Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Oncology
Xiang Zhu, Tingting Su, Shouhua Wang, Huiqing Zhou, Weibin Shi
Summary: With the development of materials science and biomedicine, the application of nanomaterials in the medical field is growing. This article introduces the use of nanomaterials in the diagnosis and treatment of Helicobacter pylori infection and gastric cancer, highlighting the potential of nano-drug delivery systems to improve treatment efficacy and reduce side effects.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Quynh Anh Nguyen, Leonard Schmitt, Raquel Mejias-Luque, Markus Gerhard
Summary: Helicobacter pylori uses its virulence factors, including the adhesin HopQ, to initiate and regulate the host's inflammatory responses during chronic infection in the human stomach. The interaction between HopQ and human CEACAMs allows the translocation of the CagA protein into host cells through the T4SS. The HopQ-CEACAM interaction plays a crucial role in the adhesion of H. pylori to host cells and modulation of cellular processes.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Victor E. Reyes
Summary: Helicobacter pylori infection is a major risk factor for gastric cancer and is associated with chronic inflammation and DNA damage. Understanding the mechanisms of H. pylori-induced carcinogenesis and immune evasion is crucial for preventing gastric cancer and reducing the burden of this disease.
Article
Multidisciplinary Sciences
Bui Hoang Phuc, Vo Phuoc Tuan, Ho Dang Quy Dung, Tran Thanh Binh, Pham Huu Tung, Tran Dinh Tri, Ngo Phuong Minh Thuan, Vu Van Khien, Tran Thi Huyen Trang, Junko Akada, Takeshi Matsumoto, Yoshio Yamaoka
Summary: The acquisition of tfs3/4 ICE was common in H. pylori strains in patients with gastroduodenal disease in Vietnam, and the complete cluster of tfs3 ICE was a reliable marker for the severity of disease in the H. pylori infected population.
SCIENTIFIC REPORTS
(2021)
Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Oncology
Surinder M. Soond, Andrey A. Zamyatnin
Summary: The relationship between pathogens and the increased risk of cancer has attracted significant attention, particularly the contribution of Helicobacter pylori infection to the risk of developing gastric cancer. Research is increasingly focusing on the mechanisms by which the microorganism affects host cells and the importance of the host immune system in disease progression.
Article
Microbiology
Karin Taxauer, Youssef Hamway, Anna Ralser, Alisa Dietl, Karin Mink, Michael Vieth, Bernhard B. Singer, Markus Gerhard, Raquel Mejias-Luque
Summary: The study found that the interaction between HopQ and CEACAM in Helicobacter pylori is a crucial mechanism for activating the non-canonical NF-kappa B pathway in gastric epithelial cells.
Article
Multidisciplinary Sciences
Carmen Aguilar, Mindaugas Pauzuolis, Malvika Pompaiah, Ehsan Vafadarnejad, Panagiota Arampatzi, Mara Fischer, Dominik Narres, Mastura Neyazi, Ozge Kayisoglu, Thomas Sell, Nils Bluethgen, Markus Morkel, Armin Wiegering, Christoph-Thomas Germer, Stefan Kircher, Andreas Rosenwald, Antoine-Emmanuel Saliba, Sina Bartfeld
Summary: In this study, it was found that Helicobacter pylori prefers to attach to differentiated cells in the pit region of gastric units. Organoid models were used to validate this phenomenon, and it was discovered that differentiated pit cells with high levels of GKN1, GKN2 and PSCA were more susceptible to H. pylori attachment and CagA translocation. It was also found that attachment was unrelated to the expression of MUC5AC or PSCA, but relied on bacterial chemotaxis towards host cell-released urea, which was proportional to the size of the host cell.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Ken Namikawa, Norio Tanaka, Yuki Ota, Manabu Takamatsu, Mayuko Kosugi, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Sayuri Amino, Rie Furuya, Osamu Gotoh, Tomoko Kaneyasu, Izuma Nakayama, Yu Imamura, Tetsuo Noda, Junko Fujisaki, Seiichi Mori
Summary: This study compared the genomic differences between HP-exposed and HP-naive diffuse-type gastric cancer (DGC) and found that they develop along different molecular pathways. This finding provides a basis for early detection strategies in high incidence settings.
JOURNAL OF PATHOLOGY
(2022)
Article
Microbiology
Carrie L. Shaffer, James A. D. Good, Santosh Kumar, K. Syam Krishnan, Jennifer A. Gaddy, John T. Loh, Joseph Chappell, Fredrik Almqvist, Timothy L. Cover, Maria Hadjifrangiskou
Meeting Abstract
Gastroenterology & Hepatology
Jennifer M. Noto, Abha Chopra, John Loh, Judith Romero-Gallo, M. Blanca Piazuelo, Mark W. Watson, Shay Leary, Amber Beckett, Timothy Cover, Simon Mallal, Dawn Israel, Richard M. Peek
Article
Gastroenterology & Hepatology
Jennifer M. Noto, Abha Chopra, John T. Loh, Judith Romero-Gallo, M. Blanca Piazuelo, Mark Watson, Shay Leary, Amber C. Beckett, Keith T. Wilson, Timothy L. Cover, Simon Mallal, Dawn A. Israel, Richard M. Peek
Article
Multidisciplinary Sciences
Amber C. Beckett, John T. Loh, Abha Chopra, Shay Leary, Aung Soe Lin, Wyatt J. McDonnell, Beverly R. E. A. Dixon, Jennifer M. Noto, Dawn A. Israel, Richard M. Peek, Simon Mallal, Holly M. Scott Algood, Timothy L. Cover
Article
Immunology
John T. Loh, Aung Soe Lin, Amber C. Beckett, Mark S. McClain, Timothy L. Cover
INFECTION AND IMMUNITY
(2019)
Article
Biochemical Research Methods
Rhonda R. Caston, John T. Loh, Bradley J. Voss, W. Hayes McDonald, Matthew B. Scholz, Mark S. McClain, Timothy L. Cover
JOURNAL OF PROTEOMICS
(2019)
Article
Immunology
Aung Soe Lin, Samuel D. R. Dooyema, Arwen E. Frick-Cheng, M. Lorena Harvey, Giovanni Suarez, John T. Loh, W. Hayes McDonald, Mark S. McClain, Richard M. Peek, Timothy L. Cover
INFECTION AND IMMUNITY
(2020)
Article
Microbiology
Aung Soe Lin, Mark S. McClain, Amber C. Beckett, Rhonda R. Caston, M. Lorena Harvey, Beverly R. E. A. Dixon, Anne M. Campbell, Jennifer H. B. Shuman, Neha Sawhney, Alberto G. Delgado, John T. Loh, M. Blanca Piazuelo, Holly M. Scott Algood, Timothy L. Cover
Article
Immunology
John T. Loh, Miranda Shum, Scott D. R. Jossart, Anne M. Campbell, Neha Sawhney, W. Hayes McDonald, Matthew B. Scholz, Mark S. McClain, Mark H. Forsyth, Timothy L. Cover
Summary: Helicobacter pylori encounters a wide range of pH values in the human stomach, with the ArsRS two-component system playing a significant role in regulating gene expression, especially in response to pH changes. The study identified a pH-responsive ArsRS regulon, including genes related to acid acclimatization, oxidative stress responses, and metal homeostasis. Mutants lacking ArsRS components showed differences in gene expression compared to strains with intact ArsRS, highlighting the importance of ArsRS-mediated gene regulation in H. pylori adaptation to varying pH conditions.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
M. Lorena Harvey, Aung Soe Lin, Lili Sun, Tatsuki Koyama, Jennifer H. B. Shuman, John T. Loh, Holly M. Scott Algood, Matthew B. Scholz, Mark S. McClain, Timothy L. Cover
Summary: This study investigated the differential fitness of Helicobacter pylori outer membrane proteins in vivo and in vitro using a genetic barcoding method. Most outer membrane protein mutants did not show fitness defects exclusively in vivo, while a babA mutant exhibited a strong fitness advantage in vivo.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
John T. Loh, Jennifer H. B. Shuman, Aung Soe Lin, Natalie Favret, M. Blanca Piazuelo, Simon Mallal, Abha Chopra, Mark S. McClain, Timothy L. Cover
Summary: Gastric inflammation was found to increase the activity of Cag T4SS in Helicobacter pylori, resulting in mutations in the katA gene. These mutations led to increased production of catalase, which enhanced the bacterium's resistance to hydrogen peroxide.
INFECTION AND IMMUNITY
(2022)
Article
Immunology
John T. T. Loh, Emily L. L. Struttmann, Natalie Favret, M. Lorena Harvey, Suman B. B. Pakala, Abha Chopra, Mark S. S. McClain, Timothy L. L. Cover
Summary: Both Helicobacter pylori infection and a high-salt diet are risk factors for gastric cancer. We found that the fur-R88H mutation in H. pylori is positively selected under high-salt conditions, both in vivo and in vitro. The fur-R88H mutation enhances H. pylori fitness under high-salt conditions but reduces fitness under routine culture conditions.
INFECTION AND IMMUNITY
(2023)
Article
Microbiology
Madison G. G. Allen, Miranda Y. Y. Bate, Lauren M. M. Tramonte, Emely Y. Y. Avalos, John Loh, Timothy L. L. Cover, Mark H. H. Forsyth
Summary: This study identified a regulon of 40 genes controlled by the CrdRS two-component system (TCS) in Helicobacter pylori. These genes play important roles in the colonization and survival of H. pylori in the human stomach. Furthermore, the study revealed that the expression of these genes is affected by nitric oxide (NO), providing insights into novel therapeutics.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
John T. Loh, Amber C. Beckett, Matthew B. Scholz, Timothy L. Cover
INFECTION AND IMMUNITY
(2018)
