Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease

A blood-based diagnostic test incorporating plasma Aβ42/40 ratio, ApoE proteotype, and age accurately identifies brain amyloid status: findings from a multi cohort validity analysis

(2021) Tim West et al.   Molecular Neurodegeneration

Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

(2021) Valentina N. Lagomarsino et al.   NEURON

γ-Secretase Activity Is Associated with Braak Senile Plaque Stages

(2020) Nobuto Kakuda et al.   AMERICAN JOURNAL OF PATHOLOGY

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

(2019) Lei Liu et al.   JOURNAL OF CELL BIOLOGY

Recognition of the amyloid precursor protein by human γ-secretase

(2019) Rui Zhou et al.   SCIENCE

High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis

(2019) Suzanne E. Schindler et al.   NEUROLOGY

Performance of Fully Automated Plasma Assays as Screening Tests for Alzheimer Disease–Related β-Amyloid Status

(2019) Sebastian Palmqvist et al.   JAMA Neurology

Aβ43 in human Alzheimer’s disease: effects of active Aβ42 immunization

(2019) Lieke Jäkel et al.   Acta Neuropathologica Communications

Religious Orders Study and Rush Memory and Aging Project

(2018) David A. Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

(2018) Celeste M. Karch et al.   Alzheimers Research & Therapy

Short Aβ peptides attenuate Aβ42 toxicity in vivo

(2017) Brenda D. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ

(2017) Lotta Agholme et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Concordance Between Different Amyloid Immunoassays and Visual Amyloid Positron Emission Tomographic Assessment

(2017) Shorena Janelidze et al.   JAMA Neurology

Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability

(2017) Christina R. Muratore et al.   Stem Cell Reports

Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

(2017) Nobuto Kakuda et al.   Acta Neuropathologica Communications

Cerebrospinal fluid analysis detects cerebral amyloid-β accumulation earlier than positron emission tomography

(2016) Sebastian Palmqvist et al.   BRAIN

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

(2016) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

(2016) David M Bolduc et al.   eLife

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

(2016) Shorena Janelidze et al.   Annals of Clinical and Translational Neurology

Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models

(2016) Jochim Reinert et al.   Acta Neuropathologica Communications

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

(2015) Allen C. Chen et al.   JOURNAL OF CELL BIOLOGY

Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease

(2015) Maria Szaruga et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

The amyloid-β degradation pattern in plasma—A possible tool for clinical trials in Alzheimer's disease

(2014) Josef Pannee et al.   NEUROSCIENCE LETTERS

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43

(2013) Masayasu Okochi et al.   Cell Reports

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease

(2012) Nobuto Kakuda et al.   EMBO Molecular Medicine

Data Resource Profile: The Rochester Epidemiology Project (REP) medical records-linkage system

(2012) J. L. St Sauver et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Age-related modulation of γ-secretase activity in non-human primate brains

(2012) Masaki Nishimura et al.   JOURNAL OF NEUROCHEMISTRY

Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease

(2010) Erik Portelius et al.   Molecular Neurodegeneration

Prevalence of mild cognitive impairment is higher in men: The Mayo Clinic Study of Aging

(2010) R. C. Petersen et al.   NEUROLOGY

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

(2010) Maria Z. Kounnas et al.   NEURON

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Prediction of Alzheimer’s Disease Using a Cerebrospinal Fluid Pattern of C-Terminally Truncated β-Amyloid Peptides

(2008) K. Höglund et al.   Neurodegenerative Diseases

The Mayo Clinic Study of Aging: Design and Sampling, Participation, Baseline Measures and Sample Characteristics

(2008) Rosebud O. Roberts et al.   NEUROEPIDEMIOLOGY