CCL2 is required for initiation but not persistence of HIV infection mediated neurocognitive disease in mice

The anti-inflammatory agent bindarit attenuates the impairment of neural development through suppression of microglial activation in a neonatal hydrocephalus mouse model

(2022) Eri Iwasawa et al.   JOURNAL OF NEUROSCIENCE

Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

(2022) Xiaolei Zhu et al.   NEUROBIOLOGY OF DISEASE

Buprenorphine reverses neurocognitive impairment in EcoHIV infected mice: A potential therapy for HIV-NCI

(2022) Aniella J. Murphy et al.   Frontiers in Immunology

Microglial HIV-1 Expression: Role in HIV-1 Associated Neurocognitive Disorders

(2021) Hailong Li et al.   Viruses-Basel

Central Nervous System (CNS) Viral Seeding by Mature Monocytes and Potential Therapies To Reduce CNS Viral Reservoirs in the cART Era

(2021) Rosiris León-Rivera et al.   mBio

Interrogating the impact of combination antiretroviral therapies on HIV‐associated neurocognitive disorders

(2021) Ishta Sharma   HIV MEDICINE

Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats

(2021) Farshid Etaee et al.   Frontiers in Behavioral Neuroscience

Suppression of microglial activation and monocyte infiltration ameliorates cerebellar hemorrhage induced-brain injury and ataxia

(2020) Shu-Tao Xie et al.   BRAIN BEHAVIOR AND IMMUNITY

Treatment with buprenorphine prior to EcoHIV infection of mice prevents the development of neurocognitive impairment

(2020) Matias Jaureguiberry‐Bravo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HAND in EcoHIV-infected mice

(2019) Boe-Hyun Kim et al.   AIDS

Pathogenesis of age-related HIV neurodegeneration

(2019) Miroslaw Mackiewicz et al.   JOURNAL OF NEUROVIROLOGY

Glutamine Antagonist JHU083 Normalizes Aberrant Glutamate Production and Cognitive Deficits in the EcoHIV Murine Model of HIV-Associated Neurocognitive Disorders

(2019) Michael T. Nedelcovych et al.   Journal of Neuroimmune Pharmacology

Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment

(2019) Jennifer Kelschenbach et al.   mBio

Targeting the HIV-infected brain to improve ischemic stroke outcome

(2019) Luc Bertrand et al.   Nature Communications

Nef-induced CCL2 Expression Contributes to HIV/SIV Brain Invasion and Neuronal Dysfunction

(2019) Michael H. Lehmann et al.   Frontiers in Immunology

Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice

(2018) Katherine E. Olson et al.   JOURNAL OF NEUROVIROLOGY

Resistance of HIV-infected macrophages to CD8+ T lymphocyte–mediated killing drives activation of the immune system

(2018) Kiera L. Clayton et al.   NATURE IMMUNOLOGY

EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment

(2018) Chao-Jiang Gu et al.   PLoS Pathogens

Methamphetamine increases HIV infectivity in neural progenitor cells

(2017) Marta Skowronska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frontline Science: CXCR7 mediates CD14 + CD16 + monocyte transmigration across the blood brain barrier: a potential therapeutic target for NeuroAIDS

(2017) Mike Veenstra et al.   JOURNAL OF LEUKOCYTE BIOLOGY

N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders

(2017) Michael T. Nedelcovych et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms of CNS Viral Seeding by HIV + CD14 + CD16 + Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated Neurocognitive Disorders

(2017) Mike Veenstra et al.   mBio

HIV Alters Gap Junction-Mediated Intercellular Communication in Human Brain Pericytes

(2017) Hyung Joon Cho et al.   Frontiers in Molecular Neuroscience

Effect of ageing on neurocognitive function by stage of HIV infection: evidence from the Multicenter AIDS Cohort Study

(2017) Karl Goodkin et al.   Lancet HIV

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

Antidepressant-like Effects of Buprenorphine are Mediated by Kappa Opioid Receptors

(2016) Edgardo Falcon et al.   NEUROPSYCHOPHARMACOLOGY

Modeling HIV-1 Induced Neuroinflammation in Mice: Role of Platelets in Mediating Blood-Brain Barrier Dysfunction

(2016) Letitia D. Jones et al.   PLoS One

Identifying Neurocognitive Decline at 36 Months among HIV-Positive Participants in the CHARTER Cohort Using Group-Based Trajectory Analysis

(2016) Marie-Josée Brouillette et al.   PLoS One

Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis

(2016) Daniela Siegmund et al.   Cell Death & Disease

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

(2016) Claudia Pösel et al.   Jove-Journal of Visualized Experiments

The role of chemokine C-C motif ligand 2 genotype and cerebrospinal fluid chemokine C-C motif ligand 2 in neurocognition among HIV-infected patients

(2015) April D. Thames et al.   AIDS

The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy?

(2015) Daniela Angela Covino et al.   CURRENT DRUG TARGETS

Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection

(2015) Susana V. Bardina et al.   JOURNAL OF IMMUNOLOGY

Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation

(2015) Michela Sabbatucci et al.   Retrovirology

Neuropathology of HAND With Suppressive Antiretroviral Therapy: Encephalitis and Neurodegeneration Reconsidered

(2015) Benjamin B. Gelman   Current HIV/AIDS Reports

Systemic Effects of Inflammation on Health during Chronic HIV Infection

(2013) Steven G. Deeks et al.   IMMUNITY

Enhanced Human Immunodeficiency Virus Type 1 Expression and Neuropathogenesis in Knockout Mice Lacking Type I Interferon Responses

(2013) Hongxia He et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The end of AIDS: HIV infection as a chronic disease

(2013) Steven G Deeks et al.   LANCET

Mechanisms of HIV Entry into the CNS: Increased Sensitivity of HIV Infected CD14+CD16+ Monocytes to CCL2 and Key Roles of CCR2, JAM-A, and ALCAM in Diapedesis

(2013) Dionna W. Williams et al.   PLoS One

Bindarit

(2012) Eugenio Mora et al.   CELL CYCLE

Central Nervous System Viral Invasion and Inflammation During Acute HIV Infection

(2012) Victor Valcour et al.   JOURNAL OF INFECTIOUS DISEASES

The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis

(2012) Shujun Ge et al.   Journal of Neuroinflammation

Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment

(2011) Jarek Harezlak et al.   AIDS

Mice Chronically Infected with Chimeric HIV Resist Peripheral and Brain Superinfection: A Model of Protective Immunity to HIV

(2011) Jennifer L. Kelschenbach et al.   Journal of Neuroimmune Pharmacology

Astrocytes contacting HIV-1-infected macrophages increase the release of CCL2 in response to the HIV-1-dependent enhancement of membrane-associated TNFα in macrophages

(2010) Claudia Muratori et al.   GLIA

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 neuroimmunity in the era of antiretroviral therapy

(2010) Stephanie D. Kraft-Terry et al.   NEUROBIOLOGY OF DISEASE

The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice

(2009) G. Grassia et al.   CARDIOVASCULAR RESEARCH

Coordinated Regulation of SIV Replication and Immune Responses in the CNS

(2009) Kenneth W. Witwer et al.   PLoS One

Roles of MCP-1 in development of HIV-dementia

(2008) Navneet Kaur Dhillon   Frontiers in Bioscience-Landmark

Physiological properties of astroglial cell lines derived from mice with high (SAMP8) and low (SAMR1, ICR) levels of endogenous retrovirus

(2008) Boe-Hyun Kim et al.   Retrovirology