Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion

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cBAF complex components and MYC cooperate early in CD8+ T cell fate

(2022) Ao Guo et al.   NATURE

SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma

(2022) Roodolph St. Pierre et al.   NATURE GENETICS

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

(2021) Nicole E. Scharping et al.   NATURE IMMUNOLOGY

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(2021) Min Zhou et al.   Oncogenesis

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Mammalian SWI/SNF continuously restores local accessibility to chromatin

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Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

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An orthogonal IL-2 and IL-2Rβ system drives persistence and activation of CAR T cells and clearance of bulky lymphoma

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A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia

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Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity

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(2020) Wenliang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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CRISPR screen in regulatory T cells reveals modulators of Foxp3

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(2020) Priya Mittal et al.   Nature Reviews Clinical Oncology

A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function

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(2020) Jeff Vierstra et al.   NATURE

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

(2020) Santosha A. Vardhana et al.   NATURE IMMUNOLOGY

A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

(2020) Nazar Mashtalir et al.   CELL

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

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Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion

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Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas

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(2020) Richard C. Centore et al.   TRENDS IN GENETICS

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The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity

(2019) Sanjivan Gautam et al.   NATURE IMMUNOLOGY

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity–independent genomic targeting

(2019) Joshua Pan et al.   NATURE GENETICS

Mammalian ISWI and SWI/SNF selectively mediate binding of distinct transcription factors

(2019) Darko Barisic et al.   NATURE

Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment

(2019) Xufeng Chen et al.   Cancer Discovery

IL-27 promotes the expansion of self-renewing CD8+ T cells in persistent viral infection

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TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

(2019) Francesca Alfei et al.   NATURE

TOX is a critical regulator of tumour-specific T cell differentiation

(2019) Andrew C. Scott et al.   NATURE

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

(2019) William Farnaby et al.   Nature Chemical Biology

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

(2019) Chen Yao et al.   NATURE IMMUNOLOGY

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

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(2019) Ansuman T. Satpathy et al.   NATURE BIOTECHNOLOGY

Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling

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The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

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(2018) Xinyi Guo et al.   NATURE MEDICINE

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(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

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Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis

(2018) Gabriel J. Sandoval et al.   MOLECULAR CELL

Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

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Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

(2018) Lei Zhang et al.   NATURE

A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

(2018) Brittany C. Michel et al.   NATURE CELL BIOLOGY

Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma

(2018) Rishu Agarwal et al.   NATURE MEDICINE

Chromatin Accessibility and Interactions in the Transcriptional Regulation of T Cells

(2018) Peng Li et al.   Frontiers in Immunology

Transcription Factor IRF4 Promotes CD8 + T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

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Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

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Hepatocyte Nuclear Factor-1βControls Mitochondrial Respiration in Renal Tubular Cells

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Chromatin states define tumour-specific T cell dysfunction and reprogramming

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SMARCB1 is required for widespread BAF complex–mediated activation of enhancers and bivalent promoters

(2017) Robert T Nakayama et al.   NATURE GENETICS

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(2017) Alicia N Schep et al.   NATURE METHODS

An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

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NFATc1 controls the cytotoxicity of CD8+ T cells

(2017) Stefan Klein-Hessling et al.   Nature Communications

The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers

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Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers

(2017) Timothy W R Kelso et al.   eLife

The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

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Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

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The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation

(2016) Xiaofeng Wang et al.   NATURE GENETICS

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice

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Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

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The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

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Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Overcoming T cell exhaustion in infection and cancer

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Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

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Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

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The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

(2014) Makoto Kurachi et al.   NATURE IMMUNOLOGY

ARID1B is a specific vulnerability in ARID1A-mutant cancers

(2014) Katherine C Helming et al.   NATURE MEDICINE

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

The use of endogenous T cells for adoptive transfer

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Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma

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Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

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(2013) Jason D Buenrostro et al.   NATURE METHODS

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

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The Basic Principles of Chimeric Antigen Receptor Design

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Chromatin-Remodeling Factor Brg1 Is Required for Schwann Cell Differentiation and Myelination

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CD8+ T Cells: Foot Soldiers of the Immune System

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A human memory T cell subset with stem cell–like properties

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Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy

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Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

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Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

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Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

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