Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody

A walk through tau therapeutic strategies

(2019) Santosh Jadhav et al.   Acta Neuropathologica Communications

Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain

(2019) Jan R. Detrez et al.   NEUROBIOLOGY OF DISEASE

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody

(2019) Marie Albert et al.   BRAIN

Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial

(2019) Adam L Boxer et al.   LANCET NEUROLOGY

Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein

(2019) Luis Aragão Gomes et al.   ACTA NEUROPATHOLOGICA

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

An Overview on the Clinical Development of Tau-Based Therapeutics

(2018) Miguel Medina   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo

(2018) Marc Vandermeeren et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Kinetics in Neurons and the Human Central Nervous System

(2018) Chihiro Sato et al.   NEURON

Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis

(2018) Xiaopu Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease

(2018) Yan Zhou et al.   Frontiers in Aging Neuroscience

Inert and seed-competent tau monomers suggest structural origins of aggregation

(2018) Hilda Mirbaha et al.   eLife

Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

(2018) Jean-Philippe Courade et al.   ACTA NEUROPATHOLOGICA

Microtubule Depolymerization and Tau Phosphorylation

(2018) Félix Hernández et al.   JOURNAL OF ALZHEIMERS DISEASE

Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging

(2018) Qian Wu et al.   EBioMedicine

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atypical, non-standard functions of the microtubule associated Tau protein

(2017) Ioannis Sotiropoulos et al.   Acta Neuropathologica Communications

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

(2016) Bruno Vasconcelos et al.   ACTA NEUROPATHOLOGICA

Therapeutic strategies for the treatment of tauopathies: Hopes and challenges

(2016) Mansi R. Khanna et al.   Alzheimers & Dementia

High–Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo

(2016) Emilie Audouard et al.   AMERICAN JOURNAL OF PATHOLOGY

Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

(2016) Shuko Takeda et al.   ANNALS OF NEUROLOGY

Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes

(2016) Nicolas Renier et al.   CELL

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

(2016) S. J. Jackson et al.   JOURNAL OF NEUROSCIENCE

Structural diversity in a human antibody germline library

(2016) Alexey Teplyakov et al.   mAbs

Tau PET in Alzheimer disease and mild cognitive impairment

(2016) Hanna Cho et al.   NEUROLOGY

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8

(2016) Thomas J. Malia et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies

(2015) Jada Lewis et al.   ACTA NEUROPATHOLOGICA

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human secreted tau increases amyloid-beta production

(2015) Jessica Bright et al.   NEUROBIOLOGY OF AGING

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

(2015) Eve Peeraer et al.   NEUROBIOLOGY OF DISEASE

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

(2015) Maxime Derisbourg et al.   Scientific Reports

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease

(2014) Ludovic Collin et al.   BRAIN

Prion-like Mechanisms in the Pathogenesis of Tauopathies and Synucleinopathies

(2014) Michel Goedert et al.   Current Neurology and Neuroscience Reports

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyproline-II Helix in Proteins: Structure and Function

(2013) Alexei A. Adzhubei et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Human Framework Adaptation of a Mouse Anti-Human IL-13 Antibody

(2010) Johan Fransson et al.   JOURNAL OF MOLECULAR BIOLOGY

Tau-Focused Immunotherapy for Alzheimers Disease and Related Tauopathies

(2009) Einar Sigurdsson   Current Alzheimer Research

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY