Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-𝜅B-IL-6 axis of tumor-associated macrophages

IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment

(2022) Sara G. Manore et al.   Frontiers in Oncology

Spatial Transcriptomics for Tumor Heterogeneity Analysis

(2022) Qiongyu Li et al.   Frontiers in Genetics

The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition

(2022) Peng Liu et al.   Molecular Cancer

The Single‐Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer

(2022) Yutian Zou et al.   Advanced Science

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

MALT1 as a promising target to treat lymphoma and other diseases related to MALT1 anomalies

(2021) Xuewu Liang et al.   MEDICINAL RESEARCH REVIEWS

Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker

(2021) Fernanda G. Kugeratski et al.   NATURE CELL BIOLOGY

Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells

(2021) Ji Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amplification of spatially isolated adenosine pathway by tumor–macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma

(2021) Jia-Cheng Lu et al.   Journal of Hematology & Oncology

circRNAs: Insight Into Their Role in Tumor-Associated Macrophages

(2021) Saili Duan et al.   Frontiers in Oncology

Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles

(2021) Xuefeng Fei et al.   Journal of Extracellular Vesicles

Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal cancer by enhancing M2 polarization of macrophages

(2020) Dong Wang et al.   CANCER LETTERS

The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer

(2020) Xiaying Zheng et al.   Molecular Cancer

IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis

(2020) Rasmus Siersbæk et al.   CANCER CELL

Cancer Cells Don’t Live Alone: Metabolic Communication within Tumor Microenvironments

(2020) Fuming Li et al.   DEVELOPMENTAL CELL

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

(2020) Peng-Fei Zhang et al.   Molecular Cancer

Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression

(2020) Trine Line Hauge Okholm et al.   Genome Medicine

Tumor microenvironment as a therapeutic target in cancer

(2020) Yi Xiao et al.   PHARMACOLOGY & THERAPEUTICS

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis

(2019) Chen Wei et al.   Molecular Cancer

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells

(2019) Fei Chen et al.   NATURE CELL BIOLOGY

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells

(2019) Marc Rosenbaum et al.   Nature Communications

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Protease Nexin I is a feedback regulator of EGF/PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness

(2019) Tingting Tang et al.   Cell Death & Disease

SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4

(2019) Jianglan Zhang et al.   CANCER LETTERS

Change in Populations of Macrophages Promotes Development of Delayed Gastric Emptying in Mice

(2018) Gianluca Cipriani et al.   GASTROENTEROLOGY

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

PLGA-Based Nanoparticles in Cancer Treatment

(2018) Sima Rezvantalab et al.   Frontiers in Pharmacology

JAK2-binding long noncoding RNA promotes breast cancer brain metastasis

(2017) Shouyu Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

A slow-cycling subpopulation of melanoma cells with highly invasive properties

(2017) M Perego et al.   ONCOGENE

Polymers in the Co-delivery of siRNA and Anticancer Drugs for the Treatment of Drug-resistant Cancers

(2017) Haotian Sun et al.   Topics in Current Chemistry

Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?

(2016) Annelies Demeyer et al.   TRENDS IN MOLECULAR MEDICINE

Serpin E2 promotes breast cancer metastasis by remodeling the tumor matrix and polarizing tumor associated macrophages

(2016) Tatiana Smirnova et al.   Oncotarget

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

(2016) Hweixian Leong Penny et al.   OncoImmunology

Global Cancer Incidence and Mortality Rates and Trends--An Update

(2015) L. A. Torre et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The paracaspase MALT1: biological function and potential for therapeutic inhibition

(2015) Maike Jaworski et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis

(2015) Elvin Wagenblast et al.   NATURE

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6′-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-κB Activation

(2014) Xue-Qiang Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breast cancer in China

(2014) Lei Fan et al.   LANCET ONCOLOGY

NF-κB in Cellular Senescence and Cancer Treatment

(2014) Hua Jing et al.   MOLECULES AND CELLS

Tumor-targeting multi-functional nanoparticles for theragnosis: New paradigm for cancer therapy

(2012) Ju Hee Ryu et al.   ADVANCED DRUG DELIVERY REVIEWS

The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis

(2010) Sébastien Bergeron et al.   Molecular Cancer

The Serine Protease Inhibitor Protease Nexin-1 Controls Mammary Cancer Metastasis through LRP-1-Mediated MMP-9 Expression

(2009) B. Fayard et al.   CANCER RESEARCH

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY