The TLR/MyD88 signalling cascade in inflammation and gastric cancer: the immune regulatory network of Helicobacter pylori

Masking of typical TLR4 and TLR5 ligands modulates inflammation and resolution by Helicobacter pylori

(2023) Suneesh Kumar Pachathundikandi et al.   TRENDS IN MICROBIOLOGY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

MicroRNA Modulation of Host Immune Response and Inflammation Triggered by Helicobacter pylori

(2021) Maria Oana Săsăran et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heat‐killed Helicobacter pylori upregulates NKG2D ligands expression on gastric adenocarcinoma cells via Toll‐like receptor 4

(2021) Carolina Hernández et al.   HELICOBACTER

CCRL2 promotes antitumor T-cell immunity via amplifying TLR4-mediated immunostimulatory macrophage activation

(2021) Wei Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmacytoid dendritic cells-derived IFN-α is involved in Helicobacter pylori infection-induced differentiation of Schlafen 4–expressing myeloid-derived suppressor cells

(2021) Xiaodan Xiang et al.   INFECTION AND IMMUNITY

Gastritis, Gastric Polyps and Gastric Cancer

(2021) Helge Waldum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Helicobacter pylori Neutrophil-Activating Protein Directly Interacts with and Activates Toll-like Receptor 2 to Induce the Secretion of Interleukin-8 from Neutrophils and ATRA-Induced Differentiated HL-60 Cells

(2021) Shao-Hsuan Wen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The relative and attributable risks of cardia and non-cardia gastric cancer associated with Helicobacter pylori infection in China: a case-cohort study

(2021) Ling Yang et al.   Lancet Public Health

Immunological Aspects of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Gastric Carcinogenesis

(2020) Jacek Baj et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

(2020) Jacek Baj et al.   Cells

Expression and Significance of MyD88 in Patients With Gastric Cardia Cancer in a High-Incidence Area of China

(2020) Jingyao Chen et al.   Frontiers in Oncology

Characterization and strong risk association of TLR2 del -196 to -174 polymorphism and Helicobacter pylori and their influence on mRNA expression in gastric cancer

(2020) Caroline de Matos Lourenço et al.   World Journal of Gastrointestinal Oncology

The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target

(2020) V. Gambardella et al.   CANCER TREATMENT REVIEWS

TLR2, TLR4 and TLR10 Shape the Cytokine and Chemokine Release of H. pylori-Infected Human DCs

(2020) Theresa Neuper et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The NF-κB Signaling Pathway, the Microbiota, and Gastrointestinal Tumorigenesis: Recent Advances

(2020) Chao Peng et al.   Frontiers in Immunology

Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori

(2020) Nicole Tegtmeyer et al.   Cell Reports

Helicobacter pylori-induced TLR9 Activation and Injury are Associated with the Virulence-Associated Adhesin HopQ

(2020) Samuel D R Dooyema et al.   JOURNAL OF INFECTIOUS DISEASES

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

(2019) Xianjie Jiang et al.   Molecular Cancer

T4SS-dependent TLR5 activation by Helicobacter pylori infection

(2019) Suneesh Kumar Pachathundikandi et al.   Nature Communications

Type IV secretion in Gram-negative and Gram-positive bacteria

(2018) Elisabeth Grohmann et al.   MOLECULAR MICROBIOLOGY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells

(2017) Daniel Yee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Tim-3 reduces Helicobacter pylori-associated inflammation through TLR4/NFκB signaling in vitro

(2017) Fucai Wang et al.   Molecular Medicine Reports

Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA

(2017) Nicole Tegtmeyer et al.   MOLECULAR MICROBIOLOGY

High mobility group box 1/toll-like receptor 4/myeloid differentiation factor 88 signaling promotes progression of gastric cancer

(2017) Yanqiu Yue et al.   TUMOR BIOLOGY

Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy

(2016) J. M. Pitt et al.   ANNALS OF ONCOLOGY

Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment

(2016) Y. Maeda et al.   Cancer Prevention Research

Inflammation in gastric cancer: Interplay of the COX-2/prostaglandin E2and Toll-like receptor/MyD88 pathways

(2016) Kanae Echizen et al.   CANCER SCIENCE

Helicobacter pyloriActivates IL-6-STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species

(2016) Juan-Yu Piao et al.   HELICOBACTER

Schlafen 4–expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia

(2016) Lin Ding et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Expression of Interleukin 1β DuringHelicobacter pyloriInfection of Toll-like Receptor 2 (TLR2)– and TLR10-Expressing HEK293 Cell Lines

(2016) Suneesh Kumar Pachathundikandi et al.   JOURNAL OF INFECTIOUS DISEASES

Association of TLR4 and Treg in Helicobacter pylori Colonization and Inflammation in Mice

(2016) Yanfeng Gong et al.   PLoS One

Toll-like Receptor 10 inHelicobacter pyloriInfection

(2015) Hiroyuki Nagashima et al.   JOURNAL OF INFECTIOUS DISEASES

Innate Immunity Components and Cytokines in Gastric Mucosa in Children withHelicobacter pyloriInfection

(2015) Jacek Michalkiewicz et al.   MEDIATORS OF INFLAMMATION

NKG2D Receptor and Its Ligands in Host Defense

(2015) L. L. Lanier   Cancer Immunology Research

Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection

(2015) M. Ravishankar Ram et al.   PLoS One

MicroRNA and signaling pathways in gastric cancer

(2014) Z Zhang et al.   CANCER GENE THERAPY

Protease-activated receptor 1 suppresses Helicobacter pylori gastritis via the inhibition of macrophage cytokine secretion and interferon regulatory factor 5

(2014) Y-T Chionh et al.   Mucosal Immunology

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Novel role of toll-like receptors inHelicobacter pylori- induced gastric malignancy

(2014) Kaname Uno   WORLD JOURNAL OF GASTROENTEROLOGY

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Helicobacter pylori-induced gastric inflammation and gastric cancer

(2013) Fei Wang et al.   CANCER LETTERS

Deficiency of the Myeloid Differentiation Primary Response Molecule MyD88 Leads to an Early and Rapid Development of Helicobacter-Induced Gastric Malignancy

(2013) Anirban Banerjee et al.   INFECTION AND IMMUNITY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

(2013) Nina R. Salama et al.   NATURE REVIEWS MICROBIOLOGY

Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis

(2013) C L Kennedy et al.   ONCOGENE

Let-7b Is Involved in the Inflammation and Immune Responses Associated with Helicobacter pylori Infection by Targeting Toll-Like Receptor 4

(2013) Gui-gen Teng et al.   PLoS One

MyD88 and its divergent toll in carcinogenesis

(2013) Rosalba Salcedo et al.   TRENDS IN IMMUNOLOGY

Helicobacter pylori and mucosa-associated lymphoid tissue: what's new

(2013) S.-H. Kuo et al.   Hematology-American Society of Hematology Education Program

Toll like receptor signaling in “inflammaging”: microRNA as new players

(2013) Fabiola Olivieri et al.   Immunity & Ageing

microRNA Regulation of Inflammatory Responses

(2012) Ryan M. O'Connell et al.   Annual Review of Immunology

Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis

(2012) Koji Otani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation

(2012) Hazel Tye et al.   CANCER CELL

Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA

(2012) Takeru Hayashi et al.   Cell Host & Microbe

Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis

(2012) M. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into Helicobacter pylori oncoprotein CagA interaction with  1 integrin

(2012) B. Kaplan-Turkoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Effects of Myeloid Differentiation Primary Response Gene 88 (MyD88) Activation on Helicobacter Infection In Vivo and Induction of a Th17 Response

(2011) Marygorret Obonyo et al.   HELICOBACTER

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes

(2011) Ying Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of MyD88 as a novel target of miR-155, involved in negative regulation ofHelicobacter pylori-induced inflammation

(2010) Bin Tang et al.   FEBS LETTERS

Toll-Like Receptor 2- and MyD88-Dependent Phosphatidylinositol 3-Kinase and Rac1 Activation Facilitates the Phagocytosis of Listeria monocytogenes by Murine Macrophages

(2010) Y. Shen et al.   INFECTION AND IMMUNITY

Interferon-gamma secretion is induced in IL-12 stimulated human NK cells by recognition of Helicobacter pylori or TLR2 ligands

(2010) Åsa Lindgren et al.   Innate Immunity

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

(2010) Rosalba Salcedo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR-2-Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells

(2010) A. Sayi et al.   JOURNAL OF IMMUNOLOGY

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

(2010) Xiaoxia Z. West et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells

(2010) Y Torosyan et al.   ONCOGENE

Extracellular and Intracellular Pattern Recognition Receptors Cooperate in the Recognition of Helicobacter pylori

(2009) Roland Rad et al.   GASTROENTEROLOGY

Helicobacter pylori Lipopolysaccharides Upregulate Toll-Like Receptor 4 Expression and Proliferation of Gastric Epithelial Cells via the MEK1/2-ERK1/2 Mitogen-Activated Protein Kinase Pathway

(2009) S.-i. Yokota et al.   INFECTION AND IMMUNITY

Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections

(2008) Ken J. Ishii et al.   Cell Host & Microbe

Helicobacter pylori Augments Growth of Gastric Cancers via the Lipopolysaccharide-Toll-like Receptor 4 Pathway whereas Its Lipopolysaccharide Attenuates Antitumor Activities of Human Mononuclear Cells

(2008) K. Chochi et al.   CLINICAL CANCER RESEARCH

Role of Toll-like receptors in gastrointestinal malignancies

(2008) M Fukata et al.   ONCOGENE