Human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerable

Acute IL-6 exposure triggers canonical IL6Ra signaling in hiPSC microglia, but not neural progenitor cells

(2023) Amalie C.M. Couch et al.   BRAIN BEHAVIOR AND IMMUNITY

Autism genes converge on asynchronous development of shared neuron classes

(2022) Bruna Paulsen et al.   NATURE

Virus-Induced Maternal Immune Activation as an Environmental Factor in the Etiology of Autism and Schizophrenia

(2022) Aïcha Massarali et al.   Frontiers in Neuroscience

Human organoids: New strategies and methods for analyzing human development and disease

(2022) Nina S. Corsini et al.   CELL

Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development

(2022) Zhuqing Xiong et al.   NATURE CELL BIOLOGY

A critical period of translational control during brain development at codon resolution

(2022) Dermot Harnett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases

(2021) Jonas Simon Fleck et al.   Cell Stem Cell

Molecular architecture of the developing mouse brain

(2021) Gioele La Manno et al.   NATURE

Single-cell Ribo-seq reveals cell cycle-dependent translational pausing

(2021) Michael VanInsberghe et al.   NATURE

A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies

(2021) Yunhee Kang et al.   NATURE NEUROSCIENCE

The Effects of Environmental Adversities on Human Neocortical Neurogenesis Modeled in Brain Organoids

(2021) Kseniia Sarieva et al.   Frontiers in Molecular Biosciences

Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring

(2021) Filippo Mirabella et al.   IMMUNITY

Dynamic changes in human single‐cell transcriptional signatures during fatal sepsis

(2021) Xinru Qiu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology

(2021) Chiara Tocco et al.   Frontiers in Molecular Neuroscience

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

(2021) Ilkka Fagerlund et al.   Cells

Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism

(2020) F. Kyle Satterstrom et al.   CELL

Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain

(2020) Yoshiaki Tanaka et al.   Cell Reports

Human organoids to model the developing human neocortex in health and disease

(2020) Shokoufeh Khakipoor et al.   BRAIN RESEARCH

COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex

(2020) Isabel Del Pino et al.   CEREBRAL CORTEX

NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients

(2020) Michele Bertacchi et al.   EMBO JOURNAL

Interferon-γ signaling in human iPSC–derived neurons recapitulates neurodevelopmental disorder phenotypes

(2020) Katherine Warre-Cornish et al.   Science Advances

Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation

(2020) Flavia S. Mueller et al.   MOLECULAR PSYCHIATRY

Maternal immune activation in mice disrupts proteostasis in the fetal brain

(2020) Brian T. Kalish et al.   NATURE NEUROSCIENCE

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

(2019) Simon T. Schafer et al.   NATURE NEUROSCIENCE

Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex

(2019) Simone Mayer et al.   NEURON

Single-cell genomics identifies cell type–specific molecular changes in autism

(2019) Dmitry Velmeshev et al.   SCIENCE

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Dynamics of cortical progenitors and production of subcerebral neurons are altered in embryos of a maternal inflammation model for autism

(2019) Lihi Ben-Reuven et al.   MOLECULAR PSYCHIATRY

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

Maternal Immune Activation During the Third Trimester Is Associated with Neonatal Functional Connectivity of the Salience Network and Fetal to Toddler Behavior

(2018) Marisa N. Spann et al.   JOURNAL OF NEUROSCIENCE

A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex

(2018) Suijuan Zhong et al.   NATURE

Maternal IL-6 during pregnancy can be estimated from newborn brain connectivity and predicts future working memory in offspring

(2018) Marc D. Rudolph et al.   NATURE NEUROSCIENCE

Maternal Interleukin-6 concentration during pregnancy is associated with variation in frontolimbic white matter and cognitive development in early life

(2018) Jerod M. Rasmussen et al.   NEUROIMAGE

Genetically engineered human cortical spheroid models of tuberous sclerosis

(2018) John D. Blair et al.   NATURE MEDICINE

Revealing the Critical Regulators of Cell Identity in the Mouse Cell Atlas

(2018) Shengbao Suo et al.   Cell Reports

What Is the Male-to-Female Ratio in Autism Spectrum Disorder? A Systematic Review and Meta-Analysis

(2017) Rachel Loomes et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development

(2017) A Kathuria et al.   MOLECULAR PSYCHIATRY

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder

(2017) M V Lombardo et al.   MOLECULAR PSYCHIATRY

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

(2017) Tomasz J. Nowakowski et al.   SCIENCE

Interleukin-6 Family Cytokines

(2017) Stefan Rose-John   Cold Spring Harbor Perspectives in Biology

Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder

(2017) Aditi Deshpande et al.   Cell Reports

Estimation of national, regional, and global prevalence of alcohol use during pregnancy and fetal alcohol syndrome: a systematic review and meta-analysis

(2017) Svetlana Popova et al.   Lancet Global Health

Fetal programming of neuropsychiatric disorders

(2016) Gavino Faa et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

(2016) G. B. Choi et al.   SCIENCE

Emerging Roles for the Unfolded Protein Response in the Developing Nervous System

(2016) Juliette D. Godin et al.   TRENDS IN NEUROSCIENCES

Maternal Immune Activation in Nonhuman Primates Alters Social Attention in Juvenile Offspring

(2015) Christopher J. Machado et al.   BIOLOGICAL PSYCHIATRY

Molecular Identity of Human Outer Radial Glia during Cortical Development

(2015) Alex A. Pollen et al.   CELL

Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles

(2015) Neele Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated fetal steroidogenic activity in autism

(2014) S Baron-Cohen et al.   MOLECULAR PSYCHIATRY

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

A High-Resolution Spatiotemporal Atlas of Gene Expression of the Developing Mouse Brain

(2014) Carol L. Thompson et al.   NEURON

Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson’s and other brain diseases

(2014) Carolina Cebrián et al.   Frontiers in Neuroanatomy

Transient p53 Suppression Increases Reprogramming of Human Fibroblasts without Affecting Apoptosis and DNA Damage

(2014) Mikkel A. Rasmussen et al.   Stem Cell Reports

MHCI Requires MEF2 Transcription Factors to Negatively Regulate Synapse Density during Development and in Disease

(2013) B. M. Elmer et al.   JOURNAL OF NEUROSCIENCE

Prenatal and postnatal hormone effects on the human brain and cognition

(2013) Bonnie Auyeung et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response

(2012) Devon B. Oskvig et al.   BRAIN BEHAVIOR AND IMMUNITY

Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism

(2012) Alan S. Brown   Developmental Neurobiology

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

(2011) Irina Voineagu et al.   NATURE

Neurogenic radial glia in the outer subventricular zone of human neocortex

(2010) David V. Hansen et al.   NATURE

OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling

(2010) Simone A Fietz et al.   NATURE NEUROSCIENCE

Maternal Smoking during Pregnancy and Regional Brain Volumes in Preterm Infants

(2009) Mikael Ekblad et al.   JOURNAL OF PEDIATRICS

Cytokines and CNS Development

(2009) Benjamin E. Deverman et al.   NEURON