Dual Topoisomerase I/II Inhibition-Induced Apoptosis and Necro-Apoptosis in Cancer Cells by a Novel Ciprofloxacin Derivative via RIPK1/RIPK3/MLKL Activation

Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways

(2022) Michael A. Fawzy et al.   MOLECULES

The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters

(2022) Iart Luca Shytaj et al.   mBio

Russelioside A, a Pregnane Glycoside from <i>Caralluma tuberculate</i>, Inhibits Cell-Intrinsic NF-κB Activity and Metastatic Ability of Breast Cancer Cells

(2022) Rahma Tharwat Sabra et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Targeting necroptosis as an alternative strategy in tumor treatment: From drugs to nanoparticles

(2022) Xinlong Zang et al.   JOURNAL OF CONTROLLED RELEASE

Modulation of Apoptosis and Epithelial-Mesenchymal Transition E-cadherin/TGF-β/Snail/TWIST Pathways by a New Ciprofloxacin Chalcone in Breast Cancer Cells

(2021) RANIA ALAAELDIN et al.   ANTICANCER RESEARCH

Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus

(2021) Amira A. Abdellatef et al.   Journal of Natural Medicines

Identification of Chemo and Radio-Resistant Sub-Population of Stem Cells in Human Cervical Cancer HeLa Cells

(2021) Nabil Mohie Abdel-Hamid et al.   CANCER INVESTIGATION

In vitro inhibition and molecular docking of a new ciprofloxacin‐chalcone against SARS‐CoV‐2 main protease

(2021) Rania Alaaeldin et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Odors and cancer: Current status and future directions

(2021) Flora Gouzerh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)–NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats

(2021) Michael A. Fawzy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway

(2021) Rania Alaaeldin et al.   MOLECULES

Cell Cycle Arrest and Apoptotic Effect of 7-(4-(N-substituted carbamoylmethyl) piperazin-1-yl) Ciprofloxacin-derivative on HCT 116 and A549 Cancer Cells

(2020) RANIA ALAAELDIN et al.   ANTICANCER RESEARCH

Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II

(2020) Kai Xiong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Ciprofloxacin-derivative Inhibits Proliferation and Suppresses the Migration Ability of HeLa Cells

(2020) MOUSTAFA FATHY et al.   ANTICANCER RESEARCH

Towards anticancer fluoroquinolones: A review article

(2019) Mohamed A. A. Abdel‐Aal et al.   ARCHIV DER PHARMAZIE

A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade

(2019) Xiaoxia Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation

(2019) Moustafa Fathy et al.   MOLECULES

Anticancer and antimicrobial effects of novel ciprofloxacin fatty acids conjugates

(2019) Alicja Chrzanowska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa

(2018) Moustafa FATHY et al.   Turkish Journal Of Medical Sciences

Ophiopogonin D′, a Natural Product From Radix Ophiopogonis, Induces in Vitro and in Vivo RIPK1-Dependent and Caspase-Independent Apoptotic Death in Androgen-Independent Human Prostate Cancer Cells

(2018) Zongliang Lu et al.   Frontiers in Pharmacology

Recent developments in topoisomerase targeted cancer chemotherapy

(2018) KirkE. Hevener et al.   Acta Pharmaceutica Sinica B

Modulation of inducible nitric oxide synthase pathway by eugenol and telmisartan in carbon tetrachloride-induced liver injury in rats

(2018) Moustafa Fathy et al.   LIFE SCIENCES

Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion

(2017) Wenwen Zhao et al.   Redox Biology

A Quinone-Containing Compound Enhances Camptothecin-Induced Apoptosis of Lung Cancer Through Modulating Endogenous ROS and ERK Signaling

(2016) Han-Lin Chou et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

RIPK3-Mediated Necroptosis and Apoptosis Contributes to Renal Tubular Cell Progressive Loss and Chronic Kidney Disease Progression in Rats

(2016) Yongjun Zhu et al.   PLoS One

Topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines

(2015) Radha Karki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities

(2015) Mehtap Tugrak et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Necroptosis: An emerging type of cell death in liver diseases

(2014) Waqar Khalid Saeed   WORLD JOURNAL OF GASTROENTEROLOGY

Topoisomerase inhibitors as anticancer agents: a patent update

(2013) Daulat B Khadka et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

CD44 and SSEA-4 positive cells in an oral cancer cell line HSC-4 possess cancer stem-like cell characteristics

(2013) Zenko Noto et al.   ORAL ONCOLOGY

In vivo modulation of iNOS pathway in hepatocellular carcinoma by Nigella sativa

(2013) Moustafa Fathy et al.   Environmental Health and Preventive Medicine

Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: Role of NF-κB, Akt, ROS and MAP kinase pathway

(2008) Anita Goel et al.   CHEMICO-BIOLOGICAL INTERACTIONS