ER‐phagy in neurodegeneration

A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy

(2023) Xinyi Wang et al.   JOURNAL OF CELL BIOLOGY

Anti-Inflammatory Anthranilate Analogue Enhances Autophagy through mTOR and Promotes ER-Turnover through TEX264 during Alzheimer-Associated Neuroinflammation

(2022) Zhiyu Wang et al.   ACS Chemical Neuroscience

Architecture of the endoplasmic reticulum plays a role in proteostasis

(2022) Smriti Parashar et al.   Autophagy

Association between Unc-51-like autophagy activating kinase 2 gene polymorphisms and schizophrenia in the Korean population

(2022) Won Sub Kang et al.   MEDICINE

The different autophagy degradation pathways and neurodegeneration

(2022) Angeleen Fleming et al.   NEURON

ER-phagy: mechanisms, regulation and diseases connected to the lysosomal clearance of the endoplasmic reticulum

(2022) Fulvio Reggiori et al.   PHYSIOLOGICAL REVIEWS

C53 Interacting with UFM1-Protein Ligase 1 Regulates Microtubule Nucleation in Response to ER Stress

(2022) Anastasiya Klebanovych et al.   Cells

RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway

(2022) Rongjin Luo et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Novel RETREG1 ( FAM134B) founder allele is linked to HSAN2B and renal disease in a Turkish family

(2022) Elifcan Taşdelen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The unfolded protein response transducer IRE1α promotes reticulophagy in podocytes

(2022) José R. Navarro-Betancourt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phosphorylation by casein kinase 2 enhances the interaction between ER‐phagy receptor TEX264 and ATG8 proteins

(2022) Haruka Chino et al.   EMBO REPORTS

The Common Cellular Events in the Neurodegenerative Diseases and the Associated Role of Endoplasmic Reticulum Stress

(2022) Soojeong Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy

(2022) Giorgia Di Lorenzo et al.   Science Advances

Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites

(2021) Haoxi Wu et al.   DEVELOPMENTAL CELL

A Potential Autophagy-Related Competing Endogenous RNA Network and Corresponding Diagnostic Efficacy in Schizophrenia

(2021) Rongjie Li et al.   Frontiers in Psychiatry

Late-onset hereditary sensory and autonomic neuropathy type 2B caused by novel compound heterozygous mutations in FAM134B presenting as chronic recurrent ulcers on the soles

(2021) Ze-Yu Luo et al.   Indian Journal of Dermatology Venereology & Leprology

Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy

(2021) Thaddaeus Mutugi Nthiga et al.   JOURNAL OF CELL BIOLOGY

Atlastin 2/3 regulate ER targeting of the ULK1 complex to initiate autophagy

(2021) Nan Liu et al.   JOURNAL OF CELL BIOLOGY

Roles of FAM134B in diseases from the perspectives of organelle membrane morphogenesis and cellular homeostasis

(2021) Luoyi Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Disease-causing mutated ATLASTIN 3 is excluded from distal axons and reduces axonal autophagy

(2021) Laura Behrendt et al.   NEUROBIOLOGY OF DISEASE

The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor

(2021) Thaddaeus Mutugi Nthiga et al.   Autophagy

Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER‐phagy, and Collagen quality control

(2021) Alessio Reggio et al.   EMBO REPORTS

Protein Aggregation in the ER: Calm behind the Storm

(2021) Haisen Li et al.   Cells

Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy

(2020) Jonathan A. Stefely et al.   Autophagy

FAM 134B oligomerization drives endoplasmic reticulum membrane scission for ER ‐phagy

(2020) Xiao Jiang et al.   EMBO JOURNAL

Autophagy in Parkinson's Disease

(2020) Xu Hou et al.   JOURNAL OF MOLECULAR BIOLOGY

Reticulon Homology Domain-Containing Proteins and ER-Phagy

(2020) Manuela D’Eletto et al.   Frontiers in Cell and Developmental Biology

A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation

(2020) Jin Rui Liang et al.   CELL

RETREG1/FAM134B mediated autophagosomal degradation of AMFR/GP78 and OPA1 —a dual organellar turnover mechanism

(2020) Debdatto Mookherjee et al.   Autophagy

CALCOCO 1 acts with VAMP ‐associated proteins to mediate ER ‐phagy

(2020) Thaddaeus Mutugi Nthiga et al.   EMBO JOURNAL

MiT/ TFE factors control ER ‐phagy via transcriptional regulation of FAM 134B

(2020) Laura Cinque et al.   EMBO JOURNAL

Differential expression of full length and N-terminally truncated FAM134B isoforms in normal physiology and cancer

(2020) Umur Keleş et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

(2020) Madlen Stephani et al.   eLife

Fine‐tuning ER‐phagy by post‐translational modifications

(2020) Mohamed A. Eldeeb et al.   BIOESSAYS

Characterization of constitutive ER-phagy of excess membrane proteins

(2020) Zhanna Lipatova et al.   PLoS Genetics

BAP31 deficiency contributes to the formation of amyloid-β plaques in Alzheimer’s disease by reducing the stability of RTN3

(2019) Tianyi Wang et al.   FASEB JOURNAL

ATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy

(2019) Qingzhou Chen et al.   CURRENT BIOLOGY

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

(2019) Heeseon An et al.   MOLECULAR CELL

Intrinsically Disordered Protein TEX264 Mediates ER-phagy

(2019) Haruka Chino et al.   MOLECULAR CELL

Linking the Endoplasmic Reticulum to Parkinson’s Disease and Alpha-Synucleinopathy

(2019) Emanuela Colla   Frontiers in Neuroscience

Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms

(2019) Chantell S. Evans et al.   JOURNAL OF MOLECULAR BIOLOGY

The various shades of ER‐phagy

(2019) Alexandra Stolz et al.   FEBS Journal

De novo pathogenic DNM1L variant in a patient diagnosed with atypical hereditary sensory and autonomic neuropathy

(2019) Maja Tarailo‐Graovac et al.   Molecular Genetics & Genomic Medicine

Excessive ER-phagy mediated by the autophagy receptor FAM134B results in ER stress, the unfolded protein response, and cell death in HeLa cells

(2019) Yangjie Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hereditary sensory autonomic neuropathy type II: Report of two novel mutations in the FAM134B gene

(2019) Catarina Falcão de Campos et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress

(2019) Marisa Loi et al.   Nature Communications

Hereditary Sensory and Autonomic Neuropathy 2B Caused by a Novel RETREG1 Mutation (c.765dupT) and Paternal Uniparental Isodisomy of Chromosome 5

(2019) Geun-Young Park et al.   Frontiers in Genetics

Disposing of misfolded ER proteins: A troubled substrate's way out of the ER

(2019) Christina Oikonomou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hereditary Neuropathies

(2018) Katja Eggermann et al.   Deutsches Arzteblatt International

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis

(2018) Matthew D. Smith et al.   DEVELOPMENTAL CELL

Crosstalk between presynaptic trafficking and autophagy in Parkinson's disease

(2018) Ping-Yue Pan et al.   NEUROBIOLOGY OF DISEASE

Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering

(2018) Michiel Krols et al.   Cell Reports

ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

(2018) Ilaria Fregno et al.   EMBO JOURNAL

Atlastins remodel the endoplasmic reticulum for selective autophagy

(2018) Jin Rui Liang et al.   JOURNAL OF CELL BIOLOGY

A selective ER‐phagy exerts procollagen quality control via a Calnexin‐FAM134B complex

(2018) Alison Forrester et al.   EMBO JOURNAL

Sensory neuropathy-causing mutations in ATL3 affect ER–mitochondria contact sites and impair axonal mitochondrial distribution

(2018) Michiel Krols et al.   HUMAN MOLECULAR GENETICS

Noncanonical autophagy at ER exit sites regulates procollagen turnover

(2018) Shakib Omari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy impairment in Parkinson’s disease

(2017) Cansu Karabiyik et al.   Essays in Biochemistry

Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases

(2017) Michael G. Erkkinen et al.   Cold Spring Harbor Perspectives in Biology

A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability

(2017) Jiang Liu et al.   Nature Communications

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

(2017) Paolo Grumati et al.   eLife

Oxidative stress, prefrontal cortex hypomyelination and cognitive symptoms in schizophrenia

(2017) D A Maas et al.   Translational Psychiatry

Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders

(2016) Yu Cai et al.   Autophagy

Regulation of amyloid precursor protein processing by its KFERQ motif

(2016) Ji-Seon Park et al.   BMB Reports

FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga

(2016) Abhilash I. Chiramel et al.   JOURNAL OF INFECTIOUS DISEASES

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

(2016) Fiorenza Fumagalli et al.   NATURE CELL BIOLOGY

Rotenone Susceptibility Phenotype in Olfactory Derived Patient Cells as a Model of Idiopathic Parkinson’s Disease

(2016) M. Murtaza et al.   PLoS One

Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events

(2015) Brian J. Conti et al.   MOLECULAR CELL

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

A novel missense mutation confirms ATL3 as a gene for hereditary sensory neuropathy type 1

(2014) Dirk Fischer et al.   BRAIN

Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin GTPase 3

(2014) Uwe Kornak et al.   BRAIN

Is the mTOR-signalling cascade disrupted in Schizophrenia?

(2013) Anand Gururajan et al.   JOURNAL OF NEUROCHEMISTRY

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Mutation in FAM134B causing severe hereditary sensory neuropathy: Figure 1

(2010) Sinéad M Murphy et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy

(2009) Ingo Kurth et al.   NATURE GENETICS

Chaperone-mediated autophagy: selectivity pays off

(2009) Ana Maria Cuervo   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY