Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau

A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities

(2018) Adrian Apetri et al.   Acta Neuropathologica Communications

Immunotherapy Targeting Pathological Tau Protein in Alzheimer's Disease and Related Tauopathies

(2017) Einar M. Sigurdsson   JOURNAL OF ALZHEIMERS DISEASE

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

(2016) Jing L. Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy

(2016) Erin E. Congdon et al.   Molecular Neurodegeneration

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8

(2016) Thomas J. Malia et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Native chemical ligation between asparagine and valine: Application and limitations for the synthesis of tri-phosphorylated C-terminal tau

(2015) Oliver Reimann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer’s Disease and Other Tauopathies

(2015) Sulana K. Schroeder et al.   Journal of Neuroimmune Pharmacology

VH-VL orientation prediction for antibody humanization candidate selection: A case study

(2015) Alexander Bujotzek et al.   mAbs

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

(2015) Eve Peeraer et al.   NEUROBIOLOGY OF DISEASE

Traceless Purification and Desulfurization of Tau Protein Ligation Products

(2014) Oliver Reimann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease

(2014) Ludovic Collin et al.   BRAIN

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo

(2013) Kiran Yanamandra et al.   NEURON

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

The Alzheimer’s Disease Related Tau Protein as a New Target for Chemical Protein Engineering

(2012) Malgorzata Broncel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Targeting Phospho-Ser422 by Active Tau Immunotherapy in the THYTau22 Mouse Model: A Suitable Therapeutic Approach

(2012) Nadege Zommer et al.   Current Alzheimer Research

A Generic Crystallization-like Model That Describes the Kinetics of Amyloid Fibril Formation

(2012) Rosa Crespo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice

(2011) Mian Bi et al.   PLoS One

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice

(2010) Moran Boimel et al.   EXPERIMENTAL NEUROLOGY

Tau-Focused Immunotherapy for Alzheimers Disease and Related Tauopathies

(2009) Einar Sigurdsson   Current Alzheimer Research

Tau as a biomarker of neurodegenerative diseases

(2008) Susanna Schraen-Maschke et al.   Biomarkers in Medicine

Genetically Altering Aβ Distribution from the Brain to the Vasculature Ameliorates Tau Pathology

(2008) Salvatore Oddo et al.   BRAIN PATHOLOGY