Electrochemical Difunctionalization of gem-Difluoroalkenes: A Metal-Free Synthesis of α-Difluoro(alkoxyl/azolated) Methylated Ethers

Difunctionalization of gem-Difluoroalkenes via Photoredox Catalysis: Synthesis of Diverse α,α-Difluoromethyl-β-alkoxysulfones

(2022) Wenjuan Zhu et al.   ORGANIC LETTERS

Cu(II)-Catalyzed Unsymmetrical Dioxidation of gem-Difluoroalkenes to Generate α,α-Difluorinated-α-phenoxyketones

(2022) Suvajit Koley et al.   JOURNAL OF ORGANIC CHEMISTRY

Electrochemical Benzylic C(sp3)–H Acyloxylation

(2022) Alexander P. Atkins et al.   ORGANIC LETTERS

Tunable alkoxy-nucleophilic addition under photochemical condition: Dioxidation of gem‑difluoroalkenes with O2

(2022) Yuanwei Liang et al.   Molecular Catalysis

Electrochemically time-dependent oxidative coupling/coupling-cyclization reaction between heterocycles: tunable synthesis of polycyclic indole derivatives with fluorescence properties

(2022) Zuozhou Ning et al.   Science China-Chemistry

Nickel-catalyzed switchable asymmetric electrochemical functionalization of alkenes

(2022) Kang Liang et al.   Science Advances

Acid-Catalyzed Hydrothiolation of gem-Difluorostyrenes to Access α,α-Difluoroalkylthioethers

(2021) Jacob P. Sorrentino et al.   JOURNAL OF ORGANIC CHEMISTRY

Solvent‐Switched Oxidation Selectivities with O2: Controlled Synthesis of α‐Difluoro(thio)methylated Alcohols and Ketones

(2021) Huanfeng Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd/Cu‐Catalyzed Defluorinative Carbonylative Coupling of Aryl Iodides and gem ‐Difluoroalkenes: Efficient Synthesis of α‐Fluorochalcones

(2021) Fu‐Peng Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

[3 + 2]-Annulation of gem-Difluoroalkenes and Pyridinium Ylides: Access to Functionalized 2-Fluoroindolizines

(2021) Jun-Qi Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Electrochemically Driven Radical Reactions: From Direct Electrolysis to Molecular Catalysis

(2021) Na Chen et al.   CHEMICAL RECORD

Late-stage azolation of benzylic C‒H bonds enabled by electrooxidation

(2021) Zhixiong Ruan et al.   Science China-Chemistry

The Renaissance of Electro‐Organic Synthesis for the Difunctionalization of Alkenes and Alkynes: A Sustainable Approach

(2021) Ditto Abraham Thadathil et al.   Asian Journal of Organic Chemistry

Recent Advances in the Synthesis of Difluorinated Architectures from Trifluoromethyl Groups

(2021) Feng Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Electrochemical oxidation-induced etherification via C(sp3)─H/O─H cross-coupling

(2020) Huamin Wang et al.   Science Advances

Palladium-Catalyzed Stereoselective Hydrodefluorination of Tetrasubstituted gem-Difluoroalkenes

(2020) Qiao Ma et al.   ORGANIC LETTERS

Site‐Selective Electrochemical Benzylic C–H Amination

(2020) Zhong-Wei Hou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chalcogenide-Catalyzed Intermolecular Electrophilic Thio- and Halofunctionalization of gem-Difluoroalkenes: Construction of Diverse Difluoroalkyl Sulfides and Halides

(2020) Quanbin Jiang et al.   ORGANIC LETTERS

Recent Advances on the Electrochemical Difunctionalization of Alkenes/Alkynes

(2019) Haibo Mei et al.   CHINESE JOURNAL OF CHEMISTRY

Photoredox-Coupled F-Nucleophilic Addition: Allylation of gem -Difluoroalkenes

(2019) Haidong Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Stereoselective Alkenylation of Allenoates with gem-Difluoroalkenes: Facile Access to Fluorinated 1,4-Enynes Bearing an All-Carbon Quaternary Center

(2019) Qi-Qi Zhang et al.   ORGANIC LETTERS

Selective Copper Complex-Catalyzed Hydrodefluorination of Fluoroalkenes and Allyl Fluorides: A Tale of Two Mechanisms

(2019) Nicholas O. Andrella et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrochemical Difunctionalization of Alkenes via Four-component Reactions Cascade Mumm Rearrangement: Rapid Access to Functionalized Imides

(2019) Peipei Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective Radical Hydroboration of gem-Difluoroalkenes: Synthesis of α-Borylated Organofluorines

(2019) Ji-Kang Jin et al.   ORGANIC LETTERS

Practical and stereoselective electrocatalytic 1,2-diamination of alkenes

(2019) Chen-Yan Cai et al.   Nature Communications

Recent Advances in Electrochemical Oxidative Cross‐Coupling of Alkenes with H 2 Evolution

(2019) Pan Wang et al.   ChemCatChem

Difluorocarbene as a Building Block for Consecutive Bond-Forming Reactions

(2018) Alexander D. Dilman et al.   ACCOUNTS OF CHEMICAL RESEARCH

Transition Metal-Mediated and -Catalyzed C-F Bond Activation via Fluorine Elimination

(2018) Takeshi Fujita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of α-CF3 and α-CF2H amines via the aminofluorination of fluorinated alkenes

(2018) Ling Yang et al.   CHEMICAL COMMUNICATIONS

Electrochemical strategies for C–H functionalization and C–N bond formation

(2018) Markus D. Kärkäs   CHEMICAL SOCIETY REVIEWS

An Electrocatalytic Approach to the Radical Difunctionalization of Alkenes

(2018) Gregory S. Sauer et al.   ACS Catalysis

Electrochemical Oxidative Cross-coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation

(2018) Shan Tang et al.   Chem

Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides

(2018) Zhang Feng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Base Catalysis Enables Access to α,α-Difluoroalkylthioethers

(2017) Douglas L. Orsi et al.   ORGANIC LETTERS

Silicon-Based Reagents for Difluoromethylation and Difluoromethylenation Reactions

(2017) G. Prakash et al.   SYNTHESIS-STUTTGART

Recent advances in the synthesis and CF functionalization of gem-difluoroalkenes

(2017) Xuxue Zhang et al.   TETRAHEDRON LETTERS

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in the Synthetic Application of Difluorocarbene

(2014) Jinbo Hu et al.   SYNTHESIS-STUTTGART

Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

(2013) Elizabeth A. Ilardi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Metal-Catalyzed Reactions of gem-Dihalovinyl Systems

(2011) Giorgio Chelucci   CHEMICAL REVIEWS

Organic fluorine compounds: a great opportunity for enhanced materials properties

(2011) Ricarda Berger et al.   CHEMICAL SOCIETY REVIEWS

Synthetic approaches to monofluoroalkenes

(2011) Grégory Landelle et al.   CHEMICAL SOCIETY REVIEWS