Activated mesangial cells induce glomerular endothelial cells proliferation in rat anti‐Thy‐1 nephritis through VEGFA/VEGFR2 and Angpt2/Tie2 pathway

Activated mesangial cells acquire the function of antigen presentation

(2021) Yinghua Zhao et al.   CELLULAR IMMUNOLOGY

Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice

(2020) Simone Ragusa et al.   JOURNAL OF CLINICAL INVESTIGATION

Supramolecular Nanofibers Containing Arginine-Glycine-Aspartate (RGD) Peptides Boost Therapeutic Efficacy of Extracellular Vesicles in Kidney Repair

(2020) Chuyue Zhang et al.   ACS Nano

ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma

(2020) Lin Qi et al.   ONCOGENE

Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities

(2020) Young Sun Choi et al.   Journal of Hematology & Oncology

Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

(2019) Jaeryung Kim et al.   Science Advances

Simultaneous Inhibition of Angiopoietin-2 and VEGF-A with Faricimab in Diabetic Macular Edema: BOULEVARD Phase 2 Randomized Trial

(2019) Jayashree Sahni et al.   OPHTHALMOLOGY

Metanephric mesenchyme-derived Foxd1+ mesangial precursor cells alleviate mesangial proliferative glomerulonephritis

(2019) Meiling Jin et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Tie-2/Angiopoietin pathway modulation as a therapeutic strategy for retinal disease

(2019) Rehan M. Hussain et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Urinary Neuropilin-1: A Predictive Biomarker for Renal Outcome in Lupus Nephritis

(2019) Torres-Salido et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock

(2018) Michelle Trieu et al.   ANESTHESIOLOGY

Vasculotide, an angiopoietin-1 mimetic, reduces pulmonary vascular leakage and preserves microcirculatory perfusion during cardiopulmonary bypass in rats

(2018) N.A.M. Dekker et al.   BRITISH JOURNAL OF ANAESTHESIA

The role of transcriptional factor D-site-binding protein in circadian CCL2 gene expression in anti-Thy1 nephritis

(2018) Yang Lu et al.   Cellular & Molecular Immunology

Tie2 protects the vasculature against thrombus formation in systemic inflammation

(2018) Sarah J. Higgins et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiopoietin-2, Renal Deterioration, Major Adverse Cardiovascular Events and All-Cause Mortality in Patients with Diabetic Nephropathy

(2018) Yi-Chun Tsai et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa

(2018) Kabir A. Khan et al.   Nature Reviews Clinical Oncology

Angiopoietin/Tie2 axis regulates the age-at-injury cerebrovascular response to traumatic brain injury

(2018) Thomas R. Brickler et al.   JOURNAL OF NEUROSCIENCE

Improved angiogenic activity of endothelial progenitor cell in diabetic patients treated with insulin plus metformin

(2018) Simin Asadian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

(2018) Seung-Jun Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of Macrophage Polarization by Human Glomerular Mesangial Cells in Response to the Stimuli in Renal Microenvironment

(2018) Wu-Qiong Liao et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Impaired angiopoietin/Tie2 signaling compromises Schlemm’s canal integrity and induces glaucoma

(2017) Jaeryung Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation

(2017) Samir M. Parikh   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mesangial proliferative glomerulonephritis: A glomerular disease or a non-specific morphological change?

(2017) Luis F. Arias et al.   NEPHROLOGY

Targeted delivery of celastrol to mesangial cells is effective against mesangioproliferative glomerulonephritis

(2017) Ling Guo et al.   Nature Communications

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

(2017) Martin Teichert et al.   Nature Communications

Angiopoietin-2-induced blood–brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling

(2016) Stefanie Gurnik et al.   ACTA NEUROPATHOLOGICA

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems

(2016) L. Eklund et al.   CLINICAL SCIENCE

Gene control of tyrosine kinaseTIE2and vascular manifestations of infections

(2016) Chandra C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury

(2016) Eva Rübig et al.   Scientific Reports

Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation

(2015) Alexander Scholz et al.   Annals of the New York Academy of Sciences

Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2

(2015) F. T. Wu et al.   EMBO Molecular Medicine

Podocytes protect glomerular endothelial cells from hypoxic injury via deSUMOylation of HIF-1α signaling

(2015) Lingyu Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Aspectos celulares y moleculares de la nefropatía diabética, rol del VEGF-A

(2015) Katherine Carranza et al.   NEFROLOGIA

Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade

(2014) Nicolò Rigamonti et al.   Cell Reports

Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy

(2013) Y. Kienast et al.   CLINICAL CANCER RESEARCH

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

(2012) Moritz Felcht et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiopoietin-2, endothelial dysfunction and renal involvement in patients with systemic lupus erythematosus

(2012) Hisham S. El-Banawy et al.   JOURNAL OF NEPHROLOGY

Aldosterone mediates glomerular inflammation in experimental mesangial proliferative glomerulonephritis

(2012) Danping Qin et al.   JOURNAL OF NEPHROLOGY

Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax

(2012) C. C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Angiopoietin-2 levels predict mortality in CKD patients

(2011) Sascha David et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Angiopoietin-2 Interferes with Anti-VEGFR2-Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas

(2010) S.-S. Chae et al.   CLINICAL CANCER RESEARCH

Angiotensin II receptor blockade inhibits acute glomerular injuries with the alteration of receptor expression

(2009) Akiko Mii et al.   LABORATORY INVESTIGATION

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Tie2 receptor antagonist angiopoietin 2 facilitates vascular inflammation in systemic lupus erythematosus

(2008) P Kumpers et al.   ANNALS OF THE RHEUMATIC DISEASES