Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA

Structure, biochemistry, and biology of PAK kinases

(2017) Rakesh Kumar et al.   GENE

Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer

(2017) Aurélie Gagnaire et al.   NATURE REVIEWS MICROBIOLOGY

C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility

(2016) Yoshie Senda et al.   CANCER SCIENCE

Pathobiology of Helicobacter pylori–Induced Gastric Cancer

(2016) Manuel Amieva et al.   GASTROENTEROLOGY

Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b

(2016) Hiroko Nishikawa et al.   Scientific Reports

CagA ofHelicobacter pyloriinteracts with and inhibits the serine-threonine kinase PRK2

(2015) Jyoti Prasad Mishra et al.   CELLULAR MICROBIOLOGY

Helicobacter pyloriCagA protein induces factors involved in the epithelial to mesenchymal transition (EMT) in infected gastric epithelial cells in an EPIYA- phosphorylation-dependent manner

(2015) Ioanna S. Sougleri et al.   FEBS Journal

Composition, structure and function of theHelicobacter pylori cagpathogenicity island encoded type IV secretion system

(2015) Steffen Backert et al.   Future Microbiology

Mutual reinforcement of inflammation and carcinogenesis by the Helicobacter pylori CagA oncoprotein

(2015) Nobumi Suzuki et al.   Scientific Reports

A Specific A/T Polymorphism in Western Tyrosine Phosphorylation B-Motifs Regulates Helicobacter pylori CagA Epithelial Cell Interactions

(2015) Xue-Song Zhang et al.   PLoS Pathogens

CD44 Plays a Functional Role in Helicobacter pylori-induced Epithelial Cell Proliferation

(2015) Nina Bertaux-Skeirik et al.   PLoS Pathogens

Gastrokine 1 inhibits the carcinogenic potentials of Helicobacter pylori CagA

(2014) Jung Hwan Yoon et al.   CARCINOGENESIS

Activation of EGFR and ERBB2 by Helicobacter pylori Results in Survival of Gastric Epithelial Cells With DNA Damage

(2014) Rupesh Chaturvedi et al.   GASTROENTEROLOGY

Helicobacter pylori promotes eukaryotic protein translation by activating phosphatidylinositol 3 kinase/mTOR

(2014) Olga Sokolova et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Systematic Analysis of Phosphotyrosine Antibodies Recognizing Single Phosphorylated EPIYA-Motifs in CagA of Western-Type Helicobacter pylori Strains

(2014) Judith Lind et al.   PLoS One

Helicobacter pylori CagA promotes Snail-mediated epithelial–mesenchymal transition by reducing GSK-3 activity

(2014) Da-Gyum Lee et al.   Nature Communications

Analysis of T4SS-induced signaling by H. pylori using quantitative phosphoproteomics

(2014) Frithjof Glowinski et al.   Frontiers in Microbiology

Natural variant of theHelicobacter pyloriCagA oncoprotein that lost the ability to interact with PAR1

(2013) Kana Hashi et al.   CANCER SCIENCE

H. pylori virulence factor CagA increases intestinal cell proliferation by Wnt pathway activation in a transgenic zebrafish model

(2013) J. T. Neal et al.   Disease Models & Mechanisms

Helicobacter pylori Cytotoxin-Associated Gene A Impairs Human Dendritic Cell Maturation and Function through IL-10-Mediated Activation of STAT3

(2013) R. Kaebisch et al.   JOURNAL OF IMMUNOLOGY

Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

(2013) Nina R. Salama et al.   NATURE REVIEWS MICROBIOLOGY

Molecular Mechanisms of SH2- and PTB-Domain-Containing Proteins in Receptor Tyrosine Kinase Signaling

(2013) M. J. Wagner et al.   Cold Spring Harbor Perspectives in Biology

PAR1b takes the stage in the morphogenetic and motogenetic activity ofHelicobacter pyloriCagA oncoprotein

(2013) Yukie Yamahashi et al.   Cell Adhesion & Migration

The Helicobacter pylori Virulence Effector CagA Abrogates Human β-Defensin 3 Expression via Inactivation of EGFR Signaling

(2012) Bianca Bauer et al.   Cell Host & Microbe

Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA

(2012) Takeru Hayashi et al.   Cell Host & Microbe

Bacterial EPIYA effectors - Where do they come from? What are they? Where are they going?

(2012) Takeru Hayashi et al.   CELLULAR MICROBIOLOGY

H. pyloriinduces the expression of Hath1 in gastric epithelial cells via interleukin-8/STAT3 phosphorylation while suppressing Hes1

(2012) Xin Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains

(2012) Doreen Mueller et al.   JOURNAL OF CLINICAL INVESTIGATION

Helicobacter pylori CagA Triggers Expression of the Bactericidal Lectin REG3γ via Gastric STAT3 Activation

(2012) Kai Syin Lee et al.   PLoS One

Structural insights into Helicobacter pylori oncoprotein CagA interaction with  1 integrin

(2012) B. Kaplan-Turkoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila

(2012) Anica M. Wandler et al.   PLoS Pathogens

Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila

(2012) David W. Reid et al.   Frontiers in Cellular and Infection Microbiology

Helicobacter pylori-induced tyrosine phosphorylation of IKKβ contributes to NF-κB activation

(2011) Cornelia Rieke et al.   BIOLOGICAL CHEMISTRY

Serine Phosphorylation of Cortactin Controls Focal Adhesion Kinase Activity and Cell Scattering Induced by Helicobacter pylori

(2011) Nicole Tegtmeyer et al.   Cell Host & Microbe

Spermine Oxidase Mediates the Gastric Cancer Risk Associated With Helicobacter pylori CagA

(2011) Rupesh Chaturvedi et al.   GASTROENTEROLOGY

Potentiation ofHelicobacter pyloriCagA Protein Virulence through Homodimerization

(2011) Lisa Nagase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polarity-regulating Kinase Partitioning-defective 1b (PAR1b) Phosphorylates Guanine Nucleotide Exchange Factor H1 (GEF-H1) to Regulate RhoA-dependent Actin Cytoskeletal Reorganization

(2011) Yukie Yamahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling

(2011) Kenji Kikuchi et al.   MICROBES AND INFECTION

Helicobacter pylori CagA Disrupts Epithelial Patterning by Activating Myosin Light Chain

(2011) Jonathan B. Muyskens et al.   PLoS One

Helicobacter pylori Perturbs Iron Trafficking in the Epithelium to Grow on the Cell Surface

(2011) Shumin Tan et al.   PLoS Pathogens

Regulation of p53 Tumor Suppressor by Helicobacter pylori in Gastric Epithelial Cells

(2010) Jinxiong Wei et al.   GASTROENTEROLOGY

Helicobacter pylori CagL Activates ADAM17 to Induce Repression of the Gastric H, K-ATPase α Subunit

(2010) Arindam Saha et al.   GASTROENTEROLOGY

The Versatility of Helicobacter pylori CagA Effector Protein Functions: The Master Key Hypothesis

(2010) Steffen Backert et al.   HELICOBACTER

Helicobacter pyloriCagA Phosphorylation Status Determines the gp130-activated SHP2/ERK and JAK/STAT Signal Transduction Pathways in Gastric Epithelial Cells

(2010) In Ohk Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Fibronectin-mimicking Protein from Bacteria Induces Cell Spreading and Focal Adhesion Formation

(2010) Nicole Tegtmeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytokine signalling via gp130 in gastric cancer

(2009) M. Howlett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Helicobacter pylori Cytotoxin-Associated Gene A Activates the Signal Transducer and Activator of Transcription 3 Pathway In vitro and In vivo

(2009) D. M. Bronte-Tinkew et al.   CANCER RESEARCH

Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation

(2009) Masato Suzuki et al.   Cell Host & Microbe

Host Cell Interactome of Tyrosine-Phosphorylated Bacterial Proteins

(2009) Matthias Selbach et al.   Cell Host & Microbe

Stability ofHelicobacter pyloriCagA oncoprotein in human gastric epithelial cells

(2009) Susumu Ishikawa et al.   FEBS LETTERS

Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori-Induced Apoptosis

(2009) Fang Yan et al.   GASTROENTEROLOGY

Role of Partitioning-defective 1/Microtubule Affinity-regulating Kinases in the Morphogenetic Activity ofHelicobacter pyloriCagA

(2009) Huaisheng Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CagA Associates with c‐Met, E‐Cadherin, and p120‐Catenin in a Multiproteic Complex That SuppressesHelicobacter pylori–Induced Cell‐Invasive Phenotype

(2009) Maria Jose Oliveira et al.   JOURNAL OF INFECTIOUS DISEASES

Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates

(2009) Dragana Nes̆ić et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

αPix interacts withHelicobacter pyloriCagA to induce IL-8 expression in gastric epithelial cells

(2009) Joo Weon Lim et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Helicobacter pyloriactivates protein kinase C delta to control Raf in MAP kinase signalling: Role in AGS epithelial cell scattering and elongation

(2009) Sabine Brandt et al.   CELL MOTILITY AND THE CYTOSKELETON

Helicobacter pylori Type IV Secretion Apparatus Exploits β1 Integrin in a Novel RGD-Independent Manner

(2009) Luisa F. Jiménez-Soto et al.   PLoS Pathogens

Regulation of Gastric Carcinogenesis by Helicobacter pylori Virulence Factors

(2008) A. T. Franco et al.   CANCER RESEARCH

Analysis of detergent-resistant membranes of Helicobacter pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity

(2008) Zaher Zeaiter et al.   CELLULAR MICROBIOLOGY

OipA plays a role in Helicobacter pylori-induced focal adhesion kinase activation and cytoskeletal re-organization

(2008) Fazal H. Tabassam et al.   CELLULAR MICROBIOLOGY

H. pyloriselectively blocks EGFR endocytosis via the non-receptor kinase c-Abl and CagA

(2008) Bianca Bauer et al.   CELLULAR MICROBIOLOGY

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

(2008) N. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Transgenic Drosophila Model Demonstrates That the Helicobacter pylori CagA Protein Functions as a Eukaryotic Gab Adaptor

(2008) Crystal M. Botham et al.   PLoS Pathogens