Cellular Mechanisms of Tissue Fibrosis. 3. Novel mechanisms of kidney fibrosis

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1

(2013) Shuyu Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

(2012)   AMERICAN JOURNAL OF KIDNEY DISEASES

Hedgehog-Gli Pathway Activation during Kidney Fibrosis

(2012) Steven L. Fabian et al.   AMERICAN JOURNAL OF PATHOLOGY

Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis

(2012) Ching-Fang Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Podocyte Biology and Pathogenesis of Kidney Disease

(2012) Jochen Reiser et al.   Annual Review of Medicine

Host Responses in Tissue Repair and Fibrosis

(2012) Jeremy S. Duffield et al.   Annual Review of Pathology-Mechanisms of Disease

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

Soluble FLT1 Binds Lipid Microdomains in Podocytes to Control Cell Morphology and Glomerular Barrier Function

(2012) Jing Jin et al.   CELL

Targeting NOX enzymes in pulmonary fibrosis

(2012) Louise Hecker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role played by perivascular cells in kidney interstitial injury

(2012) Andres Rojas et al.   CLINICAL NEPHROLOGY

Activation of pericytes

(2012) Cécile Fligny et al.   CURRENT OPINION IN RHEUMATOLOGY

Medullary Thick Ascending Limb Buffer Vasoconstriction of Renal Outer-Medullary Vasa Recta in Salt-Resistant But Not Salt-Sensitive Rats

(2012) Paul M. O’Connor et al.   HYPERTENSION

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo

(2012) Doris Proebstl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pericyte TIMP3 and ADAMTS1 Modulate Vascular Stability after Kidney Injury

(2012) C. Schrimpf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis

(2012) H. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

(2012) Ivica Grgic et al.   KIDNEY INTERNATIONAL

Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice

(2012) David A. Ferenbach et al.   KIDNEY INTERNATIONAL

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

(2012) Konstantin Stark et al.   NATURE IMMUNOLOGY

A new regulator of podocytes

(2012) Susan J. Allison   Nature Reviews Nephrology

Biology of the renal pericyte

(2012) S. W. Smith et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Chronic VEGF Blockade Worsens Glomerular Injury in the Remnant Kidney Model

(2012) Flavia G. Machado et al.   PLoS One

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

(2012) B. N. Chau et al.   Science Translational Medicine

Podocyte Biology for the Bedside

(2011) J. Ashley Jefferson et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Targeting Endothelium-Pericyte Cross Talk by Inhibiting VEGF Receptor Signaling Attenuates Kidney Microvascular Rarefaction and Fibrosis

(2011) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Migration of Fibrocytes in Fibrogenic Liver Injury

(2011) David Scholten et al.   AMERICAN JOURNAL OF PATHOLOGY

Pivotal role of pericytes in kidney fibrosis

(2011) Yujiro Kida et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Mechanisms of fibrosis: the role of the pericyte

(2011) Claudia Schrimpf et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

PDGFRβ Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development

(2011) Lorin E. Olson et al.   DEVELOPMENTAL CELL

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

(2011) Nariaki Asada et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β

(2011) Hideya Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function

(2011) Claire S. Whyte et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide

(2011) Andrej Kovac et al.   Journal of Neuroinflammation

Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease

(2011) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pirfenidone for Diabetic Nephropathy

(2011) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis

(2011) Yi-Ting Chen et al.   KIDNEY INTERNATIONAL

Macrophages are essential contributors to kidney injury in murine cryoglobulinemic membranoproliferative glomerulonephritis

(2011) Shunhua Guo et al.   KIDNEY INTERNATIONAL

CD248+ stromal cells are associated with progressive chronic kidney disease

(2011) Stuart W. Smith et al.   KIDNEY INTERNATIONAL

c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat

(2011) Yingjie Han et al.   LABORATORY INVESTIGATION

Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

(2011) Guillaume Bollée et al.   NATURE MEDICINE

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

(2011) Swati Bhattacharyya et al.   Nature Reviews Rheumatology

The origin of interstitial myofibroblasts in chronic kidney disease

(2011) Ivica Grgic et al.   PEDIATRIC NEPHROLOGY

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubular Overexpression of Transforming Growth Factor-β1 Induces Autophagy and Fibrosis but Not Mesenchymal Transition of Renal Epithelial Cells

(2010) Robert Koesters et al.   AMERICAN JOURNAL OF PATHOLOGY

Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization

(2010) A. N. Stratman et al.   BLOOD

Stromal regulation of vessel stability by MMP14 and TGF 

(2010) N. E. Sounni et al.   Disease Models & Mechanisms

PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis

(2010) J.S. Duffield et al.   DRUG NEWS & PERSPECTIVES

Angiotensin II revisited: new roles in inflammation, immunology and aging

(2010) Ariela Benigni et al.   EMBO Molecular Medicine

Pirfenidone: an anti-fibrotic therapy for progressive kidney disease

(2010) Monique E Cho et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair

(2010) Bing Li et al.   FASEB JOURNAL

Matrix metalloproteinase 14 overexpression reduces corneal scarring

(2010) S D Galiacy et al.   GENE THERAPY

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

(2010) Bernhard Bielesz et al.   JOURNAL OF CLINICAL INVESTIGATION

Toll-Like Receptors and Danger Signaling in Kidney Injury

(2010) H.-J. Anders   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Resolved: EMT Produces Fibroblasts in the Kidney

(2010) M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Origin of new cells in the adult kidney: results from genetic labeling techniques

(2010) Jeremy S. Duffield et al.   KIDNEY INTERNATIONAL

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

Expander: from expression microarrays to networks and functions

(2010) Igor Ulitsky et al.   Nature Protocols

Macrophage Wnt7b is critical for kidney repair and regeneration

(2010) S.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a microRNA signature of renal ischemia reperfusion injury

(2010) J. G. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage Signaling Pathways: A Novel Target in Renal Disease

(2010) Frank Y. Ma et al.   SEMINARS IN NEPHROLOGY

Macrophages and Immunologic Inflammation of the Kidney

(2010) Jeremy S. Duffield   SEMINARS IN NEPHROLOGY

Targeting the Recruitment of Monocytes and Macrophages in Renal Disease

(2010) Volker Vielhauer et al.   SEMINARS IN NEPHROLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation

(2009) A. N. Stratman et al.   BLOOD

EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures

(2009) O. Salvucci et al.   BLOOD

Bone Marrow Ly6Chigh Monocytes Are Selectively Recruited to Injured Kidney and Differentiate into Functionally Distinct Populations

(2009) S. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of TIMP3 Enhances Interstitial Nephritis and Fibrosis

(2009) Z. Kassiri et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

(2009) Benson C Lu et al.   NATURE GENETICS

Serum Amyloid P Inhibits Fibrosis Through Fc R-Dependent Monocyte-Macrophage Regulation in Vivo

(2009) A. P. Castano et al.   Science Translational Medicine

Prevalence of CKD in the United States: A Sensitivity Analysis Using the National Health and Nutrition Examination Survey (NHANES) 1999-2004

(2008) Jon J. Snyder et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Six2 Defines and Regulates a Multipotent Self-Renewing Nephron Progenitor Population throughout Mammalian Kidney Development

(2008) Akio Kobayashi et al.   Cell Stem Cell

Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis

(2008) Michael Zeisberg   Frontiers in Bioscience-Landmark

VEGF Inhibition and Renal Thrombotic Microangiopathy

(2008) Vera Eremina et al.   NEW ENGLAND JOURNAL OF MEDICINE