T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

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Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

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Multiparametric MRI for early identification of therapeutic response in recurrent glioblastoma treated with immune checkpoint inhibitors

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Nanoparticles Presenting Potent TLR7/8 Agonists Enhance Anti-PD-L1 Immunotherapy in Cancer Treatment

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Immunocytokines are a promising immunotherapeutic approach against glioblastoma

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Unique challenges for glioblastoma immunotherapy - Discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology

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Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal

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Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma

(2019) Junfei Zhao et al.   NATURE MEDICINE

Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma

(2019) Timothy F. Cloughesy et al.   NATURE MEDICINE

Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles

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Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases

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TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Developments in Blood-Brain Barrier Penetrance and Drug Repurposing for Improved Treatment of Glioblastoma

(2018) Bryan G. Harder et al.   Frontiers in Oncology

A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells

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Radiomic subtyping improves disease stratification beyond key molecular, clinical, and standard imaging characteristics in patients with glioblastoma

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The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome

(2017) Carlene Petes et al.   Frontiers in Immunology

Phagocytosis: An Immunobiologic Process

(2016) Siamon Gordon   IMMUNITY

Ferumoxytol nanoparticle uptake in brain during acute neuroinflammation is cell-specific

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In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis

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A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice

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Reprogramming of TLR7 signaling enhances antitumor NK and cytotoxic T cell responses

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A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia

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The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity

(2015) Zaida G Ramirez-Ortiz et al.   NATURE IMMUNOLOGY

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

(2015) Miles A. Miller et al.   Science Translational Medicine

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(2015) Max Kuhn   Journal of Statistical Software

A novel systemically administered toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models

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TLR Ligands in the Local Treatment of Established Intracerebral Murine Gliomas

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Analysis of the Neuroinflammatory Response to TLR7 Stimulation in the Brain: Comparison of Multiple TLR7 and/or TLR8 Agonists

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Recent advances in the role of toll-like receptors and TLR agonists in immunotherapy for human glioma

(2014) Shuanglin Deng et al.   Protein & Cell

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY