Multi-input Drug-Controlled Switches of Mammalian Gene Expression Based on Engineered Nuclear Hormone Receptors

MIRELLA: a mathematical model explains the effect of microRNA-mediated synthetic genes regulation on intracellular resource allocation

(2023) Federica Cella et al.   NUCLEIC ACIDS RESEARCH

Enhanced safety and efficacy of protease-regulated CAR-T cell receptors

(2022) Louai Labanieh et al.   CELL

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

Search and sequence analysis tools services from EMBL-EBI in 2022

(2022) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Advances in the Computational Design of Small-Molecule-Controlled Protein-Based Circuits for Synthetic Biology

(2022) Simon Kretschmer et al.   PROCEEDINGS OF THE IEEE

High-performance multiplex drug-gated CAR circuits

(2022) Hui-Shan Li et al.   CANCER CELL

Small molecule-inducible gene regulatory systems in mammalian cells: progress and design principles

(2022) Menna Siddiqui et al.   CURRENT OPINION IN BIOTECHNOLOGY

Multidimensional control of therapeutic human cell function with synthetic gene circuits

(2022) Hui-Shan Li et al.   SCIENCE

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

(2021) Max Jan et al.   Science Translational Medicine

Model-guided design of mammalian genetic programs

(2021) J. J. Muldoon et al.   Science Advances

Programmable protein circuit design

(2021) Zibo Chen et al.   CELL

Pharmacologic Control of CAR T Cells

(2021) Benjamin Caulier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells

(2021) Maysam Mansouri et al.   Protein & Cell

The COMET toolkit for composing customizable genetic programs in mammalian cells

(2020) Patrick S. Donahue et al.   Nature Communications

Macromolecular modeling and design in Rosetta: recent methods and frameworks

(2020) Julia Koehler Leman et al.   NATURE METHODS

Ligand-Induced Degradation of a CAR Permits Reversible Remote Control of CAR T Cell Activity In Vitro and In Vivo

(2020) Sarah A. Richman et al.   MOLECULAR THERAPY

A conformation-specific ON-switch for controlling CAR T cells with an orally available drug

(2020) Charlotte U. Zajc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization and mitigation of gene expression burden in mammalian cells

(2020) Timothy Frei et al.   Nature Communications

A modular degron library for synthetic circuits in mammalian cells

(2019) Hélène Chassin et al.   Nature Communications

Multi-input chemical control of protein dimerization for programming graded cellular responses

(2019) Glenna Wink Foight et al.   NATURE BIOTECHNOLOGY

An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics

(2019) Molly E. Allen et al.   ACS Synthetic Biology

StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins

(2018) Conor L. Jacobs et al.   NATURE METHODS

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Programming gene and engineered-cell therapies with synthetic biology

(2018) Tasuku Kitada et al.   SCIENCE

Programming CAR-T cells to kill cancer

(2018) Louai Labanieh et al.   Nature Biomedical Engineering

The nuclear receptor superfamily: A structural perspective

(2018) Emily R. Weikum et al.   PROTEIN SCIENCE

Predicting Transcriptional Output of Synthetic Multi-input Promoters

(2018) David M. Zong et al.   ACS Synthetic Biology

HIT-Cas9: a CRISPR/Cas9 Genome Editing Device Under Tight and Effective Drug Control.

(2018) Chen Zhao et al.   Molecular Therapy-Nucleic Acids

A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila

(2018) Naoki Okamoto et al.   DEVELOPMENTAL CELL

Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells

(2017) Benjamin H Weinberg et al.   NATURE BIOTECHNOLOGY

Human antibody-based chemically induced dimerizers for cell therapeutic applications

(2017) Zachary B Hill et al.   Nature Chemical Biology

Chimeric antigen receptor T-cell therapy — assessment and management of toxicities

(2017) Sattva S. Neelapu et al.   Nature Reviews Clinical Oncology

An Orthogonal Multi-input Integration System to Control Gene Expression in Escherichia coli

(2017) Fabio Annunziata et al.   ACS Synthetic Biology

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

A Tet-On Inducible System for Controlling CD19-Chimeric Antigen Receptor Expression upon Drug Administration

(2016) R. Sakemura et al.   Cancer Immunology Research

An Inducible Caspase-9 Suicide Gene to Improve the Safety of Therapy Using Human Induced Pluripotent Stem Cells

(2015) Shigeki Yagyu et al.   MOLECULAR THERAPY

A split-Cas9 architecture for inducible genome editing and transcription modulation

(2015) Bernd Zetsche et al.   NATURE BIOTECHNOLOGY

Highly efficient Cas9-mediated transcriptional programming

(2015) Alejandro Chavez et al.   NATURE METHODS

Remote control of therapeutic T cells through a small molecule-gated chimeric receptor

(2015) C.-Y. Wu et al.   SCIENCE

Spatial and Temporal Control of Transgene Expression in Zebrafish

(2014) Alexander A. Akerberg et al.   PLoS One

Modular, Multi-Input Transcriptional Logic Gating with Orthogonal LacI/GalR Family Chimeras

(2014) David L. Shis et al.   ACS Synthetic Biology

Synthetic analog computation in living cells

(2013) Ramiz Daniel et al.   NATURE

Rapid and orthogonal logic gating with a gibberellin-induced dimerization system

(2012) Takafumi Miyamoto et al.   Nature Chemical Biology

Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription

(2010) K Tóth et al.   CELL DEATH AND DIFFERENTIATION