CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosis

Marginal zone B cells acquire dendritic cell functions by trogocytosis

(2022) Patrick Schriek et al.   SCIENCE

Differential trafficking of ligands trogocytosed via CD28 versus CTLA4 promotes collective cellular control of co-stimulation

(2022) Simon Zenke et al.   Nature Communications

Antigen-presenting T cells provide critical B7 co-stimulation for thymic iNKT cell development via CD28-dependent trogocytosis

(2022) Masashi Watanabe et al.   Cell Reports

Abatacept as salvage therapy in chronic graft-versus-host disease—a retrospective analysis

(2021) Tobias Wertheimer et al.   ANNALS OF HEMATOLOGY

Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen

(2021) Viola L. Boccasavia et al.   Cell Reports

The Role of Trogocytosis in the Modulation of Immune Cell Functions

(2021) Kensuke Miyake et al.   Cells

Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells

(2021) Murat Tekguc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors

(2021) Xiaozheng Xu et al.   eLife

Trogocytosis in Unicellular Eukaryotes

(2021) Kumiko Nakada-Tsukui et al.   Cells

Quorum Regulation via Nested Antagonistic Feedback Circuits Mediated by the Receptors CD28 and CTLA-4 Confers Robustness to T Cell Population Dynamics

(2020) Simon Zenke et al.   IMMUNITY

PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2

(2020) Xiaozheng Xu et al.   JOURNAL OF CELL BIOLOGY

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

(2020) Dominik Trzupek et al.   Genome Medicine

Regulatory T cells: Master thieves of the immune system

(2020) Billur Akkaya et al.   CELLULAR IMMUNOLOGY

Regulatory T cells mediate specific suppression by depleting peptide–MHC class II from dendritic cells

(2019) Billur Akkaya et al.   NATURE IMMUNOLOGY

Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States

(2019) Spencer C. Wei et al.   IMMUNITY

PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

(2019) Yunlong Zhao et al.   IMMUNITY

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

Does T Cell Activation Require a Quorum of Lymphocytes?

(2018) Ghassan A. Al-Yassin et al.   JOURNAL OF IMMUNOLOGY

Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies

(2017) Mengnan He et al.   Oncotarget

Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease

(2016) John Attanasio et al.   IMMUNITY

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

(2016) Frank A. Schildberg et al.   IMMUNITY

A Transendocytosis Model of CTLA-4 Function Predicts Its Suppressive Behavior on Regulatory T Cells

(2015) Tie Zheng Hou et al.   JOURNAL OF IMMUNOLOGY

Confusing signals: Recent progress in CTLA-4 biology

(2015) Lucy S.K. Walker et al.   TRENDS IN IMMUNOLOGY

The Number of Responding CD4 T Cells and the Dose of Antigen Conjointly Determine the Th1/Th2 Phenotype by Modulating B7/CD28 Interactions

(2014) C. D. Rudulier et al.   JOURNAL OF IMMUNOLOGY

The Activation and Inactivation of Mature CD4 T cells: A Case for Peripheral Self-Nonself Discrimination

(2014) P. A. Bretscher   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

On the Mechanism Determining the Th1/Th2 Phenotype of an Immune Response, and its Pertinence to Strategies for the Prevention, and Treatment, of Certain Infectious Diseases

(2014) P. A. Bretscher   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

(2014) H. S. Kuehn et al.   SCIENCE

Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells

(2013) Audrey Gérard et al.   NATURE IMMUNOLOGY

Quorum sensing allows T cells to discriminate between self and nonself

(2013) T. C. Butler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basis of CTLA-4 function in regulatory and conventional CD4+ T cells

(2012) X. Tai et al.   BLOOD

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin

(2012) B. Zakeri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation

(2011) Kajsa Wing et al.   TRENDS IN IMMUNOLOGY

Antigen-specific T-T interactions regulate CD4 T-cell expansion

(2008) J. Helft et al.   BLOOD

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE

CTLA-4 trafficking and surface expression

(2008) Elke Valk et al.   TRENDS IN IMMUNOLOGY