Precise and systematic end group chemistry modifications on PAMAM and poly(l-lysine) dendrimers to improve cytosolic delivery of mRNA

Drug delivery systems for RNA therapeutics

(2022) Kalina Paunovska et al.   NATURE REVIEWS GENETICS

A high-throughput Galectin-9 imaging assay for quantifying nanoparticle uptake, endosomal escape and functional RNA delivery

(2021) Michael J. Munson et al.   Communications Biology

Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines

(2021) Thai Thanh Hoang Thi et al.   Vaccines

Synthetic modified messenger RNA for therapeutic applications

(2021) Minsong Gao et al.   Acta Biomaterialia

A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems

(2021) Meredith Packer et al.   Nature Communications

Lipodendriplexes mediated enhanced gene delivery: a cellular to pre-clinical investigation

(2020) Imran Tariq et al.   Scientific Reports

Brain gene delivery using histidine and arginine-modified dendrimers for ischemic stroke therapy

(2020) Youngki Lee et al.   JOURNAL OF CONTROLLED RELEASE

DendriPeps: Expanding Dendrimer Functionality by Hybridizing Poly(amidoamine) (PAMAM) Scaffolds with Peptide Segments

(2019) Ryan J. Smith et al.   MACROMOLECULAR RAPID COMMUNICATIONS

A “top-down” approach to actuate poly(amine- co -ester) terpolymers for potent and safe mRNA delivery

(2018) Yuhang Jiang et al.   BIOMATERIALS

Poly (amidoamine) (PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy

(2018) Jun Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

Molecular Strings Significantly Improved the Gene Transfection Efficiency of Polycations

(2018) Huapan Fang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The great escape: how cationic polyplexes overcome the endosomal barrier

(2018) Tanja Bus et al.   Journal of Materials Chemistry B

Highly Efficient In Vivo Targeting of the Pulmonary Endothelium Using Novel Modifications of Polyethylenimine: An Importance of Charge

(2018) Andrew W. Dunn et al.   Advanced Healthcare Materials

Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals

(2017) Colin J. McKinlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model

(2017) Jasdave S. Chahal et al.   Scientific Reports

Bench-to-bedside translation of dendrimers: Reality or utopia? A concise analysis

(2017) Serge Mignani et al.   ADVANCED DRUG DELIVERY REVIEWS

A Single Methylene Group in Oligoalkylamine-Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery

(2016) Anita Jarzębińska et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cationic Polymer Intercalation into the Lipid Membrane Enables Intact Polyplex DNA Escape from Endosomes for Gene Delivery

(2016) Sriram Vaidyanathan et al.   MOLECULAR PHARMACEUTICS

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose

(2016) Jasdave S. Chahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia

(2016) Joseph F. Nabhan et al.   Scientific Reports

Surface-Engineered Dendrimers in Gene Delivery

(2015) Jiepin Yang et al.   CHEMICAL REVIEWS

Polyamidoamine (PAMAM) dendrimers modified with short oligopeptides for early endosomal escape and enhanced gene delivery

(2015) Le Thi Thuy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

(2015) Yong-Bo Hu et al.   Translational Neurodegeneration

Surface-Engineered Dendrimers with a Diaminododecane Core Achieve Efficient Gene Transfection and Low Cytotoxicity

(2014) Hong Chang et al.   BIOCONJUGATE CHEMISTRY

Arginine-Terminated Generation 4 PAMAM Dendrimer as an Effective Nanovector for Functional siRNA Delivery in Vitro and in Vivo

(2014) Cheng Liu et al.   BIOCONJUGATE CHEMISTRY

Synergistic effect of amino acids modified on dendrimer surface in gene delivery

(2014) Fei Wang et al.   BIOMATERIALS

Endosomal Escape: A Bottleneck in Intracellular Delivery

(2014) Harshad K. Shete et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Modulated Protonation of Side Chain Aminoethylene Repeats in N-Substituted Polyaspartamides Promotes mRNA Transfection

(2014) Hirokuni Uchida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Basic amino acid-conjugated polyamidoamine dendrimers with enhanced gene transfection efficiency

(2014) Jung Hyun Park et al.   MACROMOLECULAR RESEARCH

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

A fluorinated dendrimer achieves excellent gene transfection efficacy at extremely low nitrogen to phosphorus ratios

(2014) Mingming Wang et al.   Nature Communications

A review of the current status of siRNA nanomedicines in the treatment of cancer

(2013) Pauline Resnier et al.   BIOMATERIALS

Poly(amidoamine) dendrimer complexes as a platform for gene delivery

(2013) Dzmitry Shcharbin et al.   Expert Opinion on Drug Delivery

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

Effect of unsaturated alkyl chains on transfection activity of poly(amidoamine) dendron-bearing lipids

(2012) Eiji Yuba et al.   JOURNAL OF CONTROLLED RELEASE

Amino acid-modified bioreducible poly(amidoamine) dendrimers: Synthesis, characterization and In vitro evaluation

(2012) Gwang Sig Yu et al.   MACROMOLECULAR RESEARCH

Efficient in Vitro siRNA Delivery and Intramuscular Gene Silencing Using PEG-Modified PAMAM Dendrimers

(2012) Yin Tang et al.   MOLECULAR PHARMACEUTICS

The effect of pH on PAMAM dendrimer–siRNA complexation — Endosomal considerations as determined by molecular dynamics simulation

(2011) Defang Ouyang et al.   BIOPHYSICAL CHEMISTRY

PEGylated Polyamidoamine Dendrimers with Bis-Aryl Hydrazone Linkages for Enhanced Gene Delivery

(2010) Quan Yuan et al.   BIOMACROMOLECULES

Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells

(2010) José L. Santos et al.   JOURNAL OF CONTROLLED RELEASE

In Vitro and In Vivo gene delivery mediated by Lactosylated Dendrimer/α-Cyclodextrin Conjugates (G2) into Hepatocytes

(2010) Hidetoshi Arima et al.   JOURNAL OF CONTROLLED RELEASE

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Alkyl sulfonyl derivatized PAMAM-G2dendrimers as nonviral gene delivery vectors with improved transfection efficiencies

(2010) Julia Morales-Sanfrutos et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Elimination and exchange of trifluoroacetate counter-ion from cationic peptides: a critical evaluation of different approaches

(2007) Stéphane Roux et al.   JOURNAL OF PEPTIDE SCIENCE