Development of a novel senolysis approach targeting the senescent fibroblast marker HTR2A via antibody-dependent cellular cytotoxicity.

Selective Elimination of Senescent Fibroblasts by Targeting the Cell Surface Protein ACKR3

(2022) Kento Takaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging

(2022) Kento Takaya et al.   GeroScience

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

(2021) Yoshikazu Johmura et al.   SCIENCE

Connective Tissue and Fibroblast Senescence in Skin Aging

(2021) Meinhard Wlaschek et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets

(2021) Martina Rossi et al.   Cells

Telomeres: beacons of autocrine and paracrine DNA damage during skin aging

(2020) Stella Victorelli et al.   CELL CYCLE

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Molecular Mechanisms of Dermal Aging and Antiaging Approaches

(2019) Jung-Won Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial

(2019) Christina Lee Chung et al.   GeroScience

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Region-specific regulation of the serotonin 2A receptor expression in development and ageing inpost mortemhuman brain

(2015) Zoya Marinova et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Multiple Regulatory Variants Modulate Expression of 5-Hydroxytryptamine 2A Receptors in Human Cortex

(2012) Ryan M. Smith et al.   BIOLOGICAL PSYCHIATRY

Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells

(2012) J Cahu et al.   Cell Death & Disease

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL