Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism inC57BL/6andApoe−/−Mice—An Integrative Systems Toxicology Analysis

Profiling over 1500 Lipids in Induced Lung Sputum and the Implications in Studying Lung Diseases

(2015) Ruben t’Kindt et al.   ANALYTICAL CHEMISTRY

Diseases of Pulmonary Surfactant Homeostasis

(2015) Jeffrey A. Whitsett et al.   Annual Review of Pathology-Mechanisms of Disease

Sphingolipids as cell fate regulators in lung development and disease

(2015) Joyce Lee et al.   APOPTOSIS

Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice

(2015) Mathieu C. Morissette et al.   EUROPEAN RESPIRATORY JOURNAL

A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product

(2015) Blaine Phillips et al.   FOOD AND CHEMICAL TOXICOLOGY

Aerosol from a candidate modified risk tobacco product has reduced effects on chemotaxis and transendothelial migration compared to combustion of conventional cigarettes

(2015) Marco van der Toorn et al.   FOOD AND CHEMICAL TOXICOLOGY

Risk factors and early origins of chronic obstructive pulmonary disease

(2015) Dirkje S Postma et al.   LANCET

Polyunsaturated fatty acid–phospholipid remodeling and inflammation

(2015) Philippe Pierre Robichaud et al.   Current Opinion in Endocrinology Diabetes and Obesity

Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems

(2015) Stéphanie Boué et al.   Database-The Journal of Biological Databases and Curation

Untargeted Lipidomic Analysis in Chronic Obstructive Pulmonary Disease. Uncovering Sphingolipids

(2014) Eef D. Telenga et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models

(2014) Florian Martin et al.   BMC BIOINFORMATICS

Systems Toxicology: From Basic Research to Risk Assessment

(2014) Shana J. Sturla et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Proteomics for systems toxicology

(2014) Bjoern Titz et al.   Computational and Structural Biotechnology Journal

The Cyclooxygenase-2–Prostaglandin E2Pathway Maintains Senescence of Chronic Obstructive Pulmonary Disease Fibroblasts

(2013) Maylis Dagouassat et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation

(2013) Michael Lietz et al.   ATHEROSCLEROSIS

Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods

(2013) Leif Väremo et al.   NUCLEIC ACIDS RESEARCH

Cigarette smoke induces molecular responses in respiratory tissues of ApoE−/− mice that are progressively deactivated upon cessation

(2013) Stéphanie Boué et al.   TOXICOLOGY

COPD and gender differences: an update

(2013) Shambhu Aryal et al.   Translational Research

Modulation of atherogenic lipidome by cigarette smoke in apolipoprotein E-deficient mice

(2012) Stéphanie Boué et al.   ATHEROSCLEROSIS

Regulation of lung surfactant phospholipid synthesis and metabolism

(2012) Victoria Goss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid phosphate phosphatase (LPP3) and vascular development

(2012) H. Ren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks

(2012) Florian Martin et al.   BMC Systems Biology

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

(2012) Anja Wilmes et al.   Journal of Proteomics

Reduced exposure evaluation of an Electrically Heated Cigarette Smoking System. Part 1: Non-clinical and clinical insights

(2012) Matthias K. Schorp et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Atherogenic and pulmonary responses of ApoE- and LDL receptor-deficient mice to sidestream cigarette smoke

(2012) Sung Gu Han et al.   TOXICOLOGY

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of Lipid Homeostasis by the Bifunctional SREBF2-miR33a Locus

(2011) Guido T. Bommer et al.   Cell Metabolism

Lipid Mediator Profiling in Pulmonary Disease

(2011) Susanna L. Lundstrom et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Elevation of surfactant protein A in plasma and sputum in cigarette smokers

(2011) W. Mazur et al.   EUROPEAN RESPIRATORY JOURNAL

Lipidomic changes in rat liver after long-term exposure to ethanol

(2011) Harshica Fernando et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Srebf1a is a key regulator of transcriptional control for adipogenesis

(2011) Jorge-Tonatiuh Ayala-Sumuano et al.   Scientific Reports

Hazardous Compounds in Tobacco Smoke

(2011) Reinskje Talhout et al.   International Journal of Environmental Research and Public Health

Advances in Mass Spectrometry for Lipidomics

(2010) Stephen J. Blanksby et al.   Annual Review of Analytical Chemistry

Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary Disease

(2010) Jeffrey A. Whitsett et al.   Annual Review of Medicine

A systems approach to mapping transcriptional networks controlling surfactant homeostasis

(2010) Yan Xu et al.   BMC GENOMICS

Sphingolipid-mediated Inhibition of Apoptotic Cell Clearance by Alveolar Macrophages

(2010) Daniela N. Petrusca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice

(2010) James P. Bridges et al.   JOURNAL OF CLINICAL INVESTIGATION

Markers of Monocyte Activation Revealed by Lipidomic Profiling of Arachidonic Acid-Containing Phospholipids

(2010) D. Balgoma et al.   JOURNAL OF IMMUNOLOGY

Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD

(2010) Gnanapragasam Arunachalam et al.   Journal of Inflammation-London

Gender differences in COPD: are women more susceptible to smoking effects than men?

(2010) I.-C. Sorheim et al.   THORAX

Eicosanoids and the endogenous control of acute inflammatory resolution

(2009) Derek W. Gilroy   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pharmacological Blockade of the DP2 Receptor Inhibits Cigarette Smoke-Induced Inflammation, Mucus Cell Metaplasia, and Epithelial Hyperplasia in the Mouse Lung

(2009) K. J. Stebbins et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Progression of atherosclerosis in the Apo E−/− model: 12-Month exposure to cigarette mainstream smoke combined with high-cholesterol/fat diet

(2008) K. von Holt et al.   ATHEROSCLEROSIS

COPD-related morbidity and mortality after smoking cessation: status of the evidence

(2008) N. S. Godtfredsen et al.   EUROPEAN RESPIRATORY JOURNAL

Update of the LIPID MAPS comprehensive classification system for lipids

(2008) Eoin Fahy et al.   JOURNAL OF LIPID RESEARCH

EET Displays Anti-Inflammatory Effects in TNF-α–Stimulated Human Bronchi

(2007) Caroline Morin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY