Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors

Determination of the molecular reach of the protein tyrosine phosphatase SHP-1

(2021) Lara Clemens et al.   BIOPHYSICAL JOURNAL

Molecular mechanism of SHP2 activation by PD-1 stimulation

(2020) M. Marasco et al.   Science Advances

PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2

(2020) Xiaozheng Xu et al.   JOURNAL OF CELL BIOLOGY

SHP-2 and PD-L1 inhibition combined with radiotherapy enhances systemic antitumor effects in an anti-PD-1-resistant model of non-small-cell lung cancer

(2020) Dawei Chen et al.   Cancer Immunology Research

The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis

(2019) Michelle A. Mintz et al.   IMMUNITY

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

(2019) Javier Celis-Gutierrez et al.   Cell Reports

The Influence of Molecular Reach and Diffusivity on the Efficacy of Membrane-Confined Reactions

(2019) Ying Zhang et al.   BIOPHYSICAL JOURNAL

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2

(2018) Ricardo A. P. Pádua et al.   Nature Communications

CD4 + T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness

(2017) Tomasz Ahrends et al.   IMMUNITY

Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor

(2017) Michael Peled et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1

(2017) Jesse Goyette et al.   Science Advances

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging

(2014) Martin Ovesný et al.   BIOINFORMATICS

Surface Passivation for Single-molecule Protein Studies

(2014) Stanley D. Chandradoss et al.   Jove-Journal of Visualized Experiments

Protein-tyrosine phosphatases: a new frontier in platelet signal transduction

(2013) Yotis A. Senis   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

SLAM Family Receptors and SAP Adaptors in Immunity

(2011) Jennifer L. Cannons et al.   Annual Review of Immunology

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Tyrosine phosphatases Shp1 and Shp2 have unique and opposing roles in oligodendrocyte development

(2010) Emory Kuo et al.   JOURNAL OF NEUROCHEMISTRY

Theory of Free Energy and Entropy in Noncovalent Binding

(2009) Huan-Xiang Zhou et al.   CHEMICAL REVIEWS

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

(2009) Ulrike Lorenz   IMMUNOLOGICAL REVIEWS

PD-1 signaling in primary T cells

(2009) James L. Riley   IMMUNOLOGICAL REVIEWS

Statistical Thermodynamics of the Stability of Multivalent Ligand-Receptor Complexes

(2008) D. J. Diestler et al.   PHYSICAL REVIEW LETTERS