Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway

Modulatory and Toxicological Perspectives on the Effects of the Small Molecule Kinetin

(2021) Eman M. Othman et al.   MOLECULES

Modulation of Apoptosis and Epithelial-Mesenchymal Transition E-cadherin/TGF-β/Snail/TWIST Pathways by a New Ciprofloxacin Chalcone in Breast Cancer Cells

(2021) RANIA ALAAELDIN et al.   ANTICANCER RESEARCH

Natural Triterpenoids Isolated from Akebia trifoliata Stem Explants Exert a Hypoglycemic Effect via α‐Glucosidase Inhibition and Glucose Uptake Stimulation in Insulin‐Resistant HepG2 Cells

(2021) Guoyong Bian et al.   CHEMISTRY & BIODIVERSITY

Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus

(2021) Amira A. Abdellatef et al.   Journal of Natural Medicines

In vitro inhibition and molecular docking of a new ciprofloxacin‐chalcone against SARS‐CoV‐2 main protease

(2021) Rania Alaaeldin et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

The aetiology and molecular landscape of insulin resistance

(2021) David E. James et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proapoptotic Protein Smac Mediates Apoptosis in Ovarian Cancer Cells When ‎Treated with the Carpachromene ‎

(2021) Yunjing Song et al.   Archives of Medical Science

Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)–NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats

(2021) Michael A. Fawzy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AT-MSCs Antifibrotic Activity is Improved by Eugenol through Modulation of TGF-β/Smad Signaling Pathway in Rats

(2020) Moustafa Fathy et al.   MOLECULES

Cell Cycle Arrest and Apoptotic Effect of 7-(4-(N-substituted carbamoylmethyl) piperazin-1-yl) Ciprofloxacin-derivative on HCT 116 and A549 Cancer Cells

(2020) RANIA ALAAELDIN et al.   ANTICANCER RESEARCH

Preconditioning of Adipose-Derived Mesenchymal Stem-Like Cells with Eugenol Potentiates Their Migration and Proliferation In Vitro and Therapeutic Abilities in Rat Hepatic Fibrosis

(2020) Moustafa Fathy et al.   MOLECULES

Integrated structural and functional analysis of the protective effects of kinetin against oxidative stress in mammalian cellular systems

(2020) Muhammad Naseem et al.   Scientific Reports

A New Ciprofloxacin-derivative Inhibits Proliferation and Suppresses the Migration Ability of HeLa Cells

(2020) MOUSTAFA FATHY et al.   ANTICANCER RESEARCH

Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway

(2020) Jiawei Li et al.   PeerJ

Insulin-Driven PI3K-AKT Signaling in the Hepatocyte Is Mediated by Redundant PI3Kα and PI3Kβ Activities and Is Promoted by RAS

(2019) Angela Molinaro et al.   Cell Metabolism

Baicalein improves glucose metabolism in insulin resistant HepG2 cells

(2019) Zongchun Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation

(2019) Moustafa Fathy et al.   MOLECULES

Antiplasmodial natural products: an update

(2019) Nasir Tajuddeen et al.   MALARIA JOURNAL

Genetic syndromes of severe insulin resistance

(2018) A Melvin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

In Vitro Antidiabetic Activity and Mechanism of Action of Brachylaena elliptica (Thunb.) DC

(2018) Idowu Jonas Sagbo et al.   Evidence-based Complementary and Alternative Medicine

In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa

(2018) Moustafa FATHY et al.   Turkish Journal Of Medical Sciences

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic Obesity

(2018) Ann Hammarstedt et al.   PHYSIOLOGICAL REVIEWS

Modulation of inducible nitric oxide synthase pathway by eugenol and telmisartan in carbon tetrachloride-induced liver injury in rats

(2018) Moustafa Fathy et al.   LIFE SCIENCES

Suitability of hepatocyte cell lines HepG2, AML12 and THLE-2 for investigation of insulin signalling and hepatokine gene expression

(2018) Stephanie Sefried et al.   Open Biology

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

(2017) Annika S. Axelsson et al.   Science Translational Medicine

Insulin resistance contributes to multidrug resistance in HepG2 cells via activation of the PERK signaling pathway and upregulation of Bcl-2 and P-gp

(2016) XINYUE LIU et al.   ONCOLOGY REPORTS

Phenolic compounds ameliorate the glucose uptake in HepG2 cells' insulin resistance via activating AMPK

(2015) Qun Huang et al.   Journal of Functional Foods

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

In vivo modulation of iNOS pathway in hepatocellular carcinoma by Nigella sativa

(2013) Moustafa Fathy et al.   Environmental Health and Preventive Medicine

Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa

(2010) Li-Wen Chen et al.   CHEMISTRY & BIODIVERSITY

Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation

(2008) Xiaocheng C. Dong et al.   Cell Metabolism

Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: Role of NF-κB, Akt, ROS and MAP kinase pathway

(2008) Anita Goel et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Isolation of tyrosinase inhibitors fromArtocarpus heterophyllusand use of its extract as antibrowning agent

(2008) Zong-Ping Zheng et al.   MOLECULAR NUTRITION & FOOD RESEARCH