Hepatoprotective potential of gabapentin in cecal ligation and puncture-induced sepsis; targeting oxidative stress, apoptosis, and NF-kB/MAPK signaling pathways

Azilsartan Modulates HMGB1/NF-κB/p38/ERK1/2/JNK and Apoptosis Pathways during Renal Ischemia Reperfusion Injury

(2023) Rania Alaaeldin et al.   Cells

Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways

(2022) Michael A. Fawzy et al.   MOLECULES

The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters

(2022) Iart Luca Shytaj et al.   mBio

Russelioside A, a Pregnane Glycoside from <i>Caralluma tuberculate</i>, Inhibits Cell-Intrinsic NF-κB Activity and Metastatic Ability of Breast Cancer Cells

(2022) Rahma Tharwat Sabra et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Quercetin potentiates the hepatoprotective effect of sildenafil and/or pentoxifylline against intrahepatic cholestasis: Role of Nrf2/ARE, TLR4/NF-κB, and NLRP3/IL-1β signaling pathways

(2022) Michael A. Fawzy et al.   LIFE SCIENCES

Dual Topoisomerase I/II Inhibition-Induced Apoptosis and Necro-Apoptosis in Cancer Cells by a Novel Ciprofloxacin Derivative via RIPK1/RIPK3/MLKL Activation

(2022) Rania Alaaeldin et al.   MOLECULES

Inhibition of NF-kB/IL-6/JAK2/STAT3 Pathway and Epithelial-Mesenchymal Transition in Breast Cancer Cells by Azilsartan

(2022) Rania Alaaeldin et al.   MOLECULES

Modulation of Apoptosis and Epithelial-Mesenchymal Transition E-cadherin/TGF-β/Snail/TWIST Pathways by a New Ciprofloxacin Chalcone in Breast Cancer Cells

(2021) RANIA ALAAELDIN et al.   ANTICANCER RESEARCH

Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus

(2021) Amira A. Abdellatef et al.   Journal of Natural Medicines

An investigation of the anti-inflammatory effects of gabapentin on acetic acid-induced colitis in rats

(2021) Azadeh Motavallian et al.   MOLECULAR BIOLOGY REPORTS

Identification of Chemo and Radio-Resistant Sub-Population of Stem Cells in Human Cervical Cancer HeLa Cells

(2021) Nabil Mohie Abdel-Hamid et al.   CANCER INVESTIGATION

In vitro inhibition and molecular docking of a new ciprofloxacin‐chalcone against SARS‐CoV‐2 main protease

(2021) Rania Alaaeldin et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)–NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats

(2021) Michael A. Fawzy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway

(2021) Rania Alaaeldin et al.   MOLECULES

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

AT-MSCs Antifibrotic Activity is Improved by Eugenol through Modulation of TGF-β/Smad Signaling Pathway in Rats

(2020) Moustafa Fathy et al.   MOLECULES

Cell Cycle Arrest and Apoptotic Effect of 7-(4-(N-substituted carbamoylmethyl) piperazin-1-yl) Ciprofloxacin-derivative on HCT 116 and A549 Cancer Cells

(2020) RANIA ALAAELDIN et al.   ANTICANCER RESEARCH

Gabapentin attenuates intestinal inflammation: Role of PPAR-gamma receptor

(2020) Tarcisio Vieira de Brito et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Impact of interleukin IL-6 rs-1474347 and IL-10 rs-1800896 genetic polymorphisms on the susceptibility of HCV-infected Egyptian patients to hepatocellular carcinoma

(2020) Reham M. Abd El-Baky et al.   IMMUNOLOGIC RESEARCH

A New Ciprofloxacin-derivative Inhibits Proliferation and Suppresses the Migration Ability of HeLa Cells

(2020) MOUSTAFA FATHY et al.   ANTICANCER RESEARCH

The protective effect of fenofibrate, triptorelin, and their combination against premature ovarian failure in rats

(2020) Walaa Yehia Abdelzaher et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Cardio-protective impact of gabapentin against doxorubicin-induced myocardial toxicity in rats; emphasis on modulation of inflammatory-apoptotic signaling

(2020) Yara A. Samra et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gabapentin Attenuates Oxidative Stress and Apoptosis in the Diabetic Rat Retina

(2019) Mohammad Shamsul Ola et al.   NEUROTOXICITY RESEARCH

Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation

(2019) Moustafa Fathy et al.   MOLECULES

Liver nitrosation and inflammation in septic rats were suppressed by propofol via downregulating TLR4/NF-κB-mediated iNOS and IL-6 gene expressions

(2018) Gong-Jhe Wu et al.   LIFE SCIENCES

Selective Isolation of Nanog-Positive Human Amniotic Mesenchymal Cells and Differentiation into Cardiomyocytes

(2018) Shingo Otaka et al.   Cellular Reprogramming

Modulatory Role of Gabapentin against Ovalbumin-Induced Asthma, Bronchial and Airway Inflammation in Mice

(2018) Haidy Yosri et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Neuroprotective Effects of Gabapentin Against Cerebral Ischemia Reperfusion-Induced Neuronal Autophagic Injury via Regulation of the PI3K/Akt/mTOR Signaling Pathways

(2018) Bing Chun Yan et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Sepsis-induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions

(2018) Gong-Jhe Wu et al.   LIFE SCIENCES

Modulation of inducible nitric oxide synthase pathway by eugenol and telmisartan in carbon tetrachloride-induced liver injury in rats

(2018) Moustafa Fathy et al.   LIFE SCIENCES

SIRT1 activation by butein attenuates sepsis-induced brain injury in mice subjected to cecal ligation and puncture via alleviating inflammatory and oxidative stress

(2018) Yanrong Zhu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Perfluorocarbon reduces cell damage from blast injury by inhibiting signal paths of NF-κB, MAPK and Bcl-2/Bax signaling pathway in A549 cells

(2017) Zhaorui Zhang et al.   PLoS One

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Role of Exogenous Hsp72 on Liver Dysfunction during Sepsis

(2015) Tsen-Ni Tsai et al.   Biomed Research International

The Role of the Liver in Sepsis

(2014) Jun Yan et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Caecal ligation and puncture induced sepsis in the rat results in increased brain water content and perimicrovessel oedema

(2014) Heather F. Brooks et al.   METABOLIC BRAIN DISEASE

Effect of Exogenous Oct4 Overexpression on Cardiomyocyte Differentiation of Human Amniotic Mesenchymal Cells

(2013) Saori Nagura et al.   Cellular Reprogramming

Melatonin Receptors Mediate Improvements of Survival in a Model of Polymicrobial Sepsis

(2013) Tobias Fink et al.   CRITICAL CARE MEDICINE

Immediate splenectomy down-regulates the MAPK–NF-κB signaling pathway in rat brain after severe traumatic brain injury

(2013) Weihua Chu et al.   Journal of Trauma and Acute Care Surgery

The Impact of Gabapentin Administration on Brain GABA and Glutamate Concentrations: A 7T 1H-MRS Study

(2012) Kejia Cai et al.   NEUROPSYCHOPHARMACOLOGY

Gap Junction Dysfunction Reduces Acetaminophen Hepatotoxicity with Impact on Apoptotic Signaling and Connexin 43 Protein Induction in Rat

(2010) Aya Naiki-Ito et al.   TOXICOLOGIC PATHOLOGY

Management of sepsis in patients with liver failure

(2009) Juan M Canabal et al.   Current Opinion in Critical Care

Gabapentin in traumatic nerve injury pain: A randomized, double-blind, placebo-controlled, cross-over, multi-center study

(2008) Torsten E. Gordh et al.   PAIN