A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia
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Title
A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia
Authors
Keywords
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Journal
Science Translational Medicine
Volume 13, Issue 625, Pages -
Publisher
American Association for the Advancement of Science (AAAS)
Online
2021-12-23
DOI
10.1126/scitranslmed.abg6986
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- (2018) Frederick L Locke et al. LANCET ONCOLOGY
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- (2018) Stephen J. Schuster et al. NEW ENGLAND JOURNAL OF MEDICINE
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- Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia
- (2015) David L. Porter et al. Science Translational Medicine
- Interleukin-2: Biology, Design and Application
- (2015) Natalia Arenas-Ramirez et al. TRENDS IN IMMUNOLOGY
- Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
- (2015) E. Sotillo et al. Cancer Discovery
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- (2015) E. Wang et al. Cancer Immunology Research
- Managing Cytokine Release Syndrome Associated With Novel T Cell-Engaging Therapies
- (2014) Shannon L. Maude et al. CANCER JOURNAL
- The IL-2 cytokine family in cancer immunotherapy
- (2014) Geok Choo Sim et al. CYTOKINE & GROWTH FACTOR REVIEWS
- IL-2: The First Effective Immunotherapy for Human Cancer
- (2014) S. A. Rosenberg JOURNAL OF IMMUNOLOGY
- Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma: Intent-to-Treat Analysis and Efficacy after Failure to Prior Immunotherapies
- (2013) M. J. Besser et al. CLINICAL CANCER RESEARCH
- Determinants of Successful CD8 + T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice
- (2011) Christopher A. Klebanoff et al. CLINICAL CANCER RESEARCH
- IL-7 determines the homeostatic fitness of T cells by distinct mechanisms at different signalling thresholds in vivo
- (2011) Claire Pearson et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells
- (2011) David M. Barrett et al. HUMAN GENE THERAPY
- Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells
- (2010) Matthew E. Pipkin et al. IMMUNITY
- Phosphoinositide (3,4,5)-Triphosphate Binding to Phosphoinositide-Dependent Kinase 1 Regulates a Protein Kinase B/Akt Signaling Threshold That Dictates T-Cell Migration, Not Proliferation
- (2009) C. Waugh et al. MOLECULAR AND CELLULAR BIOLOGY
- Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo
- (2009) Michael C. Milone et al. MOLECULAR THERAPY
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