Article
Food Science & Technology
Marco Busnelli, Stefano Manzini, Alice Colombo, Elsa Franchi, Mitja Laaperi, Reijo Laaksonen, Giulia Chiesa
Summary: This study evaluates the effects of different diets on plasma and aorta lipidome in an athero-prone mouse model. Results show that the cholesterol and fatty acid content of the diets are the main factors affecting lipid accumulation in plasma and aorta. Furthermore, specific lipids such as lactosylceramide, glucosyligalactosylceramide, and individual ceramide species are found to accumulate in diseased aortic segments, serving as markers of atherosclerosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Eeva Sliz, Jean Shin, Shahzad Ahmad, Dylan M. Williams, Stefan Frenzel, Friederike Gauss, Sarah E. Harris, Ann-Kristin Henning, Maria Valdes Hernandez, Yi-Han Hu, Beatriz Jimenez, Muralidharan Sargurupremraj, Carole Sudre, Ruiqi Wang, Katharina Wittfeld, Qiong Yang, Joanna M. Wardlaw, Henry Volzke, Meike W. Vernooij, Jonathan M. Schott, Marcus Richards, Petroula Proitsi, Matthias Nauck, Matthew R. Lewis, Lenore Launer, Norbert Hosten, Hans J. Grabe, Mohsen Ghanbari, Ian J. Deary, Simon R. Cox, Nishi Chaturvedi, Josephine Barnes, Jerome Rotter, Stephanie Debette, M. Arfan Ikram, Myriam Fornage, Tomas Paus, Sudha Seshadri, Zdenka Pausova
Summary: This study found associations between white matter hyperintensities (WMH) and circulating metabolomic measures in a general population of middle-aged and older adults. The metabolomic measures include various lipid measurements and non-lipid metabolites. Some of these measurements show significant sex-specific effects and explain a considerable proportion of WMH variance.
Article
Biochemistry & Molecular Biology
Sarah E. Hancock, Eileen Ding, Emma Johansson Beves, Todd Mitchell, Nigel Turner
Summary: Recent advances in single-cell genomics and transcriptomics have greatly improved our understanding of cellular heterogeneity, but single-cell lipidomics methods have lagged behind. However, we have developed a method combining fluorescence-assisted cell sorting and shotgun lipidomics that allows us to detect and quantify a wide range of phosphatidylcholine and sphingomyelin species from single cells. This method can distinguish between different cell lineages and detect subtle differences in the lipidome between cell lines of the same cancer type. It can also be used in conjunction with other single-cell technologies to provide comprehensive multi-omics data on cells with similar phenotypes, advancing our knowledge on cellular heterogeneity.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Chemistry, Analytical
Huanhuan Wang, Lishi Zhang, Xiaoran Zhang, Jiannan Song, Qin Guo, Xude Zhang, Dong Bai
Summary: This study established a non-invasive and accurate prediction model for atherosclerosis based on lipidomics and mathematical methods. The model can predict different pathological stages of atherosclerosis using seven time points, and the CDA method showed the lowest error rate and the best prediction accuracy.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Medicinal
Mengqi Yang, Huachen Jiao, Yan Li, Lei Zhang, Juan Zhang, Xia Zhong, Yitao Xue
Summary: Guanmaitong granule (GMTG), a traditional Chinese medicine, has been found to regulate serum lipid levels, inhibit inflammatory immune response, and reduce plaque burden and remodeling, showing potential anti-atherosclerosis effects.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Multidisciplinary Sciences
Hsiao-Li Chuang, Chien-Chao Chiu, Ching Lo, Cheng-Chih Hsu, Ju-Yun Liu, Shao-Wen Hung, Shih-Chieh Tsai, Hsiang-Hsuan Sung, Chi-Kuang Leo Wang, Yen-Te Huang
Summary: Atherosclerosis is the main cause of cardiac and peripheral vessel infarction in developed countries. Recent studies have shown that gut microbiota and their metabolites play important roles in the development and progression of cardiovascular disease, but the underlying mechanisms are still unclear. This study aimed to investigate the formation of endothelium plaque lesions in germ-free and specific-pathogen-free ApoE-deficient rats fed a normal chow diet at different time points. The results indicate that gut microbiota may attenuate the development of atherosclerosis.
Article
Pharmacology & Pharmacy
Vijayprakash Manickam, Umesh Kumar Dhawan, Damanpreet Singh, Mahesh Gupta, Manikandan Subramanian
Summary: Pomegranate peel extract promotes the resolution of inflammation in atherosclerosis by improving metabolic profile and enhancing macrophage efferocytosis efficiency.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Magdalena Walicka, Cristina Russo, Michael Baxter, Isaac John, Grazia Caci, Riccardo Polosa
Summary: The purpose of this scoping review is to provide a comprehensive overview of the impact of smoking cessation on metabolic parameters in people with diabetes. Although smoking cessation has clear benefits in terms of reducing cardiovascular morbidity and mortality, there is less evidence for its effects on other diabetes-related complications. Studies have shown mixed results in terms of improvements or temporary deterioration in glycemic control after quitting smoking, with limited research on insulin resistance and lipid parameters. More data is needed to assess the importance of this area.
WORLD JOURNAL OF DIABETES
(2022)
Review
Cardiac & Cardiovascular Systems
Andrea Starsichova
Summary: Cardiovascular diseases are the leading cause of death worldwide, with atherosclerosis being the main underlying pathology. The SR-B1-/-ApoE-R61h/h mouse model mimics clinical coronary heart disease and provides a valuable tool for studying vulnerable plaques, testing treatment options, and exploring new technologies in cardiovascular medicine.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Petra Keul, Susann Peters, Karin von Wnuck Lipinski, Nathalie H. Schroeder, Melissa K. Nowak, Dragos A. Duse, Amin Polzin, Sarah Weske, Markus H. Graeler, Bodo Levkau
Summary: Research indicates that elevated endogenous S1P levels can promote the development of atherosclerosis, hinder cholesterol efflux, and cause genuine plaque rupture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Daniel G. Hackam
Summary: Asymptomatic carotid stenosis (ACS) caused by atherosclerosis poses a risk for cerebrovascular events and cognitive impairment. While most patients can be managed without revascularization, those with vulnerable plaque may benefit from it. Intensive medical management, including lifestyle changes and medication, is essential for all ACS patients to reduce the risk of events in and outside the carotid arteries.
Article
Plant Sciences
Sang-Hyun Ihm, Sin-Hee Park, Jung-Ok Lee, Ok-Ran Kim, Eun-Hye Park, Kyoung-Rak Kim, Jong-Hoon Kim, Byung-Hee Hwang, Ho-Joong Youn, Min-Ho Oak, Kiyuk Chang
Summary: The study shows that Lindera obtusiloba extract (LOE) can improve endothelial dysfunction and reduce plaque inflammation and lesions in a mouse model of atherosclerosis. This is achieved by reducing vascular NADPH oxidase-induced ROS generation.
Article
Cardiac & Cardiovascular Systems
Bo Liu, Fangfang Fan, Bo Zheng, Ying Yang, Jia Jia, Pengfei Sun, Yimeng Jiang, Kaiyin Li, Jiahui Liu, Chuyun Chen, Jianping Li, Yan Zhang, Yong Huo
Summary: Increased RC levels are more strongly associated with new-onset carotid plaque than other conventional lipid parameters in the Chinese community-based population. RC should be considered for early atherosclerosis prevention in participants with lower LDL-C levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Han Wu, Ke Feng, Chao Zhang, Hao Zhang, Jing Zhang, Yunqing Hua, Zhengwei Dong, Yaxian Zhu, Shu Yang, Chuanrui Ma
Summary: Atherosclerosis is a chronic disease characterized by lipid dysfunction and inflammation, and metformin has been shown to protect against atherosclerosis by enhancing autophagy. The mechanism involves metformin promoting autophagy through modulating KLF2 expression to inhibit foam cell formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Hematology
Patricia Snarski, Sergiy Sukhanov, Tadashi Yoshida, Yusuke Higashi, Svitlana Danchuk, Bysani Chandrasekar, Di Tian, Vikara Rivera-Lopez, Patrick Delafontaine
Summary: Macrophage-specific overexpression of IGF-1 led to a reduction in plaque macrophages, foam cells, and atherosclerotic burden, as well as an increase in features of stable atherosclerotic plaque. This effect was likely achieved through a decrease in CXCL12-mediated monocyte recruitment and an increase in ABCA1-dependent macrophage lipid efflux.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bjoern Titz, Raffaella M. Gadaleta, Giuseppe Lo Sasso, Ashraf Elamin, Kim Ekroos, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Review
Medicine, General & Internal
Julia Hoeng, Serge Maeder, Patrick Vanscheeuwijck, Manuel C. Peitsch
INTERNAL AND EMERGENCY MEDICINE
(2019)
Review
Pharmacology & Pharmacy
Klearchos K. Papas, Hector De Leon, Thomas M. Suszynski, Robert C. Johnson
ADVANCED DRUG DELIVERY REVIEWS
(2019)
Article
Medicine, Legal
Stephanie Boue, Walter K. Schlage, David Page, Julia Hoeng, Manuel C. Peitsch
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyi Zhao, Filippo Zanetti, Lin Wang, Jie Pan, Shoaib Majeed, Hans Malmstrom, Manuel C. Peitsch, Julia Hoeng, Yanfang Ren
JOURNAL OF DENTISTRY
(2019)
Article
Surgery
Melinda H. MacDonald, Laura Tasse, Daidong Wang, Gary Zhang, Hector De Leon, Richard Kocharian
Summary: The study compared the hemostatic efficacy of a novel ORC-based product, Surgicel-P, to a collagen-based Hemoblast-B. Surgicel-P demonstrated higher and faster hemostatic efficacy compared to Hemoblast-B, making it a more effective option for managing bleeding.
JOURNAL OF INVESTIGATIVE SURGERY
(2021)
Article
Chemistry, Medicinal
Ainhoa Alzualde, Oihane Jaka, Diogo A. R. S. Latino, Omar Alijevic, Inaki Iturria, Jorge Hurtado de Mendoza, Pavel Pospisil, Stefan Frentzel, Manuel C. Peitsch, Julia Hoeng, Kyoko Koshibu
Summary: The study found nicotine to be the most effective anxiolytic alkaloid tested, with other natural alkaloids also potentially regulating anxiety.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Engineering, Biomedical
Melinda H. MacDonald, Gary Zhang, Laura Tasse, Daidong Wang, Hector De Leon, Richard Kocharian
Summary: Topical hemostatic agents like SURGIFLO and HEMOBLAST were compared in experimentally induced bleeding lesions on pig spleens, with SURGIFLO showing superior efficacy with faster hemostasis and fewer product applications required.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Immunology
Hasmik Yepiskoposyan, Manuel C. Peitsch, Marja Talikka
Summary: Any stressor that disrupts cellular homeostasis can trigger an inflammatory response, with inflammasomes playing a crucial role in this process. Causal biological network models can be used to interpret transcriptomic data and understand inflammasome activation.
INTERNATIONAL JOURNAL OF INFLAMMATION
(2022)
Article
Biology
Sonia Ouadi, Nicolas Sierro, Simon Goepfert, Lucien Bovet, Gaetan Glauser, Armelle Vallat, Manuel C. Peitsch, Felix Kessler, Nikolai V. IVanov
Summary: This study compares the newly assembled clove genome with Eucalyptus grandis to investigate genome evolution in the Myrtaceae family and identifies potential genes involved in the biosynthesis of eugenol. The findings provide important genomic resources for clove research and the Myrtaceae family.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Christopher S. Lacko, Qi Chen, Vivienne Mendoza, Vanessa Parikh, Gary Eichenbaum, Meir Bar-Tal, Chad E. Eckert, Hector De Leon, John P. Matonick, Tushar Sharma
Summary: In this study, a physiologically relevant ex vivo swine model of cardiac ablation was developed, displaying minimal variability and high repeatability. Multiple experiments showed that the ablation depth and width of the ex vivo model were similar to the in vivo model, with low variance. Therefore, this ex vivo model can reduce animal usage and increase testing efficiency.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Food Science & Technology
Stephanie Johne, Marco Van der Toorn, Anita R. Iskandar, Shoaib Majeed, Laura O. Torres, Julia Hoeng, Manuel C. Peitsch
Summary: Homemade e-liquids and power-adjustable vaping devices may pose higher risks than commercial formulations and fixed-power devices. This study examined the toxicity of homemade e-liquids containing various chemicals and power settings using human cell cultures. The results showed that certain chemicals in the e-liquids caused cytotoxicity and disrupted epithelial function, while higher power settings generated higher levels of toxic compounds. These findings suggest the need for toxicity assessments for both e-liquid formulations and their aerosols.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Oncology
Hector De Leon, Kevin Royalty, Louie Mingione, David Jaekel, Sarvesh Periyasamy, David Wilson, Paul Laeseke, William C. Stoffregen, Tim Muench, John P. Matonick, Grzegorz L. Kaluza, Gustavo Cipolla
Summary: This study evaluated the safety of bronchoscopic microwave ablation (MWA) using the NEUWAVE FLEX Microwave Ablation System and MONARCH Platform in a swine model. The results showed that there were no major procedural complications and no postprocedural adverse events were observed. This method can be considered for further investigation in patients with oligometastatic disease or primary NSCLC.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Article
Biochemistry & Molecular Biology
Catherine Verhaeghe, Marja Talikka, Alain Sewer, Nicolas Sierro, Mehdi Auberson, Dariusz Peric, David Bornand, Remi Dulize, Emmanuel Guedj, Patrick Nef, Sebastien P. Tabruyn, Julia Hoeng, Manuel C. Peitsch, Giuseppe Lo Sasso
Summary: This study investigated the potential anti-inflammatory activities of tobacco alkaloids nicotine and anatabine in a fully humanized UC mouse model. The results showed that nicotine significantly reduced acute colitis symptoms and improved colitis-specific endpoints. Anatabine also demonstrated similar effectiveness, although weaker or not significant. Gene expression analysis provided insights into the possible mechanism by which nicotine attenuated DSS-induced colitis in humanized mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
David Bovard, Marco van der Toorn, Walter K. Schlage, Samuel Constant, Kasper Renggli, Manuel C. Peitsch, Julia Hoeng
Summary: This study confirms the efficacy and safety of Iota-carrageenan nasal spray in preventing SARS-CoV-2 infection. The nasal spray can inhibit the virus from entering and replicating in cells, and it does not cause toxicity or harm to the respiratory epithelium.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)