et al.   BIOMATERIALS