Contribution of HIF-1α/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury

Irinotecan-induced NASH and liver failure

(2021) Murat Araz et al.   Clinics and Research in Hepatology and Gastroenterology

Hypoxia-inducible factor-2 promotes liver fibrosis in non-alcoholic steatohepatitis liver disease via the NF-κB signalling pathway

(2021) Hao Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The ménage à trois of autophagy, lipid droplets and liver disease

(2021) Yasmina Filali-Mouncef et al.   Autophagy

Structures and functions of the inflammasome engine

(2021) Longfei Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice

(2021) Thuy T.P. Nguyen et al.   MOLECULAR CELL

HIF-1α Activation Promotes Luteolysis by Enhancing ROS Levels in the Corpus Luteum of Pseudopregnant Rats

(2021) Zonghao Tang et al.   Oxidative Medicine and Cellular Longevity

Irinotecan-Induced Steatohepatitis: Current Insights

(2021) Jun Han et al.   Frontiers in Oncology

Chemotherapy-associated steatohepatitis

(2020) Lucy Meunier et al.   Annals of Hepatology

Protective effect of Berberine on reproductive function and spermatogenesis in diabetic rats via inhibition of ROS/JAK2/NFκB pathway

(2020) Jingyu Song et al.   Andrology

AST/ALT ratio as a significant predictor of the incidence risk of prostate cancer

(2020) Jiatong Zhou et al.   Cancer Medicine

Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis

(2020) Da-Hye Lee et al.   Autophagy

Silencing HIF-1α aggravates non-alcoholic fatty liver disease in vitro through inhibiting PPAR-α/ANGPTL4 singling pathway

(2020) Yan He et al.   Gastroenterologia y Hepatologia

Hypoxia and Non-alcoholic Fatty Liver Disease

(2020) Stephania C. Isaza et al.   Frontiers in Medicine

Paeonol derivative-6 attenuates inflammation by activating ZEB2 in acute liver injury

(2020) Junfa Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

HIF-1α protects against oxidative stress by directly targeting mitochondria

(2019) Hong-Sheng Li et al.   Redox Biology

Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK/mTOR pathway

(2019) Congjian Shi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hypoxia exacerbates nonalcoholic fatty liver disease via the HIF-2α/PPARα pathway

(2019) Jiandi Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Pharmacokinetic and pharmacogenetic markers of irinotecan toxicity

(2018) Roberta Zilles Hahn et al.   CURRENT MEDICINAL CHEMISTRY

Protective effects of α-mangostin against acetaminophen-induced acute liver injury in mice

(2018) Tianhua Fu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Intestinal HIF-1α deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction

(2018) Tuo Shao et al.   JOURNAL OF HEPATOLOGY

Macrophage-specific HIF-1α contributes to impaired autophagic flux in non-alcoholic steatohepatitis

(2018) Xiaojing Wang et al.   HEPATOLOGY

Pharmacometabolomics Reveals Irinotecan Mechanism of Action in Cancer Patients

(2018) Xun Bao et al.   JOURNAL OF CLINICAL PHARMACOLOGY

HIF-1α/Beclin1-Mediated Autophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning

(2018) Na Lu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis

(2017) Abdo Mahli et al.   GUT

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia

(2017) Neha Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan

(2017) Eudmar Marcolino Assis-Júnior et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver resection for cancer: New developments in prediction, prevention and management of postresectional liver failure

(2016) Kim M.C. van Mierlo et al.   JOURNAL OF HEPATOLOGY

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Autophagy and Lipid Droplets in the Liver

(2015) Nuria Martinez-Lopez et al.   Annual Review of Nutrition

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

Autophagy and apoptosis in liver injury

(2015) Kewei Wang   CELL CYCLE

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway

(2014) S. Zhu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Chemotherapy-associated steatohepatitis induced by irinotecan: a novel animal model

(2014) Marcelo Leite Vieira Costa et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis

(2014) Timea Csak et al.   LIVER INTERNATIONAL

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

Complete Activation of Autophagic Process Attenuates Liver Injury and Improves Survival in Septic Mice

(2013) Chih-Wen Lin et al.   SHOCK

Prediction, prevention and management of postresection liver failure

(2011) J. S. Hammond et al.   BRITISH JOURNAL OF SURGERY

Hepatocyte-specific hypoxia-inducible factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice

(2011) Bharath Nath et al.   HEPATOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE