Single-cell RNA sequencing defines disease-specific differences between chronic nodular prurigo and atopic dermatitis

T‐cell receptor sequencing specifies psoriasis as a systemic and atopic dermatitis as a skin‐focused, allergen‐driven disease

(2022) Lennart M. Roesner et al.   ALLERGY

Cutaneous Transcriptomics Identifies Fibroproliferative and Neurovascular Gene Dysregulation in Prurigo Nodularis Compared with Psoriasis and Atopic Dermatitis

(2022) Nishadh Sutaria et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Efficacy of dupilumab in chronic prurigo and chronic idiopathic pruritus: a systematic review of current evidence and analysis of response predictors

(2022) M. Gael et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

The translational revolution of itch

(2022) Brian S. Kim   NEURON

Novel Blood Vascular Endothelial Subtype-Specific Markers in Human Skin Unearthed by Single-Cell Transcriptomic Profiling

(2022) Yuliang He et al.   Cells

Nemolizumab efficacy in prurigo nodularis: onset of action on itch and sleep disturbances

(2022) S. Ständer et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

The Role of the Fibronectin Synergy Site for Skin Wound Healing

(2022) Irene Gimeno-LLuch et al.   Cells

Single‐cell profiles reveal distinctive immune response in atopic dermatitis in contrast to psoriasis

(2022) Bowen Zhang et al.   ALLERGY

RNA sequencing reveals the transcriptome profile of the atopic prurigo nodularis with severe itching

(2022) Yixin Shao et al.   EXPERIMENTAL DERMATOLOGY

Critical Players and Therapeutic Targets in Chronic Itch

(2022) Hua Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptomic, Epigenomic, and Neuroanatomic Signatures Differ in Chronic Prurigo, Atopic Dermatitis, and Brachioradial Pruritus

(2022) Konstantin Agelopoulos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Prurigo Nodularis: A Review of IL-31RA Blockade and Other Potential Treatments

(2022) Anthony Bewley et al.   Dermatology and Therapy

Insulin‐like growth factor binding protein 7 (IGFBP7), a link between heart failure and senescence

(2022) Valentina Bracun et al.   ESC Heart Failure

Itch intensity in prurigo nodularis is closely related with dermal interleukin‐31, oncostatin M, IL‐31 receptor alpha, and oncostatin M receptor beta

(2021) Takashi Hashimoto et al.   EXPERIMENTAL DERMATOLOGY

Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade

(2021) Christine Bangert et al.   Science Immunology

Dupilumab as promising treatment for prurigo nodularis: current evidences

(2021) Ludovica Toffoli et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Neurotrophin-3 Promotes the Neuronal Differentiation of BMSCs and Improves Cognitive Function in a Rat Model of Alzheimer's Disease

(2021) Zhongrui Yan et al.   Frontiers in Cellular Neuroscience

Myofibroblast de-differentiation proceeds via distinct transcriptomic and phenotypic transitions

(2021) Sean M. Fortier et al.   JCI Insight

Intractable Itch in Atopic Dermatitis: Causes and Treatments

(2021) Yoshie Umehara et al.   Biomedicines

Insights into adult atopic dermatitis heterogeneity derived from circulating biomarker profiling in patients with moderate‐to‐severe disease

(2021) Jonathan T. Sims et al.   EXPERIMENTAL DERMATOLOGY

Biomarkers in atopic dermatitis—a review on behalf of the International Eczema Council

(2021) Yael Renert-Yuval et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization

(2021) Micah Belzberg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons

(2021) Matthieu Genestine et al.   eLife

Pruritus as a Distinctive Feature of Type 2 Inflammation

(2021) Simone Garcovich et al.   Vaccines

Therapeutic potential of biologics in prurigo nodularis

(2021) Svenja Müller et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Single-cell analysis reveals innate lymphoid cell lineage infidelity in atopic dermatitis

(2021) Natalia Alkon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin 36 expression in psoriasis variants and other dermatologic diseases with psoriasis‐like histopathologic features

(2021) Terese Monette Aquino et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin

(2021) Tracy Tabib et al.   Nature Communications

Nemolizumab plus topical agents in patients with atopic dermatitis (AD) and moderate‐to‐severe pruritus provide improvement in pruritus and signs of AD for up to 68 weeks: results from two phase III, long‐term studies

(2021) K. Kabashima et al.   BRITISH JOURNAL OF DERMATOLOGY

PDGF as an Important Initiator for Neurite Outgrowth Associated with Fibrovascular Membranes in Proliferative Diabetic Retinopathy

(2021) Evy Lefevere et al.   CURRENT EYE RESEARCH

Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab

(2021) Lam C. Tsoi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cluster Analysis of Circulating Plasma Biomarkers in Prurigo Nodularis Reveals a Distinct Systemic Inflammatory Signature in African Americans

(2021) Nishadh Sutaria et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma

(2021) Katharina Rindler et al.   Molecular Cancer

The Role of Th17-Related Cytokines in Atopic Dermatitis

(2020) Makoto Sugaya   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis

(2020) Helen He et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Chronic prurigo: A retrospective study of 168 cases

(2020) Keiko Inui et al.   JOURNAL OF DERMATOLOGY

Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis

(2020) Sonja Ständer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Profilin 1 delivery tunes cytoskeletal dynamics toward CNS axon regeneration

(2020) Rita Pinto-Costa et al.   JOURNAL OF CLINICAL INVESTIGATION

Prurigo Nodularis: Epidemiology and Clinical Features

(2020) Amy H. Huang et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Prurigo Nodularis: Pathogenesis and Management

(2020) Kyle A. Williams et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

New and emerging treatments for inflammatory itch

(2020) Stephen Erickson et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Practical approaches for diagnosis and management of prurigo nodularis: US expert panel consensus

(2020) Sarina Elmariah et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

(2020) Llorenç Solé-Boldo et al.   Communications Biology

Dupilumab in prurigo nodularis: a systematic review of current evidence and analysis of predictive factors to response

(2020) Husein Husein-ElAhmed et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

Human Dermal Fibroblast Subpopulations Are Conserved across Single-Cell RNA Sequencing Studies

(2020) Alex M. Ascensión et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children

(2020) A. Wollenberg et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Atopic dermatitis endotypes and implications for targeted therapeutics

(2019) Tali Czarnowicki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CTGF/CCN2 from Skeletal Muscle to Nervous System: Impact on Neurodegenerative Diseases

(2019) David Gonzalez et al.   MOLECULAR NEUROBIOLOGY

How to Define Chronic Prurigo?

(2019) Manuel P. Pereira et al.   EXPERIMENTAL DERMATOLOGY

Keratin 6, 16 and 17—Critical Barrier Alarmin Molecules in Skin Wounds and Psoriasis

(2019) Xiaowei Zhang et al.   Cells

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions

(2019) Sara M. Garrett et al.   PLoS One

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

(2019) Carolyn M Walsh et al.   eLife

Chronic Prurigo of Nodular Type: A Review

(2018) C Zeidler et al.   ACTA DERMATO-VENEREOLOGICA

Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial

(2018) Emma Guttman-Yassky et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab

(2018) Patrick M. Brunner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution

(2018) Jeffrey B. Cheng et al.   Cell Reports

Neurotrophic and Neuroregenerative Effects of GH/IGF1

(2017) Vittorio Bianchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology of chronic prurigo

(2017) M.P. Pereira et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Recombinant insulin-like growth factor binding protein-4 inhibits proliferation and promotes differentiation of neural progenitor cells

(2017) Hanxu Niu et al.   NEUROSCIENCE LETTERS

TGF-β1 Signaling and Tissue Fibrosis

(2017) Kevin K. Kim et al.   Cold Spring Harbor Perspectives in Biology

BARHL1 Is Downregulated in Alzheimer’s Disease and May Regulate Cognitive Functions through ESR1 and Multiple Pathways

(2017) Debmalya Barh et al.   Genes

IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration

(2017) Alvaro F. Nieto Guil et al.   Scientific Reports

Adrenomedullin Expression in Alzheimer's Brain

(2016) Ana Patricia Fernandez et al.   Current Alzheimer Research

IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain

(2016) Vanesa Nieto-Estévez et al.   Frontiers in Neuroscience

Diverse functions of perlecan in central nervous system cellsin vitro

(2015) Ryosuke Nakamura et al.   ANIMAL SCIENCE JOURNAL

RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications

(2015) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Low-density Lipoprotein Receptor-related Proteins in a Novel Mechanism of Axon Guidance and Peripheral Nerve Regeneration

(2015) Lila M. Landowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased angiogenesis and VEGF expression correlates with disease severity in prurigo patients

(2015) C. Krull et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

IL-24 Inhibits Lung Cancer Cell Migration and Invasion by Disrupting The SDF-1/CXCR4 Signaling Axis

(2015) Janani Panneerselvam et al.   PLoS One

Itch Mechanisms and Circuits

(2014) Liang Han et al.   Annual Review of Biophysics

Periostin levels correlate with disease severity and chronicity in patients with atopic dermatitis

(2014) K. Kou et al.   BRITISH JOURNAL OF DERMATOLOGY

Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties

(2014) M. Augsten et al.   CANCER RESEARCH

Macrophage migration inhibitory factor (MIF) in the stratum corneum: a marker of the local severity of atopic dermatitis

(2014) Chie Yasuda et al.   EXPERIMENTAL DERMATOLOGY

Human T helper type 1 dichotomy: origin, phenotype and biological activities

(2014) Francesco Annunziato et al.   IMMUNOLOGY

Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis

(2014) Atsuhiko Kato et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Perlecan is required for FGF-2 signaling in the neural stem cell niche

(2014) Aurelien Kerever et al.   Stem Cell Research

Effective Control of Recalcitrant Pruritus by Bevacizumab: A Possible Role for Vascular Endothelial Growth Factor in Chronic Itch?

(2013) K Krause et al.   ACTA DERMATO-VENEREOLOGICA

The multifunctional role of filaggrin in allergic skin disease

(2013) Maeve A. McAleer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

(2013) Tong Liu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Role of IGF-1 pathway in lung fibroblast activation

(2013) Chi F Hung et al.   RESPIRATORY RESEARCH

Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling

(2013) Deepshikha Bhardwaj et al.   Frontiers in Cellular Neuroscience

Interleukin-6, a Major Cytokine in the Central Nervous System

(2012) María Erta et al.   International Journal of Biological Sciences

CD8+ T Cells in the Lesional Skin of Atopic Dermatitis and Psoriasis Patients Are an Important Source of IFN-γ, IL-13, IL-17, and IL-22

(2012) DirkJan Hijnen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Nociceptive Signaling Role for Neuromedin B

(2012) S. K. Mishra et al.   JOURNAL OF NEUROSCIENCE

Prurigo as a symptom of atopic and non-atopic diseases: aetiological survey in a consecutive cohort of 108 patients

(2012) A. Iking et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Nuclear localization of activated STAT6 and STAT3 in epidermis of prurigo nodularis

(2011) S. Fukushi et al.   BRITISH JOURNAL OF DERMATOLOGY

Reduced intraepidermal nerve fibre density in lesional and nonlesional prurigo nodularis skin as a potential sign of subclinical cutaneous neuropathy

(2011) B. Schuhknecht et al.   BRITISH JOURNAL OF DERMATOLOGY

CCN1/CYR61: the very model of a modern matricellular protein

(2011) Lester F. Lau   CELLULAR AND MOLECULAR LIFE SCIENCES

Early growth response transcription factors: Key mediators of fibrosis and novel targets for anti-fibrotic therapy

(2011) Swati Bhattacharyya et al.   MATRIX BIOLOGY

Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets

(2011) Joon-Il Jun et al.   NATURE REVIEWS DRUG DISCOVERY

Insulin-Like Growth Factor-1 Regulates Neurite Outgrowth and Neuronal Migration From Organotypic Cultured Dorsal Root Ganglion

(2010) Yujuan Xiang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum

(2010) M. Müller et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The multiple pathways for itch and their interactions with pain

(2010) Steve Davidson et al.   TRENDS IN NEUROSCIENCES

Phthalimide neovascular factor 1 (PNF1) modulates MT1-MMP activity in human microvascular endothelial cells

(2009) Kristen A. Wieghaus et al.   BIOTECHNOLOGY AND BIOENGINEERING

IL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells

(2009) Kristine E. Nograles et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients

(2009) Nils Weigelt et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Insulin-like growth factor binding protein-7 induces activation and transdifferentiation of hepatic stellate cells in vitro

(2009) Li-Xin Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Antigen expression of human eccrine sweat glands

(2008) Hai-Hong Li et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Activation of Proteinase-Activated Receptors Induces Itch-Associated Response Through Histamine-Dependent and -Independent Pathways in Mice

(2008) Kenichiro Tsujii et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Plasminogen activator inhibitor-1: The double-edged sword in apoptosis

(2008) Rashna D. Balsara et al.   THROMBOSIS AND HAEMOSTASIS

Immunological decision-making: how does the immune system decide to mount a helper T-cell response?

(2007) Gerard E. Kaiko et al.   IMMUNOLOGY