Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status

Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States

(2023) Kelly M. Montgomery et al.   Journal of the American Chemical Society

Classification of diseases with accumulation of Tau protein

(2022) Gabor G. Kovacs et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cryo-EM structures of amyloid-β 42 filaments from human brains

(2022) Yang Yang et al.   SCIENCE

Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases

(2022) Andrew Chang et al.   CELL

Tauopathies: new perspectives and challenges

(2022) Yi Zhang et al.   Molecular Neurodegeneration

Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition

(2022) Sushma Subedi et al.   MOLECULES

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

(2022) Romany Abskharon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly of recombinant tau into filaments identical to those of Alzheimer’s disease and chronic traumatic encephalopathy

(2022) Sofia Lövestam et al.   eLife

Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro

(2022) Paul M. Seidler et al.   Nature Communications

Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure

(2022) Xiang Li et al.   iScience

Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

(2021) Yang Shi et al.   ACTA NEUROPATHOLOGICA

Structure of Tau filaments in Prion protein amyloidoses

(2021) Grace I. Hallinan et al.   ACTA NEUROPATHOLOGICA

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies

(2021) Yuxing Xia et al.   Molecular Neurodegeneration

Cellular and pathological heterogeneity of primary tauopathies

(2021) Dah-eun Chloe Chung et al.   Molecular Neurodegeneration

Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU

(2021) Sarah Bachmann et al.   Frontiers in Neuroscience

Structure-based classification of tauopathies

(2021) Yang Shi et al.   NATURE

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

(2021) Z. Faidon Brotzakis et al.   ACS Central Science

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics

(2020) Varnavas D. Mouchlis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Crystal structure of the human tau PHF core domain VQIINK complexed with the Fab domain of monoclonal antibody Tau2r3

(2020) Tomohiro Tsuchida et al.   FEBS LETTERS

Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody

(2020) Kristof Van Kolen et al.   JOURNAL OF ALZHEIMERS DISEASE

Much More Than a Cytoskeletal Protein: Physiological and Pathological Functions of the Non-microtubule Binding Region of Tau

(2020) Roland Brandt et al.   Frontiers in Neurology

Characterization of tau binding by gosuranemab

(2020) Richelle Sopko et al.   NEUROBIOLOGY OF DISEASE

Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines

(2020) Catharine Shipps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

(2019) Benjamin Falcon et al.   NATURE

Structural characterization of monoclonal antibodies targeting C-terminal Ser404 region of phosphorylated tau protein

(2019) Jessica E. Chukwu et al.   mAbs

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

The Evolution of Tau Phosphorylation and Interactions

(2019) Nataliya I. Trushina et al.   Frontiers in Aging Neuroscience

Mechanisms of secretion and spreading of pathological tau protein

(2019) Cecilia A. Brunello et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure-based inhibitors halt prion-like seeding by Alzheimer's disease–and tauopathy–derived brain tissue samples

(2019) Paul Matthew Seidler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

(2018) Sebastian A. Andrei et al.   ACS Chemical Neuroscience

Tau filaments in neurodegenerative diseases

(2018) Michel Goedert   FEBS LETTERS

Annexins A2 and A6 interact with the extreme N terminus of tau and thereby contribute to tau's axonal localization

(2018) Anne Gauthier-Kemper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An N-terminal motif unique to primate tau enables differential protein–protein interactions

(2018) Kristie Stefanoska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Near-atomic model of microtubule-tau interactions

(2018) Elizabeth H. Kellogg et al.   SCIENCE

Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein

(2018) Jessica E. Chukwu et al.   Scientific Reports

A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities

(2018) Adrian Apetri et al.   Acta Neuropathologica Communications

Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau

(2018) Jeroen van Ameijde et al.   Acta Neuropathologica Communications

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Amyloidogenic cross-seeding of Tau protein: Transient emergence of structural variants of fibrils

(2018) Bartosz Nizynski et al.   PLoS One

New classification of tauopathies

(2018) G.U. Höglinger et al.   REVUE NEUROLOGIQUE

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

(2018) Benjamin Falcon et al.   ACTA NEUROPATHOLOGICA

Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody

(2018) Heng Zhang et al.   STRUCTURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Structure-based inhibitors of tau aggregation

(2017) P. M. Seidler et al.   Nature Chemistry

Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED

(2017) M Jason de la Cruz et al.   NATURE METHODS

Bacterial co-expression of human Tau protein with protein kinase A and 14-3-3 for studies of 14-3-3/phospho-Tau interaction

(2017) Kristina V. Tugaeva et al.   PLoS One

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau

(2017) Yunior Cabrales Fontela et al.   Nature Communications

Propagation of Tau aggregates

(2017) Michel Goedert et al.   Molecular Brain

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Primary Fibril Nucleation of Aggregation Prone Tau Fragments PHF6 and PHF6*

(2016) Florent X. Smit et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Presence of a carboxy-terminal pseudorepeat and disease-like pseudohyperphosphorylation critically influence tau’s interaction with microtubules in axon-like processes

(2016) Benedikt Niewidok et al.   MOLECULAR BIOLOGY OF THE CELL

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8

(2016) Thomas J. Malia et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Folding of the Tau Protein on Microtubules

(2015) Harindranath Kadavath et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stabilizer-Guided Inhibition of Protein-Protein Interactions

(2015) Lech-Gustav Milroy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau

(2015) Yuyoung Joo et al.   FASEB JOURNAL

VH-VL orientation prediction for antibody humanization candidate selection: A case study

(2015) Alexander Bujotzek et al.   mAbs

Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble

(2015) Shaolong Zhu et al.   PLoS One

Cell-based Models To Investigate Tau Aggregation

(2014) Sungsu Lim et al.   Computational and Structural Biotechnology Journal

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

(2013) Wendy Noble et al.   Frontiers in Neurology

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

Tau Isoform Composition Influences Rate and Extent of Filament Formation

(2012) Qi Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition

(2012) Heather H. Shih et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Out-of-register  -sheets suggest a pathway to toxic amyloid aggregates

(2012) C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards a Pharmacophore for Amyloid

(2011) Meytal Landau et al.   PLOS BIOLOGY

Molecular mechanisms for protein-encoded inheritance

(2009) Jed J W Wiltzius et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY