Review
Biochemistry & Molecular Biology
Chiara Siracusa, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Marek Postula, Salvatore De Rosa
Summary: Lack of timely intervention strategies for acute ischemic stroke due to limited understanding of underlying mechanisms. Circular RNAs involved in pathophysiological processes of ischemic stroke, providing potential therapeutic targets and clinical biomarkers.
Review
Cardiac & Cardiovascular Systems
Sara Fadaei, Fatemeh Zarepour, Mehrnoosh Parvaresh, Alireza Motamedzadeh, Seyed Saeed Tamehri Zadeh, Amirhossein Sheida, Mohammad Shabani, Michael R. Hamblin, Mehdi Rezaee, Maryam Zarei, Hamed Mirzaei
Summary: Myocardial infarction (MI) is a leading cause of global deaths. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), have been found to regulate pathological processes in MI, and exosomal ncRNAs have been shown to play important roles in cell communication and disease development. Therefore, understanding the role of ncRNAs and exosomal ncRNAs in MI is of great significance for diagnosis and prognosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Samarth Kansara, Agrata Singh, Abhishesh Kumar Badal, Reshma Rani, Prakash Baligar, Manoj Garg, Amit Kumar Pandey
Summary: Altered energy metabolism is a key characteristic of tumorigenesis, and non-coding RNAs (ncRNAs) play a significant role in regulating glucose metabolism in human cancers. In this review, the aberrant expression of glucose metabolic pathways in breast cancer is outlined, and the potential applications of ncRNAs in regulating energy pathways, as well as their importance in prognosis, diagnosis, and future therapeutics for breast carcinoma, are discussed.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Jia-Li Shao, Li-Juan Wang, Ji Xiao, Jin-Feng Yang
Summary: Hepatic ischemia-reperfusion injury (HIRI) is a major complication of liver surgery and transplantation, with significant impact on postoperative outcomes. The underlying mechanisms involve oxidative stress, inflammatory responses, immunoreactions, and cell death. Non-coding RNAs (ncRNAs) have emerged as important players in HIRI, with differential expression and involvement in pathological processes. Some ncRNAs have been identified as biomarkers for early diagnosis and assessment of liver damage severity, as well as potential therapeutic targets for attenuating HIRI. However, further studies are needed to fully understand the therapeutic potential and feasibility of clinical application.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cell Biology
Lijie Wang, Lu Wang, Qi Wang
Summary: The study showed that NEAT1 sponging with miR-22-3p affects MI in CHD by competitively binding to miR-22-3p and positively regulating Ltb4r1 expression. Silencing NEAT1 or downregulating Ltb4r1 expression improved cardiac function, reduced infarct size, and decreased levels of inflammatory markers. This indicates that the NEAT1/miR-22-3p/Ltb4r1 signaling pathway may be a useful target for personalized treatments for MI.
Article
Cell Biology
Jing Zhao, Linlin Yin, Lin Jiang, Li Hou, Ling He, Chunyan Zhang
Summary: The study revealed the essential role of PTEN nuclear translocation in neuronal injury following oxygen-glucose deprivation in rat cortical neurons. The mechanism may involve modulation of cell signaling pathways and apoptosis-related proteins. Preventing PTEN nuclear translocation could be a potential strategy for preventing brain injury following hypoxia-ischemia.
Article
Biochemistry & Molecular Biology
Javad Amini, Cordian Beyer, Adib Zendedel, Nima Sanadgol
Summary: Anxiety-related disorders are chronic neuropsychological diseases and a leading cause of disability. Dysregulation of microRNAs (miRs) is observed in the pathological course of these disorders. This study identified anxiolytic and anxiogenic miRs that target specific genes and cellular pathways, primarily the MAPK signaling pathway. The findings suggest that miR-34c, Let-7d, miR-17, miR-19b, miR-92a, and miR-218 are important modulators in anxiety pathophysiology. Further investigation is needed to explore the potential role of E2F5 as a target for anxiolytic miRNAs in anxiety-related disorders.
Review
Biochemistry & Molecular Biology
Bianca Oana Pirlog, Silvina Ilut, Radu Pirlog, Paul Chiroi, Andreea Nutu, Delia Ioana Radutiu, George Daniel Cuc, Ioana Berindan-Neagoe, Seyed Fazel Nabavi, Rosanna Filosa, Seyed Mohammad Nabavi
Summary: This study aims to provide an integrated image of the DDR pathway in glioblastoma, with a focus on the regulatory roles of ncRNAs. DDR inhibitors, specifically PARP inhibitors, are emerging as an important new therapeutic approach for tumors with genomic instability and alterations in DDR pathways. The first clinical trials with PARPi in GBM are currently ongoing.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jing Yan, Zehua Li, Yu Liang, Chaobo Yang, Wen Ou, Huaqiang Mo, Min Tang, Deshu Chen, Chongbin Zhong, Dongdong Que, Liyun Feng, Hua Xiao, Xudong Song, Pingzhen Yang
Summary: This study demonstrates that fucoxanthin (FX) alleviates myocardial ischemia and reperfusion injury (MIRI) through the inhibition of ferroptosis via the NRF2 signaling pathway.
Review
Cell Biology
Luhan Xie, Qingqing Zhang, Jun Mao, Jun Zhang, Lianhong Li
Summary: Recent studies have shown that lncRNAs are dynamically expressed in cardiovascular diseases and play a crucial role in heart development and myocardial infarction. They are highlighted for their potential as novel diagnostic biomarkers and therapeutic targets for myocardial infarction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
M. M. Kaczmarek, Z. P. Reliszko, J. Szuszkiewicz, A. Nitkiewicz, M. M. Guzewska, K. Myszczynski, M. Romaniewicz, M. Sikora, M. Kajko, Y. Heifetz
Summary: Circulating miRNAs serve as potential indicators of reproductive status in pigs, with distinct profiles found in serum samples collected from cyclic and pregnant animals. The study identified reproductive status-dependent miRNAs involved in processes important during the estrous cycle and early pregnancy, highlighting their potential as biomarkers for reproductive health and breeding management.
Article
Genetics & Heredity
Christopher Wong, Pratik S. Kadekar, Elena S. Jurczak, Richard S. Roy
Summary: During environmental challenges, organisms can temporarily halt reproduction and enter a diapause stage. In C. elegans, the activation of AMPK in neurons plays a critical role in controlling germ cell development quiescence during the dauer stage. Genetic analysis revealed that AMPK activation in neurons leads to changes in RAB-7 trafficking through the regulation of TBC-7, a predicted RabGAP protein. This cellular trafficking pathway, regulated by AMPK and microRNAs, controls germline gene expression cell non-autonomously in response to adverse environmental conditions.
Article
Medicine, Research & Experimental
Kunsheng Li, Pengyu Zhou, Jie Li, Yongqing Cheng, Shiliang Li, Yumeng Wang, Weipeng Jiang, Yang Bai, Hailong Cao, Dongjin Wang
Summary: The expression and function of P2Y14 receptor in neutrophils after myocardial infarction/reperfusion (MIR) injury were investigated. The results showed that P2Y14 receptor is involved in the regulation of inflammation in the infarct area after MIR, and it establishes a novel signaling pathway concerning the interplay between cardiomyocytes and neutrophils in the heart tissue.
Review
Cardiac & Cardiovascular Systems
Fuwen Huang, Jingting Mai, Jingwei Chen, Yinying He, Xiaojun Chen
Summary: This article explores the regulation of non-coding RNAs on autophagy in myocardial ischemia-reperfusion injury and highlights their importance in disease progression, contributing to research and development in the treatment of cardiovascular diseases.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Article
Engineering, Biomedical
Ziyu Yu, Yuwen Wen, Nan Jiang, Zhidong Li, Jieying Guan, Yingying Zhang, Caibing Deng, Ling Zhao, Song Guo Zheng, Yingting Zhu, Wenru Su, Yehong Zhuo
Summary: This study investigates the potential therapeutic pathway for neuroprotection against retinal ischemia-reperfusion injury (IRI) using gingival mesenchymal stem cell (GMSC) exosomes stimulated by TNF-alpha. The results suggest that TG-exos can alleviate inflammation and cell loss in the IRI mouse model. Furthermore, miR-21-5p enriched in TG-exos plays a crucial role in neuroprotection and anti-inflammation by targeting the MEG3/miR-21-5p/PDCD4 axis.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)