Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps

CXCR2 inhibition enables NASH-HCC immunotherapy

(2022) Jack Leslie et al.   GUT

CXCR2 inhibition in NASH-HCC

(2022) Eleni Kotsiliti   Nature Reviews Gastroenterology & Hepatology

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

(2021) Yansen Xiao et al.   CANCER CELL

Fibrotic enzymes modulate wound‐induced skin tumorigenesis

(2021) Lisette Van Hove et al.   EMBO REPORTS

Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen

(2021) Federico Uliana et al.   Nature Communications

Regulatory T cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis

(2021) Han Wang et al.   JOURNAL OF HEPATOLOGY

Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells

(2021) Sho Hangai et al.   NATURE IMMUNOLOGY

Neutrophils in cancer carcinogenesis and metastasis

(2021) Shumin Xiong et al.   Journal of Hematology & Oncology

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

(2021) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

(2020) David J. Clark et al.   CELL

p53, cancer and the immune response

(2020) Julianna Blagih et al.   JOURNAL OF CELL SCIENCE

Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response

(2020) Lu-Yu Yang et al.   Journal of Hematology & Oncology

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

(2020) Álvaro Teijeira et al.   IMMUNITY

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

(2020) Linbin Yang et al.   NATURE

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

(2020) Maria Teresa Masucci et al.   Frontiers in Immunology

Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing

(2019) Veronika Butin-Israeli et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

(2019) Ying Jiang et al.   NATURE

Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes

(2019) Ruidong Xue et al.   CANCER CELL

Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities

(2019) Suhas Vasaikar et al.   CELL

The liver as an endocrine organ - linking NAFLD and insulin resistance

(2019) Matthew J Watt et al.   ENDOCRINE REVIEWS

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors

(2019) Andrea Ponzetta et al.   CELL

Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth

(2019) Hamza O Yazdani et al.   CANCER RESEARCH

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

(2019) Qiang Gao et al.   CELL

Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

(2019) Atul S. Deshmukh et al.   Cell Metabolism

Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils

(2019) Karim Mahiddine et al.   JOURNAL OF CLINICAL INVESTIGATION

A comprehensive review of signal peptides: Structure, roles, and applications

(2018) Hajar Owji et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

TRPM2 modulates neutrophil attraction to murine tumor cells by regulating CXCL2 expression

(2018) Maya Gershkovitz et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors

(2018) Zhuo Cheng et al.   CELL RESEARCH

Neutrophil extracellular traps induced by IL-8 promote diffuse large B cell lymphoma progression via the TLR9 signaling

(2018) Man Nie et al.   CLINICAL CANCER RESEARCH

Proteomic profiling of the cancer cell secretome: informing clinical research

(2017) Yung-Chin Hsiao et al.   Expert Review of Proteomics

Neutrophils in Homeostasis, Immunity, and Cancer

(2017) José Ángel Nicolás-Ávila et al.   IMMUNITY

The proprotein convertase furin in tumour progression

(2017) Patricia Jaaks et al.   INTERNATIONAL JOURNAL OF CANCER

IL-36α Regulates Tubulointerstitial Inflammation in the Mouse Kidney

(2017) Osamu Ichii et al.   Frontiers in Immunology

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

(2016) Sunil Singhal et al.   CANCER CELL

Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

(2016) Shao-Lai Zhou et al.   GASTROENTEROLOGY

CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer

(2016) H Zhang et al.   ONCOGENE

Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells

(2015) Adam Blaisdell et al.   CANCER CELL

A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis

(2015) Shuying Shen et al.   CELL RESEARCH

MET is required for the recruitment of anti-tumoural neutrophils

(2015) Veronica Finisguerra et al.   NATURE

Correlation of cumulus gene expression of GJA1, PRSS35, PTX3, and SERPINE2 with oocyte maturation, fertilization, and embryo development

(2015) Sheng-Hsiang Li et al.   Reproductive Biology and Endocrinology

L-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

(2014) M. Fletcher et al.   CANCER RESEARCH

Hepatocyte nuclear factor 4α-nuclear factor-κB feedback circuit modulates liver cancer progression

(2014) Bei-Fang Ning et al.   HEPATOLOGY

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

(2014) Evgeniy B. Eruslanov et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

(2013) K. De Filippo et al.   BLOOD

Distinct Spatiotemporal Expression of Serine Proteases Prss23 and Prss35 in Periimplantation Mouse Uterus and Dispensable Function of Prss35 in Fertility

(2013) Honglu Diao et al.   PLoS One

On the cytokines produced by human neutrophils in tumors

(2013) Cristina Tecchio et al.   SEMINARS IN CANCER BIOLOGY

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Toxoplasma gondii Triggers Release of Human and Mouse Neutrophil Extracellular Traps

(2011) Delbert S. Abi Abdallah et al.   INFECTION AND IMMUNITY

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

(2010) M. Kowanetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Genotoxic effects of neutrophils and hypochlorous acid

(2009) N. Gungor et al.   MUTAGENESIS

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Improved visualization of protein consensus sequences by iceLogo

(2009) Niklaas Colaert et al.   NATURE METHODS

Astrocyte Elevated Gene-1 is a Novel Prognostic Marker for Breast Cancer Progression and Overall Patient Survival

(2008) J. Li et al.   CLINICAL CANCER RESEARCH

Expression and Localization of the Serine Proteases High-Temperature Requirement Factor A1, Serine Protease 23, and Serine Protease 35 in the Mouse Ovary

(2008) Patrik Wahlberg et al.   ENDOCRINOLOGY

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

(2008) F. Shojaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA