Reinventing clinical trials

Fresh from the biologic pipeline—2010

(2011) Jim Kling   NATURE BIOTECHNOLOGY

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

The BATTLE Trial: Personalizing Therapy for Lung Cancer

(2011) Edward S. Kim et al.   Cancer Discovery

Biomarker-led adaptive trial blazes a trail in breast cancer

(2010) Malorye Allison   NATURE BIOTECHNOLOGY

Biomarkers on a roll

(2010)   NATURE BIOTECHNOLOGY

The HER2 testing conundrum

(2010) Malorye Allison   NATURE BIOTECHNOLOGY

2009 FDA drug approvals

(2010) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

Placebos without Deception: A Randomized Controlled Trial in Irritable Bowel Syndrome

(2010) Ted J. Kaptchuk et al.   PLoS One

Utility of Adiponectin as a Biomarker Predictive of Glycemic Efficacy Is Demonstrated by Collaborative Pooling of Data From Clinical Trials Conducted by Multiple Sponsors

(2009) J A Wagner et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Spending on new drug development

(2009) Christopher Paul Adams et al.   HEALTH ECONOMICS

The Use of Electronic Data Capture Tools in Clinical Trials: Web-Survey of 259 Canadian Trials

(2009) Khaled El Emam et al.   JOURNAL OF MEDICAL INTERNET RESEARCH

Publication of Clinical Trials Supporting Successful New Drug Applications: A Literature Analysis

(2008) Kirby Lee et al.   PLOS MEDICINE

Trends in the globalization of clinical trials

(2007) Fabio A. Thiers et al.   NATURE REVIEWS DRUG DISCOVERY