Membrane lipid remodeling modulates γ-secretase processivity

Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation

(2022) Gabriel A. Braun et al.   Chemical Science

Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease

(2022) Lei Liu et al.   Alzheimers & Dementia

Aβ profiles generated by Alzheimer’s disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset

(2022) Dieter Petit et al.   MOLECULAR PSYCHIATRY

The Aβ(1–38) peptide is a negative regulator of the Aβ(1–42) peptide implicated in Alzheimer disease progression

(2021) Maa O. Quartey et al.   Scientific Reports

Update and nomenclature proposal for mammalian lysophospholipid acyltransferases, which create membrane phospholipid diversity

(2021) William J. Valentine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association of CSF Aβ38 Levels With Risk of Alzheimer Disease–Related Decline

(2021) Nicholas Cullen et al.   NEUROLOGY

Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function

(2020) Li Kong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

(2019) Doralicia Casares et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LION/web: a web-based ontology enrichment tool for lipidomic data analysis

(2019) Martijn R Molenaar et al.   GigaScience

Aβ43‐producing PS 1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation

(2019) Johannes Trambauer et al.   EMBO REPORTS

An Emerging Group of Membrane Property Sensors Controls the Physical State of Organellar Membranes to Maintain Their Identity

(2018) Toni Radanović et al.   BIOESSAYS

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visualization of Specific γ-Secretase Complexes using Bimolecular Fluorescence Complementation

(2018) Xavier Meckler et al.   JOURNAL OF ALZHEIMERS DISEASE

Phospholipid Remodeling in Physiology and Disease

(2018) Bo Wang et al.   Annual Review of Physiology

Aβ42/Aβ40 Ratios of Presenilin 1 Mutations Correlate with Clinical Onset of Alzheimer’s Disease

(2018) Ning Tang et al.   JOURNAL OF ALZHEIMERS DISEASE

Short Aβ peptides attenuate Aβ42 toxicity in vivo

(2017) Brenda D. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

APP Function and Lipids: A Bidirectional Link

(2017) Marcus O. W. Grimm et al.   Frontiers in Molecular Neuroscience

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

Homeoviscous Adaptation and the Regulation of Membrane Lipids

(2016) Robert Ernst et al.   JOURNAL OF MOLECULAR BIOLOGY

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

(2016) Dominik Paquet et al.   NATURE

Learning by Failing: Ideas and Concepts to Tackle γ-Secretases in Alzheimer's Disease and Beyond

(2015) Bart De Strooper et al.   Annual Review of Pharmacology and Toxicology

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis

(2015) Hiroshi Tsugawa et al.   NATURE METHODS

From zero to six double bonds: phospholipid unsaturation and organelle function

(2015) Bruno Antonny et al.   TRENDS IN CELL BIOLOGY

Lysophospholipid Acyltransferases Mediate Phosphatidylcholine Diversification to Achieve the Physical Properties Required In Vivo

(2014) Takeshi Harayama et al.   Cell Metabolism

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase

(2012) Oliver Holmes et al.   BIOCHEMISTRY

Generation of Alzheimer Disease-associated Amyloid β42/43Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

(2012) Edith Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel γ-Secretase Enzyme Modulators Directly Target Presenilin Protein

(2011) Amelie Ebke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of APP proteolytic processing in lipid metabolism

(2011) Marcus O. W. Grimm et al.   EXPERIMENTAL BRAIN RESEARCH

Emerging roles for lipids in shaping membrane-protein function

(2009) Rob Phillips et al.   NATURE

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyl-CoA:Lysophospholipid Acyltransferases

(2008) Hideo Shindou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent progress on acyl CoA: lysophospholipid acyltransferase research

(2008) Hideo Shindou et al.   JOURNAL OF LIPID RESEARCH

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY